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Hassannia, Haddi, Abediankenari, Saeid, Ghaffari, Javad. (1390). FOXP3 and TGF-β Gene Polymorphisms in Allergic Rhinitis. سامانه مدیریت نشریات علمی, 8(4), 218-225.
Haddi Hassannia; Saeid Abediankenari; Javad Ghaffari. "FOXP3 and TGF-β Gene Polymorphisms in Allergic Rhinitis". سامانه مدیریت نشریات علمی, 8, 4, 1390, 218-225.
Hassannia, Haddi, Abediankenari, Saeid, Ghaffari, Javad. (1390). 'FOXP3 and TGF-β Gene Polymorphisms in Allergic Rhinitis', سامانه مدیریت نشریات علمی, 8(4), pp. 218-225.
Hassannia, Haddi, Abediankenari, Saeid, Ghaffari, Javad. FOXP3 and TGF-β Gene Polymorphisms in Allergic Rhinitis. سامانه مدیریت نشریات علمی, 1390; 8(4): 218-225.

FOXP3 and TGF-β Gene Polymorphisms in Allergic Rhinitis

Iranian Journal of Immunology
مقاله 4، دوره 8، شماره 4، اسفند 2011، صفحه 218-225    اصل مقاله (231.8 K)
نوع مقاله: Original Article
نویسندگان
Haddi Hassannia1؛ Saeid Abediankenari* 1؛ Javad Ghaffari2
1Department of Immunology and Microbiology
2Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran
چکیده
Background: Regulatory CD4+T (Treg) cells are effective in maintaining immune tolerance.
Objective: To investigate single nucleotide polymorphisms (SNPs) of Transforming Growth Factor β-1 (TGF-β1) and Forkhead Box Protein 3 (FOXP3) genes in Iranian patients with allergic rhinitis (AR).
Methods: Variations at codons 10 and 25 of TGF-β1 and FOXP3 at positions -3279 A>C and -924 A>G were evaluated in AR patients and compared with controls. In a case-control study, 155 AR patients and 163 allergy- free controls were genotyped using polymerase chain reaction sequence-specific primer (PCR-SSP) technique.
Results: The analysis of the frequency of these SNPs showed that the haplotype formed by FOXP3 -3279 A allele occurred significantly more frequently in patients than controls (odds ratio=1.44, 95% CI=1.312-2.66; p=0.001).
Conclusion: Our results suggest that polymorphism in FOXP3 gene is associated with susceptibility to AR.
کلیدواژه‌ها
Allergic Rhinitis؛ FOXP3؛ gene polymorphisms؛ TGF-β
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