LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,230
تعداد مقالات11,205
تعداد مشاهده مقاله77,964,974
تعداد دریافت فایل اصل مقاله103,384,861
Ghayumi, Mohammad Ali, Mojtahedi, Zahra, Fattahi, Mohammad Javad. (1390). Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion. سامانه مدیریت نشریات علمی, 8(4), 195-200. doi: 10.22034/iji.2011.17026
Mohammad Ali Ghayumi; Zahra Mojtahedi; Mohammad Javad Fattahi. "Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion". سامانه مدیریت نشریات علمی, 8, 4, 1390, 195-200. doi: 10.22034/iji.2011.17026
Ghayumi, Mohammad Ali, Mojtahedi, Zahra, Fattahi, Mohammad Javad. (1390). 'Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion', سامانه مدیریت نشریات علمی, 8(4), pp. 195-200. doi: 10.22034/iji.2011.17026
Ghayumi, Mohammad Ali, Mojtahedi, Zahra, Fattahi, Mohammad Javad. Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion. سامانه مدیریت نشریات علمی, 1390; 8(4): 195-200. doi: 10.22034/iji.2011.17026

Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion

Iranian Journal of Immunology
مقاله 1، دوره 8، شماره 4، اسفند 2011، صفحه 195-200    اصل مقاله (189.97 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2011.17026
نویسندگان
Mohammad Ali Ghayumi1، 2؛ Zahra Mojtahedi* 1؛ Mohammad Javad Fattahi1
1Institute for Cancer Research
2Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: The alteration of Th1 and Th2 cytokine levels is the subject of controversy in pleural effusions caused by malignancy, a situation that favors a Th2 immune response.
Objective: To examine the different levels of IL-4 and IL-10 (Th2 cytokines), and IL-2 and interferon-γ (IFN-γ) (Th1 cytokines) in malignant and non-malignant pleural effusions.
Method: The cytokine levels in pleural fluid of 62 patients with malignant pleural effusion (44 with lung cancer and 18 with extrathoracic tumors), 8 with tuberculous and 8 with congestive heart failure pleural effusion were analysed using enzymelinked immunosorbent assays.
Results: IL-2 was below the detectable concentration of the assay. A significant decrease in IFN-γ level was observed in malignant but not in congestive heart failure cases compared to tuberculous cases. IL-10 levels were higher in malignant and tuberculous pleural effusions than in congestive heart failure pleural effusions, however, this difference did not reach the significant level. IL-4 levels were also increased non-significantly in lung cancer pleural effusions compared to the other groups.
Conclusion: Our results show a wide variation in IL-4, IL-10, and IFN-γ levels in malignant pleural effusions, a pattern which was not convincing enough to differentiate the cause of effusion.
کلیدواژه‌ها
IFN-γ؛ IL-4؛ Lung Cancer؛ Pleural Effusion
آمار
تعداد مشاهده مقاله: 1,464
تعداد دریافت فایل اصل مقاله: 1,092


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب