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Ghayumi, Mohammad Ali, Mojtahedi, Zahra, Fattahi, Mohammad Javad. (1390). Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion. سامانه مدیریت نشریات علمی, 8(4), 195-200.
Mohammad Ali Ghayumi; Zahra Mojtahedi; Mohammad Javad Fattahi. "Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion". سامانه مدیریت نشریات علمی, 8, 4, 1390, 195-200.
Ghayumi, Mohammad Ali, Mojtahedi, Zahra, Fattahi, Mohammad Javad. (1390). 'Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion', سامانه مدیریت نشریات علمی, 8(4), pp. 195-200.
Ghayumi, Mohammad Ali, Mojtahedi, Zahra, Fattahi, Mohammad Javad. Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion. سامانه مدیریت نشریات علمی, 1390; 8(4): 195-200.

Th1 and Th2 Cytokine Profiles in Malignant Pleural Effusion

Iranian Journal of Immunology
مقاله 1، دوره 8، شماره 4، اسفند 2011، صفحه 195-200    اصل مقاله (189.97 K)
نوع مقاله: Original Article
نویسندگان
Mohammad Ali Ghayumi1، 2؛ Zahra Mojtahedi* 1؛ Mohammad Javad Fattahi1
1Institute for Cancer Research
2Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: The alteration of Th1 and Th2 cytokine levels is the subject of controversy in pleural effusions caused by malignancy, a situation that favors a Th2 immune response.
Objective: To examine the different levels of IL-4 and IL-10 (Th2 cytokines), and IL-2 and interferon-γ (IFN-γ) (Th1 cytokines) in malignant and non-malignant pleural effusions.
Method: The cytokine levels in pleural fluid of 62 patients with malignant pleural effusion (44 with lung cancer and 18 with extrathoracic tumors), 8 with tuberculous and 8 with congestive heart failure pleural effusion were analysed using enzymelinked immunosorbent assays.
Results: IL-2 was below the detectable concentration of the assay. A significant decrease in IFN-γ level was observed in malignant but not in congestive heart failure cases compared to tuberculous cases. IL-10 levels were higher in malignant and tuberculous pleural effusions than in congestive heart failure pleural effusions, however, this difference did not reach the significant level. IL-4 levels were also increased non-significantly in lung cancer pleural effusions compared to the other groups.
Conclusion: Our results show a wide variation in IL-4, IL-10, and IFN-γ levels in malignant pleural effusions, a pattern which was not convincing enough to differentiate the cause of effusion.
کلیدواژه‌ها
IFN-γ؛ IL-4؛ Lung Cancer؛ Pleural Effusion
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