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Mohammadi, Mojgan, Hayatbakhsh, Mohammad Mahdi, Zahedi, Mohammad Javad, Jalalpour, Mohammad Reza, Pakgohar, Amin. (1390). Serum Interleukin-23 Levels in Patients with Ulcerative Colitis. سامانه مدیریت نشریات علمی, 8(3), 183-188.
Mojgan Mohammadi; Mohammad Mahdi Hayatbakhsh; Mohammad Javad Zahedi; Mohammad Reza Jalalpour; Amin Pakgohar. "Serum Interleukin-23 Levels in Patients with Ulcerative Colitis". سامانه مدیریت نشریات علمی, 8, 3, 1390, 183-188.
Mohammadi, Mojgan, Hayatbakhsh, Mohammad Mahdi, Zahedi, Mohammad Javad, Jalalpour, Mohammad Reza, Pakgohar, Amin. (1390). 'Serum Interleukin-23 Levels in Patients with Ulcerative Colitis', سامانه مدیریت نشریات علمی, 8(3), pp. 183-188.
Mohammadi, Mojgan, Hayatbakhsh, Mohammad Mahdi, Zahedi, Mohammad Javad, Jalalpour, Mohammad Reza, Pakgohar, Amin. Serum Interleukin-23 Levels in Patients with Ulcerative Colitis. سامانه مدیریت نشریات علمی, 1390; 8(3): 183-188.

Serum Interleukin-23 Levels in Patients with Ulcerative Colitis

Iranian Journal of Immunology
مقاله 6، دوره 8، شماره 3، آذر 2011، صفحه 183-188    اصل مقاله (64.46 K)
نوع مقاله: Original Article
نویسندگان
Mojgan Mohammadi* 1؛ Mohammad Mahdi Hayatbakhsh2؛ Mohammad Javad Zahedi2؛ Mohammad Reza Jalalpour2؛ Amin Pakgohar3
1Physiology Research Centre
2Gastroentrology Department, Afzalipour Hospital, Kerman University of Medical Sciences
3Kerman Blood Transfusion Centre, Kerman, Iran
چکیده
Background: Patients with ulcerative colitis are at increased risk of inflammation. Interleukin 23 (IL-23) is a newly identified cytokine with increased expression in inflamed biopsies of colon mucosa in patients with Crohn's disease; however, there is inconsistent evidence on its role in ulcerative colitis.
Objective: We aimed to compare serum IL-23 level in patients with ulcerative colitis and normal controls and determine if serum IL-23 level increases with the severity of disease according to endoscopic findings.
Methods: We quantified serum IL-23 levels from 60 patients with ulcerative colitis and 20 control individuals. All patients underwent endoscopic procedure to define the severity of disease. Patients were then stratified into 2 groups of "Mild" and "Severe" according to the endoscopic findings.
Results: For comparison of serum IL-23 levels, Platelet count, ESR and CRP between the groups, Mann-Whitney U test and independent sample t test were employed, as appropriate. Pearson’s and spearman's correlation tests were employed to test the association of IL-23 with platelet count, CRP and ESR in patients. Our findings showed that serum IL-23 levels were increased in patients with ulcerative colitis compared to normal control. Moreover, patients in "Severe" group had higher serum IL-23 levels and ESR compared with those in "Mild" group. There was no significant sexual dimorphism in any of studied variables.
Conclusion: We suggest that IL-23 plays an important role in the p
کلیدواژه‌ها
Inflammation؛ Interleukin-23؛ Ulcerative colitis
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