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Shahriari, Shahriar, Rezaei, Aliasghar, Jalazadeh, Seyed Mohsen, Mani, Khosro, Zamani, Alireza. (1390). Effect of Ibuprofen on IL-1β, TNF-α and PGE2 Levels in Periapical Exudates: A Double Blinded Clinical Trial. سامانه مدیریت نشریات علمی, 8(3), 176-182.
Shahriar Shahriari; Aliasghar Rezaei; Seyed Mohsen Jalazadeh; Khosro Mani; Alireza Zamani. "Effect of Ibuprofen on IL-1β, TNF-α and PGE2 Levels in Periapical Exudates: A Double Blinded Clinical Trial". سامانه مدیریت نشریات علمی, 8, 3, 1390, 176-182.
Shahriari, Shahriar, Rezaei, Aliasghar, Jalazadeh, Seyed Mohsen, Mani, Khosro, Zamani, Alireza. (1390). 'Effect of Ibuprofen on IL-1β, TNF-α and PGE2 Levels in Periapical Exudates: A Double Blinded Clinical Trial', سامانه مدیریت نشریات علمی, 8(3), pp. 176-182.
Shahriari, Shahriar, Rezaei, Aliasghar, Jalazadeh, Seyed Mohsen, Mani, Khosro, Zamani, Alireza. Effect of Ibuprofen on IL-1β, TNF-α and PGE2 Levels in Periapical Exudates: A Double Blinded Clinical Trial. سامانه مدیریت نشریات علمی, 1390; 8(3): 176-182.

Effect of Ibuprofen on IL-1β, TNF-α and PGE2 Levels in Periapical Exudates: A Double Blinded Clinical Trial

Iranian Journal of Immunology
مقاله 5، دوره 8، شماره 3، آذر 2011، صفحه 176-182    اصل مقاله (279.47 K)
نوع مقاله: Original Article
نویسندگان
Shahriar Shahriari1؛ Aliasghar Rezaei1؛ Seyed Mohsen Jalazadeh1؛ Khosro Mani2؛ Alireza Zamani* 3، 4
1Department of Endodontics, School of Dentistry
2Department of Community Medicine
3Department of Immunology-Hematology, School of Medicine
4Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
چکیده
Background: Bone resorption is one of the main features of inflammatory periapical lesions and is mainly mediated by interleukin-1 beta (IL-1β), tumor necrosis factoralpha (TNF-α) and prostaglandin-E2 (PGE2). Recent investigations of these lesions revealed that pharmacological modulation may be possible.
Objective: The aim of this study was to evaluate the effect of Ibuprofen on IL-1β, TNF-α and PGE2 levels in periapical exudates and compare the results with a group of placebo control.
Methods: Thirty patients with non vital teeth and radiographic lesions were divided into two groups of case and control according to their entrance to the study. Periapical exudates were taken from root canals using absorbent paper points and followed by 400 mg Ibuprofen and placebo prescribed one tablet every 6 hour for three days and in the fourth day second samples were taken, then final cleaning, shaping and obturation of the canals were completed. IL-1β, TNF-α and PGE2 levels were determined by enzymelinked immunosorbent assays (ELISA). Data were analyzed using paired t-test and student's t-test.
Results: The results showed that PGE2 levels were decreased significantly in the case group to 86.92 ± 72.42 Pg/ml following Ibuprofen treatment comparing with the pre-treatment (164.96 ± 12.255 Pg/ml) (p=0.02) and placebo group (154.2 ± 97.13 Pg/ml) (p=0.001). But there were no significant differences in IL-1β and TNF-α level between the two groups and in each group before and after treatment.
Conclusion: The data indicate that Ibuprofen, as a non-steroidal anti-inflammatory drug (NSAID), can be used to block PGE2 release, enhance healing of inflammatory periapical lesions and possibly to inhibit bone resorption.
کلیدواژه‌ها
ibuprofen؛ Interleukin-1β؛ Lesion؛ Periapical؛ Prostaglandin-E2؛ Tumor necrosis Factor-α
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