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Amirghofran, Zahra, Malek-Hosseini, Saeed, Golmoghaddam, Hossein, Kalantar, Fathollah, Shabani, Mehdi. (1390). Inhibition of Nitric Oxide Production and Proinflammatory Cytokines by Several Medicinal Plants. سامانه مدیریت نشریات علمی, 8(3), 159-169.
Zahra Amirghofran; Saeed Malek-Hosseini; Hossein Golmoghaddam; Fathollah Kalantar; Mehdi Shabani. "Inhibition of Nitric Oxide Production and Proinflammatory Cytokines by Several Medicinal Plants". سامانه مدیریت نشریات علمی, 8, 3, 1390, 159-169.
Amirghofran, Zahra, Malek-Hosseini, Saeed, Golmoghaddam, Hossein, Kalantar, Fathollah, Shabani, Mehdi. (1390). 'Inhibition of Nitric Oxide Production and Proinflammatory Cytokines by Several Medicinal Plants', سامانه مدیریت نشریات علمی, 8(3), pp. 159-169.
Amirghofran, Zahra, Malek-Hosseini, Saeed, Golmoghaddam, Hossein, Kalantar, Fathollah, Shabani, Mehdi. Inhibition of Nitric Oxide Production and Proinflammatory Cytokines by Several Medicinal Plants. سامانه مدیریت نشریات علمی, 1390; 8(3): 159-169.

Inhibition of Nitric Oxide Production and Proinflammatory Cytokines by Several Medicinal Plants

Iranian Journal of Immunology
مقاله 3، دوره 8، شماره 3، آذر 2011، صفحه 159-169    اصل مقاله (395.72 K)
نوع مقاله: Original Article
نویسندگان
Zahra Amirghofran* 1، 2؛ Saeed Malek-Hosseini1؛ Hossein Golmoghaddam1؛ Fathollah Kalantar1؛ Mehdi Shabani1
1Department of Immunology
2Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: A number of medicinal plants have been used to treat various immunological diseases. Nitric oxide (NO) has an important regulatory role in the various types of inflammatory processes.
Objective: To investigate the NO modulatory activity of the extracts of several medicinal plants native to Iran including Dracocephalum kotschyi, Linum persicum, Dionysia termeana, Salvia mirzayanii, Ferulago angulata and Euphorbia cheiradenia.
Methods: The methanolic extracts of the plants were prepared and examined for their effects on the NO production by lipopolysaccharide-stimulated mouse macrophages. The level of TNF-α and IL-1β proinflammatory cytokines in the macrophage culture were detected using enzyme-linked immunosorbent assay.
Results: All the extracts at concentration of 50 μg/ml demonstrated a significant decrease in NO production (p<0.001) after a 24-hour treatment. This inhibitory effect was also seen after 48 hours. Among the extracts, L. persicum was the strongest extract in reducing the NO production at 1 μg/ml after both 24 and 48-hours (nearly 100% inhibition, p<0.001). S. mirzayanii extract with 66.2 ± 8% inhibition at 50 μg/ml, showed the mildest effects in 48 hour culture. In cytokine release determination, the extract of L. persicum significantly inhibited both TNF-α and IL-1β cytokines production by stimulated macrophages (p<0.001). D. kotschyi, D. termeana and F. angulata decreased secretion of IL-1β from the cells.
Conclusion: These results indicate the presence of anti-inflammatory and macrophage inhibitory substances in these plants.
کلیدواژه‌ها
Cytokines؛ medicinal plants؛ Nitric oxide
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