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Ghoraishian, Seyed Mahmood, Hekmati Moghaddam, Seyed Hossein, Afkhami-Ardekani, Mohammad. (1385). Relationship between Anti-Thyroid Peroxidase Antibody and Thyroid Function Test. سامانه مدیریت نشریات علمی, 3(3), 146-149.
Seyed Mahmood Ghoraishian; Seyed Hossein Hekmati Moghaddam; Mohammad Afkhami-Ardekani. "Relationship between Anti-Thyroid Peroxidase Antibody and Thyroid Function Test". سامانه مدیریت نشریات علمی, 3, 3, 1385, 146-149.
Ghoraishian, Seyed Mahmood, Hekmati Moghaddam, Seyed Hossein, Afkhami-Ardekani, Mohammad. (1385). 'Relationship between Anti-Thyroid Peroxidase Antibody and Thyroid Function Test', سامانه مدیریت نشریات علمی, 3(3), pp. 146-149.
Ghoraishian, Seyed Mahmood, Hekmati Moghaddam, Seyed Hossein, Afkhami-Ardekani, Mohammad. Relationship between Anti-Thyroid Peroxidase Antibody and Thyroid Function Test. سامانه مدیریت نشریات علمی, 1385; 3(3): 146-149.

Relationship between Anti-Thyroid Peroxidase Antibody and Thyroid Function Test

Iranian Journal of Immunology
مقاله 8، دوره 3، شماره 3 - شماره پیاپی 10، آذر 2006، صفحه 146-149    اصل مقاله (52.86 K)
نوع مقاله: Original Article
نویسندگان
Seyed Mahmood Ghoraishian* 1؛ Seyed Hossein Hekmati Moghaddam2؛ Mohammad Afkhami-Ardekani3
1Department of Immunology, Medical School
2Department of Laboratory Sciences, Paramedical School
3Department of Endocrinology, Medical School, Yazd University of Medical Sciences, Yazd, Iran
چکیده
Background: Anti-thyroid peroxidase antibody (anti-TPO antibody) is a member of thyroid autoantibodies which are important in inducing and also diagnosing autoimmune thyroid diseases. Thyroid autoimmunity can cause several forms of thyroiditis and abnormal thyroid functions, ranging from hypothyroidism to hyperthyroidism.
Objective: To evaluate the relationship between serum levels of anti-TPO antibody and thyroid function test parameters (T3, T4, and TSH) in patients with thyroid disease.
Methods: In 2425 subjects suspected of having thyroid disease referred to Yazd central medical laboratory by physicians during a 2 year period, the concentrations of serum anti-TPO antibody (ELISA) and T3, T4, and TSH (RIA) were measured.
Results: 53.53% of the patients were 20 to 39 years old. 2135 patients (88.04%) were female and 290 (11.96%) were male. The levels of T3, T4, and TSH in individuals with normal and raised anti-TPO antibody titers was significantly different (P<0.0001). A correlation between TSH and T4 levels and abnormal anti-TPO antibody was detected (P=0.002).
Conclusion: Our results confirm the correlation between thyroid function test and anti-TPO antibody values, indicating the clinical significance of this antibody and suggesting a through clinical examination and follow up of individuals with high anti-TPO antibody titer.
کلیدواژه‌ها
Autoimmune؛ Anti-TPO؛ Thyroid Disease
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