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Nikokar, Iraj, Makvandi, Manouchehr, Kajbaf, Mohammad Javad, Farajzadeh, Ahmad, Mirsaeidi, Mehdi, Kamali-Sarvestani, Eskandar, Mostafaie, Ali, Huygen, Kris. (1385). Evaluation of Cellular Immune Response against Purified Antigen 85 in Patients with Tuberculosis. سامانه مدیریت نشریات علمی, 3(2), 70-77.
Iraj Nikokar; Manouchehr Makvandi; Mohammad Javad Kajbaf; Ahmad Farajzadeh; Mehdi Mirsaeidi; Eskandar Kamali-Sarvestani; Ali Mostafaie; Kris Huygen. "Evaluation of Cellular Immune Response against Purified Antigen 85 in Patients with Tuberculosis". سامانه مدیریت نشریات علمی, 3, 2, 1385, 70-77.
Nikokar, Iraj, Makvandi, Manouchehr, Kajbaf, Mohammad Javad, Farajzadeh, Ahmad, Mirsaeidi, Mehdi, Kamali-Sarvestani, Eskandar, Mostafaie, Ali, Huygen, Kris. (1385). 'Evaluation of Cellular Immune Response against Purified Antigen 85 in Patients with Tuberculosis', سامانه مدیریت نشریات علمی, 3(2), pp. 70-77.
Nikokar, Iraj, Makvandi, Manouchehr, Kajbaf, Mohammad Javad, Farajzadeh, Ahmad, Mirsaeidi, Mehdi, Kamali-Sarvestani, Eskandar, Mostafaie, Ali, Huygen, Kris. Evaluation of Cellular Immune Response against Purified Antigen 85 in Patients with Tuberculosis. سامانه مدیریت نشریات علمی, 1385; 3(2): 70-77.

Evaluation of Cellular Immune Response against Purified Antigen 85 in Patients with Tuberculosis

Iranian Journal of Immunology
مقاله 4، دوره 3، شماره 2 - شماره پیاپی 9، شهریور 2006، صفحه 70-77    اصل مقاله (118.39 K)
نوع مقاله: Original Article
نویسندگان
Iraj Nikokar* 1؛ Manouchehr Makvandi2؛ Mohammad Javad Kajbaf2؛ Ahmad Farajzadeh2؛ Mehdi Mirsaeidi3؛ Eskandar Kamali-Sarvestani4، 5؛ Ali Mostafaie6؛ Kris Huygen7
1Microbiology and Immunology of Infectious Disease Laboratory, Guilan University of Medical Sciences
2Department of Microbiology, Ahwaz University of Medical Sciences
3Department of Tuberculosis, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences
4Department of Immunology and
5Autoimmune Diseases Research Center, Shiraz University of Medical Sciences,
6Department of Microbiology, Kermanshah University of Medical Sciences
7Pasteur Institute of Brussels, Belgium
چکیده
Background: Tuberculosis (TB) remains an important health problem throughout the world. Despite its significance in public health, mechanisms of protective immunity against Mycobacyerium Tuberculosis in humans have not yet been understood.
Objective: To evaluate cell mediated immune response against purified Ag 85, PPD and Phytohemagglutinin (PHA) in patients with tuberculosis and healthy tuberculin positive and negative individuals.
Methods: Thirty patients with tuberculosis and 60 healthy tuberculin skin test positive and negative volunteers were participated in this study. Cell mediated immunity was assessed by measuring [³H]-thymidine uptake and detection of IFN-γ in the culture supernatant using commercial ELISA test.
Results: In the present study, we showed that IFN- γ production and cell proliferation response to Ag 85 were significantly higher in tuberculin positive than tuberculin negative individuals (P<0.01). Among tuberculous patients, IFN-γ production and cell proliferative responses to Ag 85 was significantly lower in contrast to healthy tuberculin positive individuals (P<0.01). In addition, IFN- γ response in patients with cavitary tuberculosis was lower than patients without cavitation (P<0.05).
Conclusion: Based on the higher cell mediated immune responses to Ag 85 in healthy tuberculin positive volunteers compared to patients (especially with advanced disease), purified Ag 85 can be used as a sensitive marker for analysis of immune responses in tuberculosis.
کلیدواژه‌ها
Tuberculosis؛ IFN- γ؛ Cell Proliferation؛ Ag 85
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