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Nikzamir, Abdol Rahim, Golmohammadi, Taghi, Nakhjavani, Manouchehr, Zahraei, Mahine, Amirzargar, Ali Akbar. (1384). Angiotensin Converting Enzyme Gene Polymorphism in Iranian Patients with Type 2 Diabetes. سامانه مدیریت نشریات علمی, 3(1), 23-29.
Abdol Rahim Nikzamir; Taghi Golmohammadi; Manouchehr Nakhjavani; Mahine Zahraei; Ali Akbar Amirzargar. "Angiotensin Converting Enzyme Gene Polymorphism in Iranian Patients with Type 2 Diabetes". سامانه مدیریت نشریات علمی, 3, 1, 1384, 23-29.
Nikzamir, Abdol Rahim, Golmohammadi, Taghi, Nakhjavani, Manouchehr, Zahraei, Mahine, Amirzargar, Ali Akbar. (1384). 'Angiotensin Converting Enzyme Gene Polymorphism in Iranian Patients with Type 2 Diabetes', سامانه مدیریت نشریات علمی, 3(1), pp. 23-29.
Nikzamir, Abdol Rahim, Golmohammadi, Taghi, Nakhjavani, Manouchehr, Zahraei, Mahine, Amirzargar, Ali Akbar. Angiotensin Converting Enzyme Gene Polymorphism in Iranian Patients with Type 2 Diabetes. سامانه مدیریت نشریات علمی, 1384; 3(1): 23-29.

Angiotensin Converting Enzyme Gene Polymorphism in Iranian Patients with Type 2 Diabetes

Iranian Journal of Immunology
مقاله 4، دوره 3، شماره 1 - شماره پیاپی 8، خرداد 2006، صفحه 23-29    اصل مقاله (107.6 K)
نوع مقاله: Original Article
نویسندگان
Abdol Rahim Nikzamir1؛ Taghi Golmohammadi1؛ Manouchehr Nakhjavani2؛ Mahine Zahraei1؛ Ali Akbar Amirzargar* 3
1Department of Medical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2Department of Endocrinology and Metabolism, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3Immunogenetic Laboratory, Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Angiotensin I converting enzyme (ACE) is a Zinc metalloproteinase, converts Ang-I to Ang- II, a pro-inflammatory agent which may contribute to pathophysiology of some diseases like type 2 diabetes.
Objective: To investigate the relationship between ACE I/D polymorphism and type 2 diabetes in 261 Iranian casecontrol pairs.
Methods: 170 patients (85 type 2 diabetics with nephropathy and 85 type 2 diabetics without nephropathy) and 91 healthy control subjects were enrolled in our study. I/D polymorphism of the ACE gene was detected by polymerase chain reaction (PCR) utilizing specific primers.
Results: The frequency of DD genotype in the DN group was higher than that of the type 2 diabetic patients (30.6% vs. 20%, P =0.157) and the control group (30.6% vs. 14.3%, P=0.006). The frequency of D allele in nephropathic patients was 58.2% as compared to type 2 diabetic patients without nephropathy 50.5% (P=0.19) and control subjects 37.3% (P =0.001). Therefore, the frequency of DD genotype and D allele significantly increased in DN patients in comparison to healthy controls.
Conclusion: It is concluded that the DD genotype and/or D allele of ACE gene may increase the risk for type 2 diabetes but not diabetic nephropathy.
کلیدواژه‌ها
Angiotensin Converting Enzyme؛ Type 2 Diabetes؛ Nephropathy
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