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Effects of Recombinant Human Erythropoietin Pretreatment on Anti-HLA Antibody Titer: A Preclinical Experience in Rats | ||
| Iranian Journal of Immunology | ||
| مقاله 4، دوره 2، شماره 4 - شماره پیاپی 7، اسفند 2005، صفحه 208-212 اصل مقاله (61.85 K) | ||
| نوع مقاله: Original Article | ||
| نویسندگان | ||
| Akbar Vahdati1؛ Minoo Adib2؛ Shirin Kashfi* 1؛ Taji Afrooz1؛ Edna Abkar3 | ||
| 1Biology Department, Faculty of Sciences, Isfahan University, Isfahan | ||
| 2Immunology Department, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, | ||
| 3Immunogenetics Lab., Ali Asghar hospital, Isfahan, Iran | ||
| چکیده | ||
| Background: Erythropoietin (EPO) was first known as a factor for red blood cell proliferation and differentiation. New studies show the effects of EPO on immune system. Objective: In this study, the effects of pretreatment with recombinant human erythropoietin (rHuEPO) on the anti-human leukocyte antibody (anti-HLA) titer were determined. Methods: Three groups of rats were sensitized with human lymphocytes. Two of the groups were given 20 or 100 IU/Kg rHuEPO after two sensitizations with human lymphocytes. Control group did not receive rHuEPO. Microlymphocytotoxicity method was used to detect anti-HLA antibodies. Results: Treatment with rHuEPO caused a significant decline in anti-HLA antibody titer compared to control group. Also, pretreatment with rHuEPO suppressed antibody response after repeated antigenic stimulation. Conclusion: Such results could be due to the effects of rHuEPO on the number or the activity of the B and the T cells. Moreover, the dose of rHuEPO and the length of treatment might affect anti-HLA antibody titer. | ||
| کلیدواژه‌ها | ||
| Anti-HLA Antibody Titer؛ rHuEPO؛ Lymphocytes | ||
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آمار تعداد مشاهده مقاله: 927 تعداد دریافت فایل اصل مقاله: 715 |
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