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Khalili, Ghader, Dobakhti, Faramarz, Mahmoudzadeh Niknam, Hamid, Khaze, Vahid, Partovi, Fatemeh. (1389). Immunotherapy with Imiquimod Increases the Efficacy of Glucantime Therapy of Leishmania major Infection. سامانه مدیریت نشریات علمی, 8(1), 45-51.
Ghader Khalili; Faramarz Dobakhti; Hamid Mahmoudzadeh Niknam; Vahid Khaze; Fatemeh Partovi. "Immunotherapy with Imiquimod Increases the Efficacy of Glucantime Therapy of Leishmania major Infection". سامانه مدیریت نشریات علمی, 8, 1, 1389, 45-51.
Khalili, Ghader, Dobakhti, Faramarz, Mahmoudzadeh Niknam, Hamid, Khaze, Vahid, Partovi, Fatemeh. (1389). 'Immunotherapy with Imiquimod Increases the Efficacy of Glucantime Therapy of Leishmania major Infection', سامانه مدیریت نشریات علمی, 8(1), pp. 45-51.
Khalili, Ghader, Dobakhti, Faramarz, Mahmoudzadeh Niknam, Hamid, Khaze, Vahid, Partovi, Fatemeh. Immunotherapy with Imiquimod Increases the Efficacy of Glucantime Therapy of Leishmania major Infection. سامانه مدیریت نشریات علمی, 1389; 8(1): 45-51.

Immunotherapy with Imiquimod Increases the Efficacy of Glucantime Therapy of Leishmania major Infection

Iranian Journal of Immunology
مقاله 6، دوره 8، شماره 1، خرداد 2011، صفحه 45-51    اصل مقاله (183.42 K)
نوع مقاله: Original Article
نویسندگان
Ghader Khalili1؛ Faramarz Dobakhti2؛ Hamid Mahmoudzadeh Niknam1؛ Vahid Khaze1؛ Fatemeh Partovi3
1Department of Immunology, Pasteur Institute of Iran, Tehran, Iran
2School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
3Faculty of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background: Leishmaniasis is a complex disease which presents as visceral, cutaneous and mucocutaneous forms. The current treatment options for this infection are very limited and the immunological state of the host appears to play an important role in the efficacy of the treatment. Immunostimulation through immune response activating agents such as Imiquimod is another rational approach for this purpose.
Objective: We assessed the efficacy of immunotherapy with Imiquimod alone or combined with Glucantime for treatment of Leishmania major infection in BALB/c mice.
Methods: Treatment efficacy was monitored by determination of thickness and parasite load of infected footpad of mice.
Results: The footpad thickness revealed that treatment with Imiquimod plus Glucantime has the highest efficacy. The results were confirmed by parasite load of infected footpad. Our data shows that treatment of Leishmania major infection in BALB/c mice by the combined Imiquimod and Glucantime is more efficient than each drug alone.
Conclusion: The combination of Imiquimod with chemotherapy may offer a way for more efficient treatment of leishmaniasis.
کلیدواژه‌ها
BALB/c Mice؛ glucantime؛ Imiquimod؛ Leishmania Major
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