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Toomarian, Lida, Sattari, Mandana, Hashemi, Nazanin, Tadayon, Nikoo, Akbarzadeh Baghban, Alireza. (1389). Comparison of Neutrophil Apoptosis α-Defensins and Calprotectin in Children with and without Severe Early Childhood Caries. سامانه مدیریت نشریات علمی, 8(1), 11-19. doi: Immune attributes in S-ECC
Lida Toomarian; Mandana Sattari; Nazanin Hashemi; Nikoo Tadayon; Alireza Akbarzadeh Baghban. "Comparison of Neutrophil Apoptosis α-Defensins and Calprotectin in Children with and without Severe Early Childhood Caries". سامانه مدیریت نشریات علمی, 8, 1, 1389, 11-19. doi: Immune attributes in S-ECC
Toomarian, Lida, Sattari, Mandana, Hashemi, Nazanin, Tadayon, Nikoo, Akbarzadeh Baghban, Alireza. (1389). 'Comparison of Neutrophil Apoptosis α-Defensins and Calprotectin in Children with and without Severe Early Childhood Caries', سامانه مدیریت نشریات علمی, 8(1), pp. 11-19. doi: Immune attributes in S-ECC
Toomarian, Lida, Sattari, Mandana, Hashemi, Nazanin, Tadayon, Nikoo, Akbarzadeh Baghban, Alireza. Comparison of Neutrophil Apoptosis α-Defensins and Calprotectin in Children with and without Severe Early Childhood Caries. سامانه مدیریت نشریات علمی, 1389; 8(1): 11-19. doi: Immune attributes in S-ECC

Comparison of Neutrophil Apoptosis α-Defensins and Calprotectin in Children with and without Severe Early Childhood Caries

Iranian Journal of Immunology
مقاله 2، دوره 8، شماره 1، خرداد 2011، صفحه 11-19    اصل مقاله (194.13 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): Immune attributes in S-ECC
نویسندگان
Lida Toomarian* 1؛ Mandana Sattari2؛ Nazanin Hashemi1؛ Nikoo Tadayon1؛ Alireza Akbarzadeh Baghban3
1Department of Pediatric Dentistry, Dental School
2Department of Immunology, Shahid Beheshti University of Medical Sciences
3Department of Biostatics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background: The infectious nature of severe early-childhood caries (S-ECC) points to the possible participation of immunologic host responses including neutrophils and their antimicrobial products.
Objectives: The aim of this study was to determine the neutrophil apoptosis, α-defensins (HNP1-3) and calprotectin levels in the saliva of preschool children and the association with S-ECC.
Methods: Oral examinations were performed on 87 children aged 3-5 years and non stimulated whole saliva samples were collected. Thirty of these subjects were considered S-ECC children, 30 with moderate caries (MC) and 27 were caries free (CF). To detect apoptosis, cell staining was done with Annexin-V-Fluos and propidium iodide, and they were analyzed by fluorescent microscopy. The concentration of α-defensins and calprotectin were assessed using ELISA.
Results: There were no statistical differences between groups considering the HNP1-3 or calprotectin salivary levels (p=0.06 and p=0.23, respectively). The HNP1-3 and calprotectin levels were negatively correlated and the correlation was significant in MC group (p=0.03). Lower levels of apoptotic neutrophils were obtained from CF subjects as compared with S-ECC children (p=0.03).
Conclusions: Our findings establish that apoptotic mechanisms could be implicated in the immunity responses associated with S-ECC. We cannot yet
کلیدواژه‌ها
Severe Early Childhood Caries؛ apoptosis؛ α-Defensins؛ Calprotectin؛ Neutrophil
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