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Sheikh Sajjadieh, Mohammad Reza, Kuznetsova, Larisa, Bojenko, vadim. (1391). Cytokine Status in Ukrainian Children with Irritable Bowel Syndrome Residing in a Radioactive Contaminated Area. سامانه مدیریت نشریات علمی, 9(4), 248-253.
Mohammad Reza Sheikh Sajjadieh; Larisa Kuznetsova; vadim Bojenko. "Cytokine Status in Ukrainian Children with Irritable Bowel Syndrome Residing in a Radioactive Contaminated Area". سامانه مدیریت نشریات علمی, 9, 4, 1391, 248-253.
Sheikh Sajjadieh, Mohammad Reza, Kuznetsova, Larisa, Bojenko, vadim. (1391). 'Cytokine Status in Ukrainian Children with Irritable Bowel Syndrome Residing in a Radioactive Contaminated Area', سامانه مدیریت نشریات علمی, 9(4), pp. 248-253.
Sheikh Sajjadieh, Mohammad Reza, Kuznetsova, Larisa, Bojenko, vadim. Cytokine Status in Ukrainian Children with Irritable Bowel Syndrome Residing in a Radioactive Contaminated Area. سامانه مدیریت نشریات علمی, 1391; 9(4): 248-253.

Cytokine Status in Ukrainian Children with Irritable Bowel Syndrome Residing in a Radioactive Contaminated Area

Iranian Journal of Immunology
مقاله 5، دوره 9، شماره 4، اسفند 2012، صفحه 248-253    اصل مقاله (183.31 K)
نوع مقاله: Original Article
نویسندگان
Mohammad Reza Sheikh Sajjadieh* 1، 2؛ Larisa Kuznetsova1؛ vadim Bojenko2
1Department of Clinical Immunology and Allergology, National Medical Academy for Post Graduate Education
2Ukrainian Specialized Dispensaries of Radiation Defend Population, Kiev, Ukraine
چکیده
Background: The effect of low dose radiation on immune system is shown. Ionizing radiation can affect cytokine production and polarization of T helper cells.
Objective: The current study focused on ionizing radiation in Ukrainian children residing in a contaminated area with clinical irritable bowel syndrome.
Method: Our study included 75 rural children population aged 4-18 yrs, who lived in a contaminated area exposed to natural environmental radiation with clinical irritable bowel syndrome (categorized in three groups) and 20 rural children participants aged 5-15 yrs who were living in areas with similar levels of radioactive contamination without clinical irritable bowel syndrome as control group. Internal radiation activity was measured by gamma-ray spectrometry. Serum levels of IL-4 and IFN-γ were measured by enzyme linked immunosorbent assay.
Results: A trend towards increased levels of IL-4 was observed in children with clinical irritable bowel syndrome. In these children, IFN-γ levels were lower than that of the control group.
Conclusion: The IBS symptoms in Ukrainian children residing in a contaminated area may have stemmed from Th1 to Th2 immune deviation and differential expression of IL-4 and IFN-γ.
کلیدواژه‌ها
Chernobyl Children؛ Ionizing radiation؛ Th2 Response؛ Irritable bowel syndrome
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