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Erfani, Nasrollah, Moghaddasi-Sani, Faezeh, Razmkhah, Mahboubeh, Haghshenas, Mohammad Reza, Talaei, Abdolrasoul, Ghaderi, Abbas. (1391). CCL22 16C/A Genetic Variation is not Associated with Breast Carcinoma in Southern Iranian Population. سامانه مدیریت نشریات علمی, 9(4), 226-233.
Nasrollah Erfani; Faezeh Moghaddasi-Sani; Mahboubeh Razmkhah; Mohammad Reza Haghshenas; Abdolrasoul Talaei; Abbas Ghaderi. "CCL22 16C/A Genetic Variation is not Associated with Breast Carcinoma in Southern Iranian Population". سامانه مدیریت نشریات علمی, 9, 4, 1391, 226-233.
Erfani, Nasrollah, Moghaddasi-Sani, Faezeh, Razmkhah, Mahboubeh, Haghshenas, Mohammad Reza, Talaei, Abdolrasoul, Ghaderi, Abbas. (1391). 'CCL22 16C/A Genetic Variation is not Associated with Breast Carcinoma in Southern Iranian Population', سامانه مدیریت نشریات علمی, 9(4), pp. 226-233.
Erfani, Nasrollah, Moghaddasi-Sani, Faezeh, Razmkhah, Mahboubeh, Haghshenas, Mohammad Reza, Talaei, Abdolrasoul, Ghaderi, Abbas. CCL22 16C/A Genetic Variation is not Associated with Breast Carcinoma in Southern Iranian Population. سامانه مدیریت نشریات علمی, 1391; 9(4): 226-233.

CCL22 16C/A Genetic Variation is not Associated with Breast Carcinoma in Southern Iranian Population

Iranian Journal of Immunology
مقاله 2، دوره 9، شماره 4، اسفند 2012، صفحه 226-233    اصل مقاله (310.2 K)
نوع مقاله: Original Article
نویسندگان
Nasrollah Erfani1؛ Faezeh Moghaddasi-Sani2؛ Mahboubeh Razmkhah1؛ Mohammad Reza Haghshenas1؛ Abdolrasoul Talaei3؛ Abbas Ghaderi* 1، 4
1Cancer Immunology Research Group, Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz
2Department of Biology, Faculty of Sciences, Islamic Azad University-Science and Research Branch, Tehran
3Department of Surgery
4Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: CCL22/MDC is a CC chemokine with a critical role in regulation of the immune balance in physiological condition. CCL22/CCR-4 ligation has been documented to participate in the migration of regulatory T (Treg) cells and Th2 lymphocytes to the site of breast tumors; circumstances that are known to be associated with poor prognosis.
Objective: To investigate the association of a single nucleotide polymorphism (SNP) in CCL22 gene; 16C/A (rs4359426; Asp2Ala), with susceptibility to breast cancer in a sample of Iranian population.
Methods: 161 patients with pathologically confirmed breast carcinoma (mean age 49.3 ± 11.5 yrs) and 178 agematched healthy women (mean age: 49.3 ± 12.9 yrs) were studied. CCL22 genotypes were investigated by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. Data was verified by direct automated sequencing. Arlequin analysis showed no deviation from Hardy-Weinberg equilibrium.
Results: The most frequent genotype in both patient and control groups was wild type CC genotype with frequency of 146 out of 161 (90.7%) among patients and 153 out of 178 (86.0%) in control group (p=0.24). The frequency of CA genotype was 15 (9.3%) and 23 (12.9%) in patients and controls, respectively (p=0.38). No AA genotype was observed among patients but this genotype was observed with the frequency of 2 out of 178 (1.1%) in control subjects. The minor allele frequency (MAF) was 0.07 in the population.
Conclusion: No correlation was found between the investigated genotypes and clinicopathological characteristics of the patients. Conclusively, results of this investigation do not support the association of 16C/A SNP (rs4359426; Asp2Ala) in CCL22 gene with susceptibility to, and progression of, breast cancer in Iranian population.
کلیدواژه‌ها
Breast cancer؛ CCL22/MDC؛ Immunology؛ Chemokine؛ Polymorphism؛ tumor
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