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Rafiei, Alireza, Abedini, Mahoud, Hosseini, Seyed Hamzeh, HosseiniKhah, Zahra, Bazrafshan, Behrouz, Tehrani, Mohsen. (1391). Toll Like Receptor-4 896A/G Gene Variation, a Risk Factor for Migraine Headaches. سامانه مدیریت نشریات علمی, 9(3), 159-167.
Alireza Rafiei; Mahoud Abedini; Seyed Hamzeh Hosseini; Zahra HosseiniKhah; Behrouz Bazrafshan; Mohsen Tehrani. "Toll Like Receptor-4 896A/G Gene Variation, a Risk Factor for Migraine Headaches". سامانه مدیریت نشریات علمی, 9, 3, 1391, 159-167.
Rafiei, Alireza, Abedini, Mahoud, Hosseini, Seyed Hamzeh, HosseiniKhah, Zahra, Bazrafshan, Behrouz, Tehrani, Mohsen. (1391). 'Toll Like Receptor-4 896A/G Gene Variation, a Risk Factor for Migraine Headaches', سامانه مدیریت نشریات علمی, 9(3), pp. 159-167.
Rafiei, Alireza, Abedini, Mahoud, Hosseini, Seyed Hamzeh, HosseiniKhah, Zahra, Bazrafshan, Behrouz, Tehrani, Mohsen. Toll Like Receptor-4 896A/G Gene Variation, a Risk Factor for Migraine Headaches. سامانه مدیریت نشریات علمی, 1391; 9(3): 159-167.

Toll Like Receptor-4 896A/G Gene Variation, a Risk Factor for Migraine Headaches

Iranian Journal of Immunology
مقاله 2، دوره 9، شماره 3، آذر 2012، صفحه 159-167    اصل مقاله (235.49 K)
نوع مقاله: Original Article
نویسندگان
Alireza Rafiei1؛ Mahoud Abedini* 2؛ Seyed Hamzeh Hosseini3؛ Zahra HosseiniKhah1؛ Behrouz Bazrafshan2؛ Mohsen Tehrani1
1Molecular and Cell Biology Research Center, Sari Medical School
2Neurology Ward, Department of Internal Medicine, Buali Hospital
3Psychiatry and Behavioral Research Center, Zare Hospital, Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran
چکیده
Background: The pathogenesis of migraine involves immune-mediated mechanisms in the vascular endothelium. Toll like receptor 4 (TLR-4) is a signaling receptor of innate immunity which plays a role in various neuropathologies related to neuron inflammation.
Objective: This case/control study is aimed to investigate whether TLR- 4 896A/G variation is related to migraine headaches in an Iranian population.
Methods: A total of 170 migraine patients (130 females, mean age 33.24 ± 11 years) and 170 age, sex, and ethnicity matched healthy controls (118 females, mean age of 31 ± 10 years) were recruited. Genotyping was carried out using the tetra primer amplification refractory mutation system (ARMS)-PCR.
Results: The frequency of G allele was higher in migraine patients than the controls (15% vs. 4.7%; p<0.0001). Interestingly, the distribution of heterozygous 896A/G genotype statistically differed between migraineurs and controls (25.3% vs. 8.2%, p=0.00002, OR 3.87, 95% CI; 2.02-7.4). Multivariate logistic regression analysis indicated that G allele in affected female migraineurs is an independent factor associated with increased risk of migraine (OR 3.2, 95% CI 1.23-8.24, p=0.01).
Conclusion: Our results showed TLR-4 polymorphism as a genetic risk factor for migraine. However, further studies in different populations are required to elucidate the precise role of TLR-4 896A/G mutation in susceptibility to migraine.
کلیدواژه‌ها
Female؛ Genetic Polymorphism؛ Receptor؛ Inflammation؛ migraine؛ Toll like
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