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Hayatbakhsh, Mohammad Mahdi, Zahedi, Mohammad Javad, Shafiepour, Mohsen, Nikpoor, Amin Reza, Mohammadi, Mojgan. (1391). IL-23 Receptor Gene rs7517847 and rs1004819 SNPs in Ulcerative Colitis. سامانه مدیریت نشریات علمی, 9(2), 128-135.
Mohammad Mahdi Hayatbakhsh; Mohammad Javad Zahedi; Mohsen Shafiepour; Amin Reza Nikpoor; Mojgan Mohammadi. "IL-23 Receptor Gene rs7517847 and rs1004819 SNPs in Ulcerative Colitis". سامانه مدیریت نشریات علمی, 9, 2, 1391, 128-135.
Hayatbakhsh, Mohammad Mahdi, Zahedi, Mohammad Javad, Shafiepour, Mohsen, Nikpoor, Amin Reza, Mohammadi, Mojgan. (1391). 'IL-23 Receptor Gene rs7517847 and rs1004819 SNPs in Ulcerative Colitis', سامانه مدیریت نشریات علمی, 9(2), pp. 128-135.
Hayatbakhsh, Mohammad Mahdi, Zahedi, Mohammad Javad, Shafiepour, Mohsen, Nikpoor, Amin Reza, Mohammadi, Mojgan. IL-23 Receptor Gene rs7517847 and rs1004819 SNPs in Ulcerative Colitis. سامانه مدیریت نشریات علمی, 1391; 9(2): 128-135.

IL-23 Receptor Gene rs7517847 and rs1004819 SNPs in Ulcerative Colitis

Iranian Journal of Immunology
مقاله 6، دوره 9، شماره 2، شهریور 2012، صفحه 128-135    اصل مقاله (293.73 K)
نوع مقاله: Original Article
نویسندگان
Mohammad Mahdi Hayatbakhsh1؛ Mohammad Javad Zahedi1؛ Mohsen Shafiepour1؛ Amin Reza Nikpoor2؛ Mojgan Mohammadi* 3، 2
1Department of Gastroenterology, Afzalipour Hospital
2Department of Microbiology, Virology and Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran
3Physiology Research Centre
چکیده
Background: Crohn’s disease (CD) and ulcerative colitis (UC) are two major clinical presentations of inflammatory bowel disease (IBD). Many novel candidate genes have been found to be associated with increased risk for IBD. Recently IL-23 receptor gene is identified as an IBD associated gene in genome-wide studies.
Objective: To ascertain whether rs7517847 and rs1004819 SNPs in the IL-23 receptor gene are associated with UC in our population in Kerman, south east of Iran.
Methods: A total of 85 patients with UC and 100 healthy controls enrolled in our study. Endoscopic procedure was performed for all patients to determine their disease severity. IL-23 receptor genotyping at positions rs7517847 and rs1004819 was done by PCR-RFLP technique.
Results: The results of this study showed no association between the studied polymorphisms in the IL-23 receptor gene and UC in our population. However, we found a significant association between rs7517847 gene polymorphism in IL-23 receptor and two important clinical variables including blood in stool and bowel movements in UC patients.
Conclusion: The rs7517847 gene polymorphism in IL-23R may be related to the presence of blood in stool and bowel movements in patients with UC. Further functional analysis with other known IL-23 receptor genotypes and/or other candidate genes is necessary to confirm any genetic association with UC in our population.
کلیدواژه‌ها
IL-23R؛ rs7517847؛ rs1004819؛ Ulcerative colitis
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