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Genistein Induces a Protective Immunomodulatory Effect in a Mouse Model of Cervical Cancer | ||
Iranian Journal of Immunology | ||
مقاله 5، دوره 9، شماره 2، شهریور 2012، صفحه 119-127 اصل مقاله (700.52 K) | ||
نوع مقاله: Original Article | ||
نویسندگان | ||
Ali Ghasemi* 1، 2؛ Hoorieh Soleimanjahi3؛ Soodeh Razeghi4؛ Ali Gorji2، 5؛ Alijan Tabaraei1؛ Abdolvahab Moradi1؛ Akram Alizadeh6؛ Mohammad Ali Vakili7 | ||
1Department of Microbiology, School of Medicine, Infectious Diseases research Centre, Golestan University of Medical Sciences, Gorgan | ||
2Shefa Neuroscience Research Centre | ||
3Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University | ||
4Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran | ||
5Institut für Physiologie I, Westfälische Wilhelms-Universität Münster, RobertKoch-Strasse Münster, Germany | ||
6Department of Advanced Technology, Tehran University of Medical Sciences, Tehran | ||
7Department of Health and Social Sciences, Golestan University of Medical Sciences, Gorgan, Iran | ||
چکیده | ||
Background: Genistein (GEN), a naturally occurring flavonoid present in soy bean, has attracted scientific interest for its possible benefits in cancer. Objective: The potential immunomodulatory effects of genistein on the immune system and against TC-1 tumor cell line were evaluated in adult female C57BL/6 mice. Methods: Mice were treated with GEN 10 days before to 10 days after the tumor induction. Thirty days after the last GEN treatment, lymphocyte proliferation, Lactase Dehydrogenase (LDH) cytolytic activity and cytokine secretion were analyzed in GEN and control groups. Results: The results showed that ingestion of genistein significantly increased lymphocyte proliferation and LDH release. Furthermore, the treatment with genistein also caused a significant increment in interferon gamma (IFN-γ). In addition, the treatment achieved significant therapeutic effect in tumor models compared to the control group. These results indicated that the effect of GEN on tumor growth may be attributed to its effect on lymphocyte proliferation, cytolytic activity and IFN-γ production. Conclusion: These results demonstrate that GEN exerts an immunomodulatory effect in a mouse model of Human Papillomavirus (HPV) associated-cervical cancer. | ||
کلیدواژهها | ||
Cervical Cancer؛ Genistein؛ TC-1؛ Human papillomavirus؛ Imunomodulation | ||
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