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Rezaee, Mohammad Ali, Motaharinia, Yousef, Hosseini, Werya, Jalili, Ali, Rashidi, Ahmad, Mosavi, Bita, Zamini, Ghasem, Rahmani, Mohammad Reza. (1391). Natural Oils Enhance IL-10 and IFN-γ Production by Human PBMCs Cultured with Malassezia furfur. سامانه مدیریت نشریات علمی, 9(2), 109-118.
Mohammad Ali Rezaee; Yousef Motaharinia; Werya Hosseini; Ali Jalili; Ahmad Rashidi; Bita Mosavi; Ghasem Zamini; Mohammad Reza Rahmani. "Natural Oils Enhance IL-10 and IFN-γ Production by Human PBMCs Cultured with Malassezia furfur". سامانه مدیریت نشریات علمی, 9, 2, 1391, 109-118.
Rezaee, Mohammad Ali, Motaharinia, Yousef, Hosseini, Werya, Jalili, Ali, Rashidi, Ahmad, Mosavi, Bita, Zamini, Ghasem, Rahmani, Mohammad Reza. (1391). 'Natural Oils Enhance IL-10 and IFN-γ Production by Human PBMCs Cultured with Malassezia furfur', سامانه مدیریت نشریات علمی, 9(2), pp. 109-118.
Rezaee, Mohammad Ali, Motaharinia, Yousef, Hosseini, Werya, Jalili, Ali, Rashidi, Ahmad, Mosavi, Bita, Zamini, Ghasem, Rahmani, Mohammad Reza. Natural Oils Enhance IL-10 and IFN-γ Production by Human PBMCs Cultured with Malassezia furfur. سامانه مدیریت نشریات علمی, 1391; 9(2): 109-118.

Natural Oils Enhance IL-10 and IFN-γ Production by Human PBMCs Cultured with Malassezia furfur

Iranian Journal of Immunology
مقاله 4، دوره 9، شماره 2، شهریور 2012، صفحه 109-118    اصل مقاله (669.01 K)
نوع مقاله: Original Article
نویسندگان
Mohammad Ali Rezaee1؛ Yousef Motaharinia1؛ Werya Hosseini1؛ Ali Jalili1؛ Ahmad Rashidi1؛ Bita Mosavi2؛ Ghasem Zamini2؛ Mohammad Reza Rahmani* 1
1Department of Immunology
2Department of Mycology and Parasitology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
چکیده
Background: Malassezia furfur is alipophilic yeast that causes skin disease.
Objective: To evaluate the level of IL-10, IFN-γ and IL-12P70 in co-incubation of M. furfur grown on different forms of natural oils with PBMCs of healthy individuals.
Methods: PBMCs were obtained from blood samples of normal volunteers. M. furfur was cultured in different culture media containing almond oil, fish oil, walnut oil, full-fat milk, and a fat-free medium; and the yeasts grown were harvested and used for co-incubation with PBMCs in vitro. The IFN-γ, IL-10, and IL-12P70 levels were measured at different time intervals using ELISA methods.
Results: Generally, IFN-γ and IL-10 levels in the coincubation of yeasts with walnut oil group (WOG) and fish oil group (FOG) were higher than those in the almond oil group (AOG) and full-fat milk group (FFMG). Although the IL-12P70 was higher in groups such as AOG, FOG, and WOG; the increase was not statistically significant.
Conclusion: The results demonstrated that the type of fat used by M. furfur in the culture media can influence the immune response and increases IFN-γ and IL-10 levels in an early time point of the culture system.
کلیدواژه‌ها
IL-10؛ IFN-؛ IL-12؛ Malassezia furfur؛ Natural Oil؛ PBMC
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