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Memarian, Ali, Vosough, Parvaneh, Asgarian-Omran, Hossein, Tabrizi, Mina, Shabani, Mahdi, Shokri, Fazel. (1390). Differential WNT Gene Expression in Various Subtypes of Acute Lymphoblastic Leukemia. سامانه مدیریت نشریات علمی, 9(1), 61-71.
Ali Memarian; Parvaneh Vosough; Hossein Asgarian-Omran; Mina Tabrizi; Mahdi Shabani; Fazel Shokri. "Differential WNT Gene Expression in Various Subtypes of Acute Lymphoblastic Leukemia". سامانه مدیریت نشریات علمی, 9, 1, 1390, 61-71.
Memarian, Ali, Vosough, Parvaneh, Asgarian-Omran, Hossein, Tabrizi, Mina, Shabani, Mahdi, Shokri, Fazel. (1390). 'Differential WNT Gene Expression in Various Subtypes of Acute Lymphoblastic Leukemia', سامانه مدیریت نشریات علمی, 9(1), pp. 61-71.
Memarian, Ali, Vosough, Parvaneh, Asgarian-Omran, Hossein, Tabrizi, Mina, Shabani, Mahdi, Shokri, Fazel. Differential WNT Gene Expression in Various Subtypes of Acute Lymphoblastic Leukemia. سامانه مدیریت نشریات علمی, 1390; 9(1): 61-71.

Differential WNT Gene Expression in Various Subtypes of Acute Lymphoblastic Leukemia

Iranian Journal of Immunology
مقاله 6، دوره 9، شماره 1، خرداد 2012، صفحه 61-71    اصل مقاله (499 K)
نوع مقاله: Original Article
نویسندگان
Ali Memarian1؛ Parvaneh Vosough2؛ Hossein Asgarian-Omran1؛ Mina Tabrizi3؛ Mahdi Shabani4؛ Fazel Shokri* 1، 4
1Department of Immunology, School of Public Health
2Clinic of Hematology and Oncology, Ali-Asghar Hospital, Faculty of Medicine
3Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences
4Monoclonal Antibody Research Center, Avicenna Research Institute, Tehran, Iran
چکیده
Background: Dysregulation of WNT signaling has been reported in many malignancies.
Objective: This study was conducted to investigate the expression pattern of 14 members of the WNT gene family in different immunophenotypic subtypes of ALL.
Methods: Semi-quantitative RT-PCR was performed on samples from 71 ALL patients and 36 age-matched healthy individuals. The ALL patients were categorized into BALL (76%), T-ALL (22.6%) and mixed lineage (1.4%) and the B-ALL cases were further classified into pro-B, pre-BI, pre-BII and immature/mature-B based on immunophenotypic results.
Results: Among the WNT genes, WNT-7B (p=0.026), WNT-9A (p=0.020) and WNT-16B (p=0.023) were significantly over-expressed, whereas WNT- 2B (p=0.033), WNT-5A (p=0.016), WNT-7A (p<0.0001) and WNT-10A (p<0.0001) were down-regulated in B-ALL. Among the T-ALL subtype, however, significant down-regulation of WNT-2B, WNT-5B, WNT-7A, WNT-10A and WNT-11 was evident. Comparison between B-ALL subtypes showed significant over-expression of WNT-7B, WNT-9A and WNT-5B in certain subtypes.
Conclusion: Our results suggest contribution of the WNT genes in leukemogenesis of ALL.
کلیدواژه‌ها
Acute Lymphoblastic Leukemia؛ Immunophenotype؛ RT-PCR؛ Wnt
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