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Fattahi, Mohammad Javad, Pezeshki, Abdul Mohammad, Emad, Maryam, Lohrasb, Mohammad Hosein, Shamseddin, Azra, Ghaderi, Abbas, Doroudchi, Mehrnoosh. (1384). Lack of Association between ctla-4 A49G Polymorphism and Vitiligo. سامانه مدیریت نشریات علمی, 2(2), 97-102.
Mohammad Javad Fattahi; Abdul Mohammad Pezeshki; Maryam Emad; Mohammad Hosein Lohrasb; Azra Shamseddin; Abbas Ghaderi; Mehrnoosh Doroudchi. "Lack of Association between ctla-4 A49G Polymorphism and Vitiligo". سامانه مدیریت نشریات علمی, 2, 2, 1384, 97-102.
Fattahi, Mohammad Javad, Pezeshki, Abdul Mohammad, Emad, Maryam, Lohrasb, Mohammad Hosein, Shamseddin, Azra, Ghaderi, Abbas, Doroudchi, Mehrnoosh. (1384). 'Lack of Association between ctla-4 A49G Polymorphism and Vitiligo', سامانه مدیریت نشریات علمی, 2(2), pp. 97-102.
Fattahi, Mohammad Javad, Pezeshki, Abdul Mohammad, Emad, Maryam, Lohrasb, Mohammad Hosein, Shamseddin, Azra, Ghaderi, Abbas, Doroudchi, Mehrnoosh. Lack of Association between ctla-4 A49G Polymorphism and Vitiligo. سامانه مدیریت نشریات علمی, 1384; 2(2): 97-102.

Lack of Association between ctla-4 A49G Polymorphism and Vitiligo

Iranian Journal of Immunology
مقاله 5، دوره 2، شماره 2 - شماره پیاپی 5، شهریور 2005، صفحه 97-102    اصل مقاله (298.4 K)
نوع مقاله: Original Article
نویسندگان
Mohammad Javad Fattahi1؛ Abdul Mohammad Pezeshki2؛ Maryam Emad3؛ Mohammad Hosein Lohrasb4؛ Azra Shamseddin5؛ Abbas Ghaderi1، 2؛ Mehrnoosh Doroudchi* 1، 2
1Department of Immunology
2Shiraz Institute for Cancer Research
3Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Immunology and
5Dermatology, Fasa Medical School, Fasa, Iran
چکیده
Background: Vitiligo is an acquired skin disorder that selectively destroys melanocytes in epidermis with an unknown etiology.  
Objective: To investigate the exon 1 A49G polymorphism of cytotoxic T lymphocyte antigen-4 (ctla-4) gene in vitiligo patients.  
Methods: The A49G polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method in 101 patients and 208 normal healthy age/ethnicity matched individuals.  
Results: The frequencies of heterozygote genotypes in patients and controls were found to be 42 (41.6%) of 101 and 85 (40.9%) of 208, respectively. The frequencies of homozygote A and G genotypes were 49 (48.5%) and 10 (9.9%) in 101 patients, whereas, these frequencies in 208 control individuals were 103 (49.5%) and 20 (9.6%), respectively. There was no significant difference between the genotype (P = 0.98) and allele (P = 0.86) frequencies of A49G polymorphism in patients and normal healthy individuals.  
Conclusion: Our results indicate that in contrast to several immune mediated disorders, there is no association between ctla-4 A49G gene polymorphism and vitiligo.
کلیدواژه‌ها
Autoimmune؛ ctla-4؛ Melanocyte؛ PCR-RFLP؛ Polymorphism؛ Vitiligo
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