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Orazizadeh, Mahmoud, Salter, Donald M. (1384). Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage. سامانه مدیریت نشریات علمی, 2(2), 78-86.
Mahmoud Orazizadeh; Donald M Salter. "Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage". سامانه مدیریت نشریات علمی, 2, 2, 1384, 78-86.
Orazizadeh, Mahmoud, Salter, Donald M. (1384). 'Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage', سامانه مدیریت نشریات علمی, 2(2), pp. 78-86.
Orazizadeh, Mahmoud, Salter, Donald M. Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage. سامانه مدیریت نشریات علمی, 1384; 2(2): 78-86.

Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage

Iranian Journal of Immunology
مقاله 2، دوره 2، شماره 2 - شماره پیاپی 5، شهریور 2005، صفحه 78-86    اصل مقاله (1.24 M)
نوع مقاله: Original Article
نویسندگان
Mahmoud Orazizadeh* 1؛ Donald M Salter2
1Department of Histology, Medical School, Ahwaz Jondishapour University of Medical Sciences (AJUMS), Ahwaz, Iran
2Department of Pathology, Medical School, Edinburgh University, Edinburgh, Scotland, UK
چکیده
Background: Previous studies have shown that Galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones.  
Objective: In the present work, the expression pattern of Galectin-3 in normal and various grades of osteoarthritic (OA) human articular cartilage has been studied.  
Methods: Using immunohistochemistry and standard western blotting, the in vivo and in vitro expression pattern of Galectin-3 in normal and OA human articular cartilage were assessed.  
Results: Immunohistochemical studies showed a similar pattern of Galectin-3 expression in normal and mild OA but severe OA showed different strong expression in all zones of human articular cartilage.  
Conclusion: Increased expression pattern of Galectin-3 in advanced stages of OA may occur as a result of the imbalance of chondrocyte homeostasis that occurs in OA cartilage and provides a condition to modify normal chondrocyte to an OA chondroctye.
کلیدواژه‌ها
Articular Cartilage؛ Galectin-3؛ Osteoarthritis
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