LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,089
تعداد مقالات9,999
تعداد مشاهده مقاله26,587,579
تعداد دریافت فایل اصل مقاله7,314,422
Ayatollahi, Maryam, Samsami Dehaghani, Alamtaj, Tabei, Ziaedin. (1383). Maternal Serum Levels of Transforming Growth Factor ß1 (TGF-ß1) in Normal and Preeclamptic Pregnancies. سامانه مدیریت نشریات علمی, 2(1), 50-55.
Maryam Ayatollahi; Alamtaj Samsami Dehaghani; Ziaedin Tabei. "Maternal Serum Levels of Transforming Growth Factor ß1 (TGF-ß1) in Normal and Preeclamptic Pregnancies". سامانه مدیریت نشریات علمی, 2, 1, 1383, 50-55.
Ayatollahi, Maryam, Samsami Dehaghani, Alamtaj, Tabei, Ziaedin. (1383). 'Maternal Serum Levels of Transforming Growth Factor ß1 (TGF-ß1) in Normal and Preeclamptic Pregnancies', سامانه مدیریت نشریات علمی, 2(1), pp. 50-55.
Ayatollahi, Maryam, Samsami Dehaghani, Alamtaj, Tabei, Ziaedin. Maternal Serum Levels of Transforming Growth Factor ß1 (TGF-ß1) in Normal and Preeclamptic Pregnancies. سامانه مدیریت نشریات علمی, 1383; 2(1): 50-55.

Maternal Serum Levels of Transforming Growth Factor ß1 (TGF-ß1) in Normal and Preeclamptic Pregnancies

Iranian Journal of Immunology
مقاله 6، دوره 2، شماره 1 - شماره پیاپی 4، خرداد 2005، صفحه 50-55    اصل مقاله (37.45 K)
نوع مقاله: Original Article
نویسندگان
Maryam Ayatollahi* 1؛ Alamtaj Samsami Dehaghani2؛ Ziaedin Tabei1
1Transplant Research Center
2OB/GYN Department, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Successful pregnancy in allopregnant women depends upon the control of graft rejection mechanisms. It has been suggested that some immunosuppressive cytokines contribute to successful pregnancy and transplantation. Transforming growth factor beta (TGF-   β) exhibits potent immunoregulatory and anti-inflammatory properties which might prolong graft survival. Recent studies suggest a role for TGF- β   in the generation of T-regulatory lymphocytes which preserves the tolerance to peripheral self antigens and may control the response to allogenic tissues and thereby promote the transplantation tolerance. Also, the function of TGF-   β in trophoblast differentiation and hypertension is reported.  
Objective: To evaluate the maternal serum TGF-   β1 level in normal allopregnant women and in pregnancies complicated by preeclampcia (PE).  
Methods: Sixty one pregnant preeclamptic women (32 cases with severe and 29 with mild PE), 22 normotensive healthy pregnant, and 20 non-pregnant controls constituted the studied groups. The active form of TGF-   β1 in serum from all cases was investigated by indirect ELISA technique.  
Results: The results showed that TGF-   β1 level was higher in all three pregnant groups as compared with the nonpregnant controls. No significant changes in serum levels of TGF-   β1 were found in PE as compared with the normal pregnancy.  
Conclusion: TGF-β1 may function as a regulatory factor in fetal allograft survival during pregnancy, and TGF-   β1 does not have a pathophysiological role in PE.
کلیدواژه‌ها
Fetal Allograft Survival؛ Preeclampsia؛ Transforming Growth Factor-β
آمار
تعداد مشاهده مقاله: 730
تعداد دریافت فایل اصل مقاله: 703


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب