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Ashouri, Elham, Dabbaghmanesh, Mohammad Hossein, Hadaegh, Amirhossein, Rowhanirad, Soodeh, Bakhshayeshkaram, Marizeh, Ranjbar Omrani, Gholamhossein. (1392). KIR Gene Content Does Not Contribute to Susceptibility to Graves’ Disease. سامانه مدیریت نشریات علمی, 10(3), 150-157.
Elham Ashouri; Mohammad Hossein Dabbaghmanesh; Amirhossein Hadaegh; Soodeh Rowhanirad; Marizeh Bakhshayeshkaram; Gholamhossein Ranjbar Omrani. "KIR Gene Content Does Not Contribute to Susceptibility to Graves’ Disease". سامانه مدیریت نشریات علمی, 10, 3, 1392, 150-157.
Ashouri, Elham, Dabbaghmanesh, Mohammad Hossein, Hadaegh, Amirhossein, Rowhanirad, Soodeh, Bakhshayeshkaram, Marizeh, Ranjbar Omrani, Gholamhossein. (1392). 'KIR Gene Content Does Not Contribute to Susceptibility to Graves’ Disease', سامانه مدیریت نشریات علمی, 10(3), pp. 150-157.
Ashouri, Elham, Dabbaghmanesh, Mohammad Hossein, Hadaegh, Amirhossein, Rowhanirad, Soodeh, Bakhshayeshkaram, Marizeh, Ranjbar Omrani, Gholamhossein. KIR Gene Content Does Not Contribute to Susceptibility to Graves’ Disease. سامانه مدیریت نشریات علمی, 1392; 10(3): 150-157.

KIR Gene Content Does Not Contribute to Susceptibility to Graves’ Disease

Iranian Journal of Immunology
مقاله 3، دوره 10، شماره 3، آذر 2013، صفحه 150-157    اصل مقاله (272 K)
نوع مقاله: Original Article
نویسندگان
Elham Ashouri* 1؛ Mohammad Hossein Dabbaghmanesh1؛ Amirhossein Hadaegh2؛ Soodeh Rowhanirad1؛ Marizeh Bakhshayeshkaram1؛ Gholamhossein Ranjbar Omrani1
1Endocrinology and Metabolism Research Center
2Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Killer cell immunoglobulin-like receptors (KIR) are expressed on NK cells and a subset of T cells. The variable KIR receptors along with their ligands, HLA class I, influence risk for autoimmune and malignant diseases.
Objective: To investigate the KIR gene profiles in relation to susceptibility to Graves’ disease in patients with ophthalmopathy.
Methods: KIR genes profiles were analyzed in 90 patients presenting Graves’ disease with ophthalmopathy representing upper eyelid retraction, swelling, redness, conjunctivitis, and bulging eyes and were compared with the KIR gene profiles of 112 healthy controls. The presence and absence of 11 variable KIR genes were characterized using a gene-specific PCR typing system.
Results: There was no significant difference in the distribution of KIR gene profiles between patients and controls.
Conclusion: Our data show that none of the KIR genotypes contribute in susceptibility to Graves’ disease; although the role of HLA ligand remains to be characterized.
کلیدواژه‌ها
Graves’ Disease؛ KIR Gene؛ PCR-SSP
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