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Azimi Mohamadabadi, Maryam, Mohammad Hassan, Zuhair, Hosseini, Ahmad Zavaran, Gholamzad, Mehrdad, Noori, Shekoofe, Mahdavi, Mehdi, Maroof, Hamidreza. (1392). Arteether Exerts Antitumor Activity and Reduces CD4+CD25+FOXP3+ T-reg Cells in Vivo. سامانه مدیریت نشریات علمی, 10(3), 139-149.
Maryam Azimi Mohamadabadi; Zuhair Mohammad Hassan; Ahmad Zavaran Hosseini; Mehrdad Gholamzad; Shekoofe Noori; Mehdi Mahdavi; Hamidreza Maroof. "Arteether Exerts Antitumor Activity and Reduces CD4+CD25+FOXP3+ T-reg Cells in Vivo". سامانه مدیریت نشریات علمی, 10, 3, 1392, 139-149.
Azimi Mohamadabadi, Maryam, Mohammad Hassan, Zuhair, Hosseini, Ahmad Zavaran, Gholamzad, Mehrdad, Noori, Shekoofe, Mahdavi, Mehdi, Maroof, Hamidreza. (1392). 'Arteether Exerts Antitumor Activity and Reduces CD4+CD25+FOXP3+ T-reg Cells in Vivo', سامانه مدیریت نشریات علمی, 10(3), pp. 139-149.
Azimi Mohamadabadi, Maryam, Mohammad Hassan, Zuhair, Hosseini, Ahmad Zavaran, Gholamzad, Mehrdad, Noori, Shekoofe, Mahdavi, Mehdi, Maroof, Hamidreza. Arteether Exerts Antitumor Activity and Reduces CD4+CD25+FOXP3+ T-reg Cells in Vivo. سامانه مدیریت نشریات علمی, 1392; 10(3): 139-149.

Arteether Exerts Antitumor Activity and Reduces CD4+CD25+FOXP3+ T-reg Cells in Vivo

Iranian Journal of Immunology
مقاله 2، دوره 10، شماره 3، آذر 2013، صفحه 139-149    اصل مقاله (606.86 K)
نوع مقاله: Original Article
نویسندگان
Maryam Azimi Mohamadabadi1؛ Zuhair Mohammad Hassan* 1؛ Ahmad Zavaran Hosseini1؛ Mehrdad Gholamzad1؛ Shekoofe Noori2؛ Mehdi Mahdavi3؛ Hamidreza Maroof4
1Department of Immunology, School of Medical Sciences, Tarbiat Modares University
2Department of Biochemistry, School of Medical Sciences, Shahid Beheshti University
3Department of Virology, Pasteur Institute of Iran, Tehran
4Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
چکیده
Background: Chemo-immunotherapy is one of the new achievements for treatment of cancer, by which the success of anti-cancer therapy can be increased. In vitro studies have been shown that Arteether (ARE) induces apoptosis in tumor cells, but not in normal cells.
Objective: To investigate the cytotoxic and immunomodulatory properties of Arteether in-vivo and in-vitro.
Methods: In this study, we used MTT assay for evaluation of cytotoxicity of Arteether on tumor cell line and Peripheral Blood Mononuclear Cells (PBMCs) from healthy individuals. Balb/c mice were subcutaneously transplanted with tumor tissue taken from Spontaneous Mouse Mammary Tumor (SMMT) bearing female mice. Arteether was administered to breast tumor-bearing Balb/c mice at a dose of 6 mg/kg/day intraperitoneally. Tumor sizes, lymphocyte proliferation, cytokines production, and the percentage of splenic T-reg cells were measured.
Results: We observed that ARE could reduce the cell growth of 4T1 cell line in a dose-dependent manner but it had no cytotoxic effect on the growth of peripheral blood lymphocytes. ARE administered intraperitoneally to tumor-bearing Balb/c mice could reduce the tumor growth rate and splenic T-reg cells. No difference in the IFN-γ, IL-10 and IL-4 production was observed between tumor antigenstimulated splenocytes of mice treated with ARE and control mice.
Conclusion: These results underscore antitumor properties of Arteether that may aid in development of more effective antitumor agents.
کلیدواژه‌ها
Arteether؛ Breast cancer؛ immunotherapy
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