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Babaloo, Zohreh, Khajir Yeganeh, Reza, Farhoodi, Mehdi, Baradaran, Behzad, Bonyadi, Mohamadreza, Aghebati, Leila. (1391). Increased IL-17A but Decreased IL-27 Serum Levels in Patients with Multiple Sclerosis. سامانه مدیریت نشریات علمی, 10(1), 47-54.
Zohreh Babaloo; Reza Khajir Yeganeh; Mehdi Farhoodi; Behzad Baradaran; Mohamadreza Bonyadi; Leila Aghebati. "Increased IL-17A but Decreased IL-27 Serum Levels in Patients with Multiple Sclerosis". سامانه مدیریت نشریات علمی, 10, 1, 1391, 47-54.
Babaloo, Zohreh, Khajir Yeganeh, Reza, Farhoodi, Mehdi, Baradaran, Behzad, Bonyadi, Mohamadreza, Aghebati, Leila. (1391). 'Increased IL-17A but Decreased IL-27 Serum Levels in Patients with Multiple Sclerosis', سامانه مدیریت نشریات علمی, 10(1), pp. 47-54.
Babaloo, Zohreh, Khajir Yeganeh, Reza, Farhoodi, Mehdi, Baradaran, Behzad, Bonyadi, Mohamadreza, Aghebati, Leila. Increased IL-17A but Decreased IL-27 Serum Levels in Patients with Multiple Sclerosis. سامانه مدیریت نشریات علمی, 1391; 10(1): 47-54.

Increased IL-17A but Decreased IL-27 Serum Levels in Patients with Multiple Sclerosis

Iranian Journal of Immunology
مقاله 6، دوره 10، شماره 1، خرداد 2013، صفحه 47-54    اصل مقاله (242.1 K)
نوع مقاله: Original Article
نویسندگان
Zohreh Babaloo* 1، 2، 3؛ Reza Khajir Yeganeh1؛ Mehdi Farhoodi2؛ Behzad Baradaran1، 3؛ Mohamadreza Bonyadi1، 3؛ Leila Aghebati1
1Department of Immunology, Faculty of Medicine
2Neuroscience Research Center
3Immunology Unit, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Background: Effector CD4+ T cell subsets play an important role in Multiple Sclerosis (MS). Interleukin-27 (IL-27) suppresses Th (Th1, Th2 and Th17) cells and dampens autoimmunity and tissue inflammation by promoting the generation of Type 1 regulatory T cells (Tr1).
Objective: To identify the relative levels of IL-27 and IL-17A in MS disease.
Method: In a case-control study, venous blood was collected from forty MS patients and forty-three healthy subjects as control group. Serum levels of IL-27 and IL-17A were measured by ELISA method.
Results: A significant difference between serum IL-17A concentration in patients (120.68 ± 209.85 pg/ml) and control group (67.26 ± 117.76 pg/ml, p=0.016) was found. Serum IL-27 levels of the MS patients (159.7 ± 581.4 pg/ml) were significantly lower than control subjects (180.35 ± 507.84 pg/ml, p=0.001).
Conclusion: Our findings show decreased levels of IL-27 against increasing IL-17A levels in patients group which may suggest the suppressive role of IL-27 on inflammatory process of MS.
کلیدواژه‌ها
Interleukin-27؛ Interleukin-17A؛ Multiple Sclerosis
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