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Esmaili, Nafiseh, Mortazavi, Hossein, Chams-Davatchi, Sheyda, Daneshpazhoooh, Maryam, Rayati Damavandi, Maede, Aryanian, Zeinab, Amirzargar, Ali Akbar. (1391). Association between HLA-DQB1*03:01 and Bullous Pemphigoid in Iranian Patients. سامانه مدیریت نشریات علمی, 10(1), 1-9.
Nafiseh Esmaili; Hossein Mortazavi; Sheyda Chams-Davatchi; Maryam Daneshpazhoooh; Maede Rayati Damavandi; Zeinab Aryanian; Ali Akbar Amirzargar. "Association between HLA-DQB1*03:01 and Bullous Pemphigoid in Iranian Patients". سامانه مدیریت نشریات علمی, 10, 1, 1391, 1-9.
Esmaili, Nafiseh, Mortazavi, Hossein, Chams-Davatchi, Sheyda, Daneshpazhoooh, Maryam, Rayati Damavandi, Maede, Aryanian, Zeinab, Amirzargar, Ali Akbar. (1391). 'Association between HLA-DQB1*03:01 and Bullous Pemphigoid in Iranian Patients', سامانه مدیریت نشریات علمی, 10(1), pp. 1-9.
Esmaili, Nafiseh, Mortazavi, Hossein, Chams-Davatchi, Sheyda, Daneshpazhoooh, Maryam, Rayati Damavandi, Maede, Aryanian, Zeinab, Amirzargar, Ali Akbar. Association between HLA-DQB1*03:01 and Bullous Pemphigoid in Iranian Patients. سامانه مدیریت نشریات علمی, 1391; 10(1): 1-9.

Association between HLA-DQB1*03:01 and Bullous Pemphigoid in Iranian Patients

Iranian Journal of Immunology
مقاله 1، دوره 10، شماره 1، خرداد 2013، صفحه 1-9    اصل مقاله (251.57 K)
نوع مقاله: Original Article
نویسندگان
Nafiseh Esmaili1، 2؛ Hossein Mortazavi1، 2؛ Sheyda Chams-Davatchi1، 2؛ Maryam Daneshpazhoooh1، 2؛ Maede Rayati Damavandi1، 2؛ Zeinab Aryanian1، 2؛ Ali Akbar Amirzargar* 3
1Autoimmune Bullous Diseases Research Center
2Department of Dermatology, Razi Hospital
3Molecular Immunology Research Center and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP.
Objective: To investigate the association of HLA class II alleles and haplotypes with BP in Iranian population.
Methods: Fifty patients with Bullous pemphigoid and 180 geographically matched, healthy individuals as control group enrolled into this study. HLA typing of class II (DR and DQ alleles) was carried out using polymerase chain reaction based on sequence-specific primers method.
Results: Class II DQA1 and DQB1 typing showed a significantly higher frequency of HLA-DQA1*05:01 (45% vs. 33%, p=0.03), HLA-DQB1*03:01 (36% vs. 23.6%, p=0.02) and HLA-DQB1*04:01 (4% vs. 1.6%, p=0.04) in the BP patients compared with controls. For DRB1 allele frequencies, there were no significant disease associations. The frequency of DRB1*08:01/DQA1*05:01/DQB1*03:01 (3% vs. 0%, p=0.02) haplotype showed an increase among patients compared with controls.
Conclusion: Our data suggest that Iranian patients with BP present the same genetic predisposition linked to HLA-DQB1*03:01 previously reported in Caucasians.
کلیدواژه‌ها
Bullous Pemphgoid؛ Haplotype؛ HLA Class II Alleles؛ Iranian
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