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Rafinejad, Ali, Niknam, Mohammad Hossein, Amirzargar, Ali Akbar, Khosravi, Farideh, Karimi, Forouzan, Larijani, Bagher. (1383). Association of IFN-¹ Gene Polymorphism with Type 1 Diabetes in Iranian Patients. سامانه مدیریت نشریات علمی, 1(2), 130-132.
Ali Rafinejad; Mohammad Hossein Niknam; Ali Akbar Amirzargar; Farideh Khosravi; Forouzan Karimi; Bagher Larijani. "Association of IFN-¹ Gene Polymorphism with Type 1 Diabetes in Iranian Patients". سامانه مدیریت نشریات علمی, 1, 2, 1383, 130-132.
Rafinejad, Ali, Niknam, Mohammad Hossein, Amirzargar, Ali Akbar, Khosravi, Farideh, Karimi, Forouzan, Larijani, Bagher. (1383). 'Association of IFN-¹ Gene Polymorphism with Type 1 Diabetes in Iranian Patients', سامانه مدیریت نشریات علمی, 1(2), pp. 130-132.
Rafinejad, Ali, Niknam, Mohammad Hossein, Amirzargar, Ali Akbar, Khosravi, Farideh, Karimi, Forouzan, Larijani, Bagher. Association of IFN-¹ Gene Polymorphism with Type 1 Diabetes in Iranian Patients. سامانه مدیریت نشریات علمی, 1383; 1(2): 130-132.

Association of IFN-¹ Gene Polymorphism with Type 1 Diabetes in Iranian Patients

Iranian Journal of Immunology
مقاله 7، دوره 1، شماره 2، آذر 2004، صفحه 130-132    اصل مقاله (135.9 K)
نوع مقاله: Original Article
نویسندگان
Ali Rafinejad1؛ Mohammad Hossein Niknam1؛ Ali Akbar Amirzargar* 1؛ Farideh Khosravi1؛ Forouzan Karimi2؛ Bagher Larijani3
1Department of Immunology, School of Medicine, Tehran University of Medical Sciences
2Iranian National Research Center for Medical Sciences of I.R. IRAN
3Endocrinology and Metabolism Research Center, Tehran, Iran.
چکیده
Background: Type 1 Diabetes (T1D) is a chronic and progressive autoimmune disorder. Cytokines play a critical role in the pathogenesis of T1D.  
Objective: IFN-¹ polymorphism was investigated in T1D and compared with normal controls.  
Methods: Thirty patients suffering from T1D and 40 normal controls were studied simultaneously using PCR technique. IFN-   ¹ gene was evaluated at position 5’UTR +5644.
Results: There was a significant difference between patient and control groups in TT genotype (P<0.05).
Conclusion: In this study, we found a negative association between IFN-¹ gene at position 5’UTR +5644 and T1D in Iranian patients pointing to T allele as a protective factor against T1D.
کلیدواژه‌ها
Cytokine؛ Polymorphism؛ Type 1 Diabetes Mellitus
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