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Eyigor, Mete, Eyigor, Hulya, Osma, Ustun, Yilmaz, MustafaDeniz, Erin, Nuray, Selcuk, Omer Tarik, Sezer, Cem, Gultekin, Meral, Koksoy, Sadi. (1393). Analysis of Serum Cytokine Levels in Larynx Squamous Cell Carcinoma and Dysplasia Patients. سامانه مدیریت نشریات علمی, 11(4), 259-268.
Mete Eyigor; Hulya Eyigor; Ustun Osma; MustafaDeniz Yilmaz; Nuray Erin; Omer Tarik Selcuk; Cem Sezer; Meral Gultekin; Sadi Koksoy. "Analysis of Serum Cytokine Levels in Larynx Squamous Cell Carcinoma and Dysplasia Patients". سامانه مدیریت نشریات علمی, 11, 4, 1393, 259-268.
Eyigor, Mete, Eyigor, Hulya, Osma, Ustun, Yilmaz, MustafaDeniz, Erin, Nuray, Selcuk, Omer Tarik, Sezer, Cem, Gultekin, Meral, Koksoy, Sadi. (1393). 'Analysis of Serum Cytokine Levels in Larynx Squamous Cell Carcinoma and Dysplasia Patients', سامانه مدیریت نشریات علمی, 11(4), pp. 259-268.
Eyigor, Mete, Eyigor, Hulya, Osma, Ustun, Yilmaz, MustafaDeniz, Erin, Nuray, Selcuk, Omer Tarik, Sezer, Cem, Gultekin, Meral, Koksoy, Sadi. Analysis of Serum Cytokine Levels in Larynx Squamous Cell Carcinoma and Dysplasia Patients. سامانه مدیریت نشریات علمی, 1393; 11(4): 259-268.

Analysis of Serum Cytokine Levels in Larynx Squamous Cell Carcinoma and Dysplasia Patients

Iranian Journal of Immunology
مقاله 4، دوره 11، شماره 4، اسفند 2014، صفحه 259-268    اصل مقاله (216.8 K)
نوع مقاله: Original Article
نویسندگان
Mete Eyigor1؛ Hulya Eyigor* 2؛ Ustun Osma2؛ MustafaDeniz Yilmaz2؛ Nuray Erin3؛ Omer Tarik Selcuk2؛ Cem Sezer4؛ Meral Gultekin1؛ Sadi Koksoy1
1Akdeniz University Medical Faculty, Department of Medical Microbiology
2Department of ENT Head and Neck Surgery, Antalya Education and Research Hospital
3Akdeniz University Medical Faculty, Department of Medical Pharmacology
4Department of Pathology, Antalya Education and Research Hospital, Antalya, Turkey
چکیده
Background: Although the imbalance of cytokines in Head and Neck Squamous Cell Carcinoma (HNSCC) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation.
Objective: To determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls.
Methods: Seventeen newly diagnosed, untreated larynx squamous cell carcinoma (SCC) and six laryngeal dysplasia patients as well as 22 healthy controls were analyzed for circulating cytokines. A flowcytometry Th1/Th2 cytokine array kit was used to quantitatively measure Interleukin-2 (IL-2), IL-4, IL-6, IL-10, Tumor Necrosis Factor-α (TNF-α) and Interferon-γ (IFN-γ) levels. Additionally, IL-8 levels were determined through ELISA.
Results: IL-6, IL-8 and IL-10 were determined to be statistically increased in SCC patients (p<0.05). IL-8 and IL-10 levels were also higher in SCC patients than dysplasia patients (p<0.05). Additionally, IL-6 and IL-10 were all found to be markedly increased in dysplasia patients compared with controls (p<0.05).
Conclusion: Our results demonstrate an imbalance of IL-6 and IL-10 not only in HNSCC but also in laryngeal dysplasia.
کلیدواژه‌ها
Bead Array؛ Cytokine؛ Dysplasia؛ HNSCC؛ Larynxm Carcinoma
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