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Malekafzali, Beheshteh, Sattari, Mandana, Keyvanfar, Sanaz. (1393). Correlation between Salivary Toll Like Receptor-2 Concentration and Early Childhood Caries. سامانه مدیریت نشریات علمی, 11(3), 210-216.
Beheshteh Malekafzali; Mandana Sattari; Sanaz Keyvanfar. "Correlation between Salivary Toll Like Receptor-2 Concentration and Early Childhood Caries". سامانه مدیریت نشریات علمی, 11, 3, 1393, 210-216.
Malekafzali, Beheshteh, Sattari, Mandana, Keyvanfar, Sanaz. (1393). 'Correlation between Salivary Toll Like Receptor-2 Concentration and Early Childhood Caries', سامانه مدیریت نشریات علمی, 11(3), pp. 210-216.
Malekafzali, Beheshteh, Sattari, Mandana, Keyvanfar, Sanaz. Correlation between Salivary Toll Like Receptor-2 Concentration and Early Childhood Caries. سامانه مدیریت نشریات علمی, 1393; 11(3): 210-216.

Correlation between Salivary Toll Like Receptor-2 Concentration and Early Childhood Caries

Iranian Journal of Immunology
مقاله 7، دوره 11، شماره 3، آذر 2014، صفحه 210-216    اصل مقاله (81.16 K)
نوع مقاله: Short Paper
نویسندگان
Beheshteh Malekafzali1؛ Mandana Sattari2؛ Sanaz Keyvanfar3
1Dental Research Center, Research Institute of Dental Sciences
2Department of Immunology, School of Medicine
3Department of Pediatric Dentistry, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background: Early childhood caries (ECC) is a common health problem in the developing countries. Basic knowledge about the etiology and pathogenesis of ECC plays an important role in its prevention.
Objective: To determine the relationship between salivary TLR-2 concentration and early childhood caries formation
Methods: Twenty-Eight children with ages ranging from 36 to 71 months (15 in ECC group and 13 in caries free group) were chosen based on inclusion criteria. Their saliva was aspirated in the volumes of 1-2 ml. Resampling was done for 8 subjects of ECC group 3 months after dental restoration. TLR-2 concentration was measured using ELISA.
Results: Mean concentrations of TLR-2 in ECC and caries free group were 2.12 and 1.42 ng/ml, respectively. The difference between concentrations was statistically significant (p=0.008). Three months after treatment in 8 ECC, the mean concentration of TLR-2 (0.925 ng/ml) significantly decreased compared to the original concentration in ECC (p<0.001) and caries free groups (p<0.001).
Conclusion: Elevated concentration of TLR-2 in ECC group compared to caries free group and its decrease after treatment point to the participation of innate immune system and specially TLR-2 in the pathogenesis of early childhood caries.
کلیدواژه‌ها
Early Childhood Caries؛ Saliva؛ TLR-2
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