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Rezvan, Hossein, Khodadadi, Ali, Ali, Selman. (1393). CTL Responses to DCs Stimulated with Leishmania Antigens Detected by DCs Expressing Leishmania gp63. سامانه مدیریت نشریات علمی, 11(2), 65-73.
Hossein Rezvan; Ali Khodadadi; Selman Ali. "CTL Responses to DCs Stimulated with Leishmania Antigens Detected by DCs Expressing Leishmania gp63". سامانه مدیریت نشریات علمی, 11, 2, 1393, 65-73.
Rezvan, Hossein, Khodadadi, Ali, Ali, Selman. (1393). 'CTL Responses to DCs Stimulated with Leishmania Antigens Detected by DCs Expressing Leishmania gp63', سامانه مدیریت نشریات علمی, 11(2), pp. 65-73.
Rezvan, Hossein, Khodadadi, Ali, Ali, Selman. CTL Responses to DCs Stimulated with Leishmania Antigens Detected by DCs Expressing Leishmania gp63. سامانه مدیریت نشریات علمی, 1393; 11(2): 65-73.

CTL Responses to DCs Stimulated with Leishmania Antigens Detected by DCs Expressing Leishmania gp63

Iranian Journal of Immunology
مقاله 1، دوره 11، شماره 2، شهریور 2014، صفحه 65-73    اصل مقاله (426.09 K)
نوع مقاله: Original Article
نویسندگان
Hossein Rezvan* 1؛ Ali Khodadadi2؛ Selman Ali3
1Department of Laboratory Sciences, School of Paraveterinary Sciences, Bu-Ali Sina University, Hamadan
2Department of Immunology, School of Medicine, Jondi Shapour University, Ahwaz, Iran
3School of Science and Technology, Nottingham Trent University, Clifton, Nottingham, UK
چکیده
Background: Leishmania is a pathogenic parasite which infects mononuclear cells in vertebrate hosts. Different strategies have been taken to develop immunity against Leishmania . DCs loaded with immunogenic antigen have resulted in different levels of Th1-type immune response and cytotoxic T lymphocytes (CTL) activity.
Objective: To evaluate the potency of DCs primed with soluble Leishmania mexicana antigens (SLA) in developing CTL activity.
Methods: DCs were loaded with SLA and injected to Balb/c mice. After two weeks the mice were sacrificed and their splenocytes were used as effector cells in a standard 4-hour cytotoxicity assay against DCs transfected with pcDNA3 containing L. mexicana gp63 gene.
Results: Immunization of Balb/c mice with DCs loaded with SLA resulted in high levels of CTL activity against DCs transfected with pcDNA3 containing L. mexicana gp63 gene.
Conclusions: The results indicate a high potency for DCs primed with Leishmania antigens in inducing CTL activity, which can be used for developing an immunogenic vaccine against Leishmania.
کلیدواژه‌ها
Balb/c؛ Cytotoxicity؛ DCs؛ gp63؛ Leishmania
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