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Narain Mishra, Mahendra, Dudeja, Puja, Kumar Gupta, Rakesh. (1392). Association of HLA-Class II and IgE Serum Levels in Pediatric Asthma. سامانه مدیریت نشریات علمی, 11(1), 21-28.
Mahendra Narain Mishra; Puja Dudeja; Rakesh Kumar Gupta. "Association of HLA-Class II and IgE Serum Levels in Pediatric Asthma". سامانه مدیریت نشریات علمی, 11, 1, 1392, 21-28.
Narain Mishra, Mahendra, Dudeja, Puja, Kumar Gupta, Rakesh. (1392). 'Association of HLA-Class II and IgE Serum Levels in Pediatric Asthma', سامانه مدیریت نشریات علمی, 11(1), pp. 21-28.
Narain Mishra, Mahendra, Dudeja, Puja, Kumar Gupta, Rakesh. Association of HLA-Class II and IgE Serum Levels in Pediatric Asthma. سامانه مدیریت نشریات علمی, 1392; 11(1): 21-28.

Association of HLA-Class II and IgE Serum Levels in Pediatric Asthma

Iranian Journal of Immunology
مقاله 3، دوره 11، شماره 1، خرداد 2014، صفحه 21-28    اصل مقاله (208.8 K)
نوع مقاله: Original Article
نویسندگان
Mahendra Narain Mishra* 1؛ Puja Dudeja2؛ Rakesh Kumar Gupta3
1Dr Lal Path Labs, National Reference Laboratory, Rohini, New Delhi
2Department of Preventive and Social Medicine, PGIMER, Chandigarh
3Department of Pediatrics, Armed Forces Medical College, Pune, Maharashtra, India
چکیده
Background: Pediatric bronchial asthma is associated with considerable morbidity. The study was carried out to examine the association of Human Leukocyte Antigen (HLA)- Class II with the disease as we found no similar study on Asian Indian population.
Objective: To define the HLA-Class II antigens in Asian Indian pediatric patients with asthma.
Methods: A total of 103 children with asthma and 152 controls were analysed for HLA Class II (DRB1, DQB1and DPB1) by PCR-SSP (Sequence Specific Primers) method. Total serum IgE levels were determined by ELISA assay.
Results: A positive family history was recorded in 59 patients (57%) and 13 (8.5%) of healthy controls. Serum IgE levels were more than normal range in 72% of the patients and 33% of healthy subjects with mean values of 4877 and 627 IU/ml, respectively. DRB1*04 and DQB1*03 showed significant positive relations while DRB1*15 showed a negative association with asthma. DQB1*02 was more common in healthy individuals but was not statistically significant.
Conclusions: A positive association of the DR4/DQB1*03 and a negative association of DRB1*15 was seen with extrinsic bronchial asthma. However, more studies are required on larger populations to confirm the association of HLA Class II alleles in Indians before a particular allele can be labeled as being protective or causative for asthma.
کلیدواژه‌ها
Asthma؛ Human Leukocyte Antigen Cass II؛ Immunoglobulin E؛ pediatric
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