LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,422,438
تعداد دریافت فایل اصل مقاله11,296,494
Rahmanian, Abdolkarim, Mohebali, Navideh, Haghnegahdar, Ali, Kamali Sarvestani, Eskandar, Razmkon, Ali, Kivelev, Juri, Baghban, Fahim. (1394). Serum Levels of Monocyte Chemoattractant Protein-1 Correlate with Poor Clinical Grades in Cerebral Aneurysms. سامانه مدیریت نشریات علمی, 12(4), 302-310.
Abdolkarim Rahmanian; Navideh Mohebali; Ali Haghnegahdar; Eskandar Kamali Sarvestani; Ali Razmkon; Juri Kivelev; Fahim Baghban. "Serum Levels of Monocyte Chemoattractant Protein-1 Correlate with Poor Clinical Grades in Cerebral Aneurysms". سامانه مدیریت نشریات علمی, 12, 4, 1394, 302-310.
Rahmanian, Abdolkarim, Mohebali, Navideh, Haghnegahdar, Ali, Kamali Sarvestani, Eskandar, Razmkon, Ali, Kivelev, Juri, Baghban, Fahim. (1394). 'Serum Levels of Monocyte Chemoattractant Protein-1 Correlate with Poor Clinical Grades in Cerebral Aneurysms', سامانه مدیریت نشریات علمی, 12(4), pp. 302-310.
Rahmanian, Abdolkarim, Mohebali, Navideh, Haghnegahdar, Ali, Kamali Sarvestani, Eskandar, Razmkon, Ali, Kivelev, Juri, Baghban, Fahim. Serum Levels of Monocyte Chemoattractant Protein-1 Correlate with Poor Clinical Grades in Cerebral Aneurysms. سامانه مدیریت نشریات علمی, 1394; 12(4): 302-310.

Serum Levels of Monocyte Chemoattractant Protein-1 Correlate with Poor Clinical Grades in Cerebral Aneurysms

Iranian Journal of Immunology
مقاله 7، دوره 12، شماره 4، اسفند 2015، صفحه 302-310    اصل مقاله (144.9 K)
نوع مقاله: Original Article
نویسندگان
Abdolkarim Rahmanian1؛ Navideh Mohebali1؛ Ali Haghnegahdar* 1؛ Eskandar Kamali Sarvestani2؛ Ali Razmkon1؛ Juri Kivelev3؛ Fahim Baghban1
1Department of Neurosurgery
2Department of Immunology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Neurosurgery, Helsinki University Central Hospital, Topeliuksenkatu, Finland
چکیده
Background : Ruptured cerebral aneurysms (ICAs) are the most common non-traumatic cause of subarachnoid hemorrhage (SAH) that is associated with life threatening complications such as Vasospasm, Infarction, and Hydrocephalus (HCP). The active participation of macrophage/monocyte-mediated inflammatory response in the pathogenesis of cerebral aneurysm as labeled with Monocyte ChemoattractantProtein-1 (MCP-1) is suggested.
Objective: To measure the serum level of MCP-1 in ruptured CAs in different time intervals .
Methods: We measured the serum levels of MCP-1 in SAH patients who had CAs and compared it with that of MCP-1 in two control groups: including patients with SAH without CAs, and the normal population of blood donors. We also measured the MCP-1 levels in patients with CAs one week afterward to evaluate the effect of treatment. Serum level of MCP-1 was measured by a commercial ELISA assay.
Results: Mean serum MCP-1 level in patients with SAH and CAs was 188.2168 Pg/ml and 331.3982 Pg/ml in the normal population. There was no statistically significant difference between serum levels of MCP-1 on the first (mean=188.2168 Pg/ml) and 7 th days after SAH onset (mean=171.8450 Pg/ml) (p=0.739). Serum level of MCP-1 increased significantly as Glasgow Coma Scale decreased (p=0.078) and Hunt and Hess score increased (p=0.089).
Conclusion: Our results did not show an increasing MCP-1 serum level in patients with aneurysmal SAH. There was a relationship between poor clinical grade and MCP-1 levels in patients with CAs. MCP-1 may be a local inflammatory marker for cerebral aneurysms without systemic manifestation.
کلیدواژه‌ها
Intracranial Aneurysm؛ Level؛ Monocyte Chemoatractic Protein 1؛ serum
آمار
تعداد مشاهده مقاله: 1,479
تعداد دریافت فایل اصل مقاله: 947


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب