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Langroudi, Ladan, Hassan, Zuhair Muhammad, Soleimani, Masoud, Hashemi, Seyed Mahmoud. (1394). Tumor Associated Mesenchymal Stromal Cells Show Higher Immunosuppressive and Angiogenic Properties Compared to Adipose Derived MSCs. سامانه مدیریت نشریات علمی, 12(4), 226-239.
Ladan Langroudi; Zuhair Muhammad Hassan; Masoud Soleimani; Seyed Mahmoud Hashemi. "Tumor Associated Mesenchymal Stromal Cells Show Higher Immunosuppressive and Angiogenic Properties Compared to Adipose Derived MSCs". سامانه مدیریت نشریات علمی, 12, 4, 1394, 226-239.
Langroudi, Ladan, Hassan, Zuhair Muhammad, Soleimani, Masoud, Hashemi, Seyed Mahmoud. (1394). 'Tumor Associated Mesenchymal Stromal Cells Show Higher Immunosuppressive and Angiogenic Properties Compared to Adipose Derived MSCs', سامانه مدیریت نشریات علمی, 12(4), pp. 226-239.
Langroudi, Ladan, Hassan, Zuhair Muhammad, Soleimani, Masoud, Hashemi, Seyed Mahmoud. Tumor Associated Mesenchymal Stromal Cells Show Higher Immunosuppressive and Angiogenic Properties Compared to Adipose Derived MSCs. سامانه مدیریت نشریات علمی, 1394; 12(4): 226-239.

Tumor Associated Mesenchymal Stromal Cells Show Higher Immunosuppressive and Angiogenic Properties Compared to Adipose Derived MSCs

Iranian Journal of Immunology
مقاله 1، دوره 12، شماره 4، اسفند 2015، صفحه 226-239    اصل مقاله (888.67 K)
نوع مقاله: Original Article
نویسندگان
Ladan Langroudi1؛ Zuhair Muhammad Hassan* 1؛ Masoud Soleimani2؛ Seyed Mahmoud Hashemi3
1Department of Immunology
2Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University
3Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background: Differentiation, migratory properties and availability of Mesenchymal Stromal Cells (MSC) have become an important part of biomedical research. However, the functional heterogeneity of cells derived from different tissues has hampered providing definitive phenotypic markers for these cells.
Objective: To characterize and compare the phenotype and cytokines of adipose derived MSCs (AD-MSCs) and tumoral-MSCs (T-MSCs) isolated from mammary tumors of BALB/c mice.
Methods: Immunophenotyping and in vitro differentiation tests were used for MSC characterization. Cytokine and enzyme profiles were assessed using ELISA and Realtime PCR, respectively. Results: T-MSCs expressed significantly higher levels of HLADR (p=0.04). Higher levels of PGE2 and COX-2 enzyme were also observed in TMSCs (p=0.07 and p=0.00, respectively). Additionally, T-MSCs expressed higher levels of iNOS and MMP9 (p=0.01 and p=0.01, respectively). T-MSCs were also able to induce higher levels of proliferation and migration of HUVEC endothelial cells in wound scratch assay compared to AD-MSCs (p=0.015).
Conclusion: Functional differences showed by the surface markers of MSCs, cytokine and enzyme production indicate the effect of different microenvironments on MSCs phenotype and function.
کلیدواژه‌ها
Adipose-Derived Mesenchymal Stromal Cells؛ Breast cancer؛ Immunomodulatory Properties؛ Tumoral-MSCs
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