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Al-Marzook, Tawfik Jasim Mohammad, Mutar Mahdi, Batool, Raouf, Hyam, Zalzala, Haider Hashim, Ali Abid, Laheeb, Nehad, Zena. (1394). The Effect of HLA-DRB1 on Cholecystitis. سامانه مدیریت نشریات علمی, 12(2), 149-155.
Tawfik Jasim Mohammad Al-Marzook; Batool Mutar Mahdi; Hyam Raouf; Haider Hashim Zalzala; Laheeb Ali Abid; Zena Nehad. "The Effect of HLA-DRB1 on Cholecystitis". سامانه مدیریت نشریات علمی, 12, 2, 1394, 149-155.
Al-Marzook, Tawfik Jasim Mohammad, Mutar Mahdi, Batool, Raouf, Hyam, Zalzala, Haider Hashim, Ali Abid, Laheeb, Nehad, Zena. (1394). 'The Effect of HLA-DRB1 on Cholecystitis', سامانه مدیریت نشریات علمی, 12(2), pp. 149-155.
Al-Marzook, Tawfik Jasim Mohammad, Mutar Mahdi, Batool, Raouf, Hyam, Zalzala, Haider Hashim, Ali Abid, Laheeb, Nehad, Zena. The Effect of HLA-DRB1 on Cholecystitis. سامانه مدیریت نشریات علمی, 1394; 12(2): 149-155.

The Effect of HLA-DRB1 on Cholecystitis

Iranian Journal of Immunology
مقاله 7، دوره 12، شماره 2، شهریور 2015، صفحه 149-155    اصل مقاله (119.9 K)
نوع مقاله: Short Paper
نویسندگان
Tawfik Jasim Mohammad Al-Marzook؛ Batool Mutar Mahdi؛ Hyam Raouf؛ Haider Hashim Zalzala؛ Laheeb Ali Abid؛ Zena Nehad
Department of Microbiology, Al-Kindy College of Medicine, Baghdad University, Baghdad, Iraq
چکیده
Background: Cholecystitis is one of the major digestive diseases. Its prevalence is particularly high in some populations. Significant risk factors associated with cholecystitis include age, sex, obesity, diet, parity and type 2 diabetes.
Objective: To determine the association between HLA-DRB1 and cholecystitis.
Methods: This casecontrol study included forty Iraqi Arab patients who had cholecystitis with multiple calculi treated by cholecystectomy admitted in the surgical ward at Al-Kindy Teaching Hospital Baghdad between September -2013 to June -2014. The control group consisted of forty healthy volunteers among the staff of Al-Kindy College of Medicine. Control and cholecystitis patients groups were typed for identifying the DRB1* alleles using DNA-based methodology (PCR-SSOP).
Results: There was an increased frequency of HLA-DRB1*0301 in patients with cholecystitis compared with healthy controls (p=0.0442, odd ratio=4.1111, 95% CI: 1.0372-16.2949).
Conclusion: HLADRB1*0301, as a genetic factor, seems to have an association with cholecystitis.
کلیدواژه‌ها
Cholecystitis؛ Molecular؛ Genetic
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