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Childhood Autoimmune Hepatitis in Bahrain: a Tertiary Center Experience | ||
| Iranian Journal of Immunology | ||
| مقاله 6، دوره 12، شماره 2، شهریور 2015، صفحه 141-148 اصل مقاله (426.24 K) | ||
| نوع مقاله: Case Series | ||
| نویسندگان | ||
| Eman Farid* ؛ Hasan M Isa؛ Mohamed Al Nasef؛ Rawia Mohamed؛ Huda Jamsheer | ||
| Department of Pathology, Salmaniya Medical Complex, Manama-Kingdom, Bahrain | ||
| چکیده | ||
| Background: Autoimmune hepatitis (AIH) in childhood has variable modes of presentation, and the disease should be suspected and excluded in all children presenting with symptoms and signs of prolonged or severe acute liver disease. In AIH, the liver biopsy histopathology shows inflammation in addition to presence of serum autoimmune antibodies and increased levels of immunoglobulin G (IgG). Objectives: To investigate the situation of childhood autoimmune hepatitis in Bahrain and to compare it with other studies worldwide. Methods: A retrospective study describing the AIH pediatric cases diagnosed during the period of Jan 2005 to Dec 2009. We report the clinical, biochemical, histopathological, and immunological findings, mainly autoimmune profile, in addition to response to treatment, of Bahraini children with autoimmune hepatitis. Results: Five Bahraini children, three females and two males were diagnosed as autoimmune hepatitis during the study period. Their ages at presentation ranged from 9 to 15 (median 10.6) years. One of our patients had a fulminating type. Two had other autoimmune related conditions, namely autoimmune sclerosing cholangitis and ulcerative colitis. All were AIH type 1. Variable response to conventional immunosuppressive therapy was found, from an excellent response with good prognosis, to cirrhosis, hepatic failure and liver transplantation. Conclusion: Childhood AIH is a rare medical problem in Bahrain, with both sexes affected and a variable response to immunosuppressive therapy. | ||
| کلیدواژهها | ||
| Autoimmune Hepatitis؛ Bahrain؛ children | ||
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آمار تعداد مشاهده مقاله: 945 تعداد دریافت فایل اصل مقاله: 1,008 |
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