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Bargostavan, Mohammad Hasan, Eslami, Gilda, Esfandiari, Nasrin, Shahemabadi, Ali Shams. (1394). MMP9 Promoter Polymorphism (-1562 C/T) Does not Affect the Serum Levels of Soluble MICB and MICA in Breast Cancer. سامانه مدیریت نشریات علمی, 13(1), 45-53.
Mohammad Hasan Bargostavan; Gilda Eslami; Nasrin Esfandiari; Ali Shams Shahemabadi. "MMP9 Promoter Polymorphism (-1562 C/T) Does not Affect the Serum Levels of Soluble MICB and MICA in Breast Cancer". سامانه مدیریت نشریات علمی, 13, 1, 1394, 45-53.
Bargostavan, Mohammad Hasan, Eslami, Gilda, Esfandiari, Nasrin, Shahemabadi, Ali Shams. (1394). 'MMP9 Promoter Polymorphism (-1562 C/T) Does not Affect the Serum Levels of Soluble MICB and MICA in Breast Cancer', سامانه مدیریت نشریات علمی, 13(1), pp. 45-53.
Bargostavan, Mohammad Hasan, Eslami, Gilda, Esfandiari, Nasrin, Shahemabadi, Ali Shams. MMP9 Promoter Polymorphism (-1562 C/T) Does not Affect the Serum Levels of Soluble MICB and MICA in Breast Cancer. سامانه مدیریت نشریات علمی, 1394; 13(1): 45-53.

MMP9 Promoter Polymorphism (-1562 C/T) Does not Affect the Serum Levels of Soluble MICB and MICA in Breast Cancer

Iranian Journal of Immunology
مقاله 6، دوره 13، شماره 1، خرداد 2016، صفحه 45-53    اصل مقاله (260 K)
نوع مقاله: Original Article
نویسندگان
Mohammad Hasan Bargostavan1؛ Gilda Eslami2؛ Nasrin Esfandiari3؛ Ali Shams Shahemabadi* 4
1Department of Immunology, International Campus
2Department of Parasitology, Faculty of Medicine
3Immam Ali Clinic
4Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
چکیده
Background: The role of Matrix Metalloproteinase 9 (MMP9) in tumor invasion and progression is prominent. A single nucleotide polymorphism (SNP) in the promoter region of MMP9 (-1562 C/T) increases the transcription and expression of this gene. On the other hand, MHC class I chain-related protein A and B (MICA/B) in soluble forms may impair tumor immunogenicity by reducing Natural Killer Group 2D (NKG2D) densities on NK cells and MMP9 enzyme activity has a prominent role in shedding of MICA/B.
Objectives: To investigate the association between MMP9 (-1562 C/T) polymorphism and serum MICA/B level in breast cancer patients.
Methods: In this case-control study, 105 patients with breast cancer and 100 healthy age-matched women were selected from Yazd hospitals, Iran. The polymorphism of MMP9 (-1562 C/T) was determined by PCR-RFLP. Concentration of MICB and MICA in the sera of breast cancer patients and healthy women were measured using ELISA method.
Results: The frequency of CC, CT and TT genotypes and T allele of the MMP9 (-1562 C/T) did not show significant differences between breast cancer patients and healthy donors (p>0.05). On the other hand, the mean serum levels of MICB and MICA were significantly elevated in patients compared with healthy individuals (p<0.05). In patients with MMP9CC genotype, the mean serum MICB concentration was significantly higher than those patients with CT polymorphism (p<0.05). Although the mean of blood MICA concentration in patients with the CT genotype was higher than those patients with CC genotype, the difference was not statistically significant.
Conclusion: The T allele of the MMP9 (-1562 C/T) does not show a correlation with serum levels of MICA and MICB in breast cancer patients.
کلیدواژه‌ها
Breast cancer؛ Matrix Metalloproteinase 9؛ MHC Class I-Related Chain A
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