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Khademi, Bijan, Tajvarpour, Marziyeh, Mojtahedi, Zahra, Haghshenas, Mohammad Reza, Erfani, Nasrollah. (1394). T-helper Type 1 and 2 Cytokine Levels in Patients with Benign and Malignant Salivary Gland Tumors. سامانه مدیریت نشریات علمی, 13(1), 9-15.
Bijan Khademi; Marziyeh Tajvarpour; Zahra Mojtahedi; Mohammad Reza Haghshenas; Nasrollah Erfani. "T-helper Type 1 and 2 Cytokine Levels in Patients with Benign and Malignant Salivary Gland Tumors". سامانه مدیریت نشریات علمی, 13, 1, 1394, 9-15.
Khademi, Bijan, Tajvarpour, Marziyeh, Mojtahedi, Zahra, Haghshenas, Mohammad Reza, Erfani, Nasrollah. (1394). 'T-helper Type 1 and 2 Cytokine Levels in Patients with Benign and Malignant Salivary Gland Tumors', سامانه مدیریت نشریات علمی, 13(1), pp. 9-15.
Khademi, Bijan, Tajvarpour, Marziyeh, Mojtahedi, Zahra, Haghshenas, Mohammad Reza, Erfani, Nasrollah. T-helper Type 1 and 2 Cytokine Levels in Patients with Benign and Malignant Salivary Gland Tumors. سامانه مدیریت نشریات علمی, 1394; 13(1): 9-15.

T-helper Type 1 and 2 Cytokine Levels in Patients with Benign and Malignant Salivary Gland Tumors

Iranian Journal of Immunology
مقاله 2، دوره 13، شماره 1، خرداد 2016، صفحه 9-15    اصل مقاله (153.82 K)
نوع مقاله: Original Article
نویسندگان
Bijan Khademi1، 2؛ Marziyeh Tajvarpour1؛ Zahra Mojtahedi1؛ Mohammad Reza Haghshenas1؛ Nasrollah Erfani* 1
1Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine
2Department of Otolaryngology, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Salivary gland tumors are among malignancies that have high recurrence rate. Immune responses in salivary gland tumors have not been well elucidated. T helper type 1 (Th1) and Th2 cytokines have been reported to play a role in the outcome of head and neck cancers.
Objective: To evaluate the serum levels of interferon gamma (IFN- γ), as the hallmark of Th1 cytokines, and interleukin-4 (IL-4), as the hallmark of Th2 cytokines, in patients with benign and malignant salivary gland tumors in comparison with healthy controls.
Methods: Fifty patients with benign and 14 patients with malignant salivary gland tumors, as well as 23 healthy individuals were recruited. Serum levels of IFN-γ and IL-4 were measured using ELISA method. Nonparametric tests were used for data analysis.
Results: Serum levels of IFN-γ and IL-4 were found not to be significantly different in patients compared to the control group (0.68 ± 0.29 vs. 1.03 ± 0.57 pg/ml, p=0.58 for IFN-γ, 4.57 ± 1.57 vs. 4.41 ± 1.31 pg/ml, p=0.28 for IL-4). IFN-γ and IL-4 serum levels were also not significantly different between patients with benign and malignant salivary gland tumors (p=0.54 and p=0.86, respectively).
Conclusion: The systemic levels of IL-4 and IFN-γ seem not to be associated with salivary gland tumor in our study. Investigation of other cytokines produced by Th1 and Th2 cells are warranted.
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