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Sajedi Khania, Mahdi, Abdi Ardekan, Alireza, Khosropana, Shahdad, Doroudchi, Mehrnoosh. (1395). Correlation of Early and Late Ejection Fractions with CCL5 and CCL18 Levels in Acute Anterior Myocardial Infarction. سامانه مدیریت نشریات علمی, 13(2), 100-113.
Mahdi Sajedi Khania; Alireza Abdi Ardekan; Shahdad Khosropana; Mehrnoosh Doroudchi. "Correlation of Early and Late Ejection Fractions with CCL5 and CCL18 Levels in Acute Anterior Myocardial Infarction". سامانه مدیریت نشریات علمی, 13, 2, 1395, 100-113.
Sajedi Khania, Mahdi, Abdi Ardekan, Alireza, Khosropana, Shahdad, Doroudchi, Mehrnoosh. (1395). 'Correlation of Early and Late Ejection Fractions with CCL5 and CCL18 Levels in Acute Anterior Myocardial Infarction', سامانه مدیریت نشریات علمی, 13(2), pp. 100-113.
Sajedi Khania, Mahdi, Abdi Ardekan, Alireza, Khosropana, Shahdad, Doroudchi, Mehrnoosh. Correlation of Early and Late Ejection Fractions with CCL5 and CCL18 Levels in Acute Anterior Myocardial Infarction. سامانه مدیریت نشریات علمی, 1395; 13(2): 100-113.

Correlation of Early and Late Ejection Fractions with CCL5 and CCL18 Levels in Acute Anterior Myocardial Infarction

Iranian Journal of Immunology
مقاله 3، دوره 13، شماره 2، شهریور 2016، صفحه 100-113    اصل مقاله (1.23 M)
نوع مقاله: Original Article
نویسندگان
Mahdi Sajedi Khania1؛ Alireza Abdi Ardekan1؛ Shahdad Khosropana1؛ Mehrnoosh Doroudchi* 2
1Department of Cardiology,Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Acute Myocardial Infarction (AMI) is the leading cause of disability and death in Iran and many other countries.
Objective: To investigate the prognostic value of CCL5 and CCL18 in patients with acute myocardial ischemia. Methods: In this cohort study we recruited and followed 50 patients with acute anterior myocardial infarction (AAMI) for developing cardiovascular accidents in a 6-month period. CCL5 and CCL18 levels were measured on admission, at day 5 and at day 180 posthospitalization.
Results: CCL18 and CCL5 levels at day 180 were higher in patients with late (day 180) and early (day 5) LVEF less than 35% compared to those with higher LVEF (p=0.05 and p=0.042, respectively). There was a negative correlation between early and late LVEF and regional wall motion abnormalities (p=0.001 and p=0.002, respectively). There was also a trend of negative correlation between CCL18 levels at day 5 and LVEF levels at day 180 post-hospitalization (p=0.06).
Conclusion: CCL18 has a correlation with cardiac function in patients with AAMI and it might be considered as an indicator of poor LVEF in patients with AAMI.
کلیدواژه‌ها
Acute Anterior Myocardial Infarction؛ CCL5؛ CCL18؛ Ejection fraction
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