LinkedIn

 آمار

تعداد نشریات21
تعداد شماره‌ها1,303
تعداد مقالات11,915
تعداد مشاهده مقاله83,446,300
تعداد دریافت فایل اصل مقاله122,168,090
Xiao, Zhiya, Hu, Jun. (1406). HO-3867 Induces Cell Apoptosis by Reducing STAT3 Signaling in Hepatocellular Carcinoma. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2026.107082.2282
Zhiya Xiao; Jun Hu. "HO-3867 Induces Cell Apoptosis by Reducing STAT3 Signaling in Hepatocellular Carcinoma". سامانه مدیریت نشریات علمی, , , 1406, -. doi: 10.30476/mejc.2026.107082.2282
Xiao, Zhiya, Hu, Jun. (1406). 'HO-3867 Induces Cell Apoptosis by Reducing STAT3 Signaling in Hepatocellular Carcinoma', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2026.107082.2282
Xiao, Zhiya, Hu, Jun. HO-3867 Induces Cell Apoptosis by Reducing STAT3 Signaling in Hepatocellular Carcinoma. سامانه مدیریت نشریات علمی, 1406; (): -. doi: 10.30476/mejc.2026.107082.2282

HO-3867 Induces Cell Apoptosis by Reducing STAT3 Signaling in Hepatocellular Carcinoma

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 فروردین 1406    اصل مقاله (593.96 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2026.107082.2282
نویسندگان
Zhiya Xiao؛ Jun Hu*
Hunan Aerospace Hospital, ChangSha, China
چکیده
Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with limited treatment options. HO-3867, a STAT3 inhibitor, has shown anticancer effects in other malignancies, but its role in HCC remains unclear. This study aimed to investigate the efficacy and mechanism of HO-3867 against HCC.
Method: We conducted an experimental study combining in-vitro cell assays (proliferation, colony formation, apoptosis analysis, Western blot) using HCC cell lines and in-vivo nude mouse xenograft model, and all quantitative experimental data were statistically analyzed using unpaired two-tailed Student's t-test for comparisons between two groups and one-way analysis of variance (ANOVA) followed by Tukey's post-hoc test for multiple group comparisons, with a P-value less than 0.05 defined as statistically significant.
Results: HO-3867 significantly inhibited HCC cell viability, colony formation, and induced apoptosis in-vitro, and suppressed tumor growth in-vivo via inhibiting STAT3 phosphorylation and downstream anti-apoptotic protein expression.
Conclusion: HO-3867 exerts potent anti-HCC effects through targeting STAT3 signaling, providing a preclinical basis for further clinical development.
کلیدواژه‌ها
Hepatocellular carcinoma؛ HO-3867؛ STAT3؛ Apoptosis
مراجع
  1. Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A, Roberts LR. A global view of hepatocellular carcinoma: trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol. 2019;16(10):589-604. doi: 10.1038/s41575-019-0186-y. PMID: 31439937; PMCID: PMC6813818.
  2. Koshy A. Evolving global etiology of hepatocellular carcinoma (HCC): Insights and trends for 2024. J Clin Exp Hepatol. 2025;15(1):102406. doi: 10.1016/j.jceh.2024.102406. PMID: 39346785; PMCID: PMC11426038.
  3. Piñero F, Dirchwolf M, Pessôa MG. Biomarkers in hepatocellular carcinoma: Diagnosis, prognosis and treatment response assessment. Cells. 2020;9(6):1370. doi: 10.3390/cells9061370. PMID: 32492896; PMCID: PMC7349517.
  4. Bao MH, Wong CC. Hypoxia, metabolic reprogramming, and drug resistance in liver cancer. Cells. 2021;10(7):1715. doi: 10.3390/cells10071715. PMID: 34359884; PMCID: PMC8304710.
  5. Liu W, Zhang F, Quan B, Yao F, Chen R, Ren Z, et al. DDR2/STAT3 positive feedback loop mediates the immunosuppressive microenvironment by upregulating PD-L1 and recruiting MDSCs in oxaliplatin-resistant HCC. Cell Mol Gastroenterol Hepatol. 2024;18(4):101377. doi: 10.1016/j.jcmgh.2024.101377. PMID: 38969205; PMCID: PMC11386308.
  6. Dong S, Guo X, Han F, He Z, Wang Y. Emerging role of natural products in cancer immunotherapy. Acta Pharm Sin B. 2022;12(3):1163-85. doi: 10.1016/j.apsb.2021.08.020. PMID: 35530162; PMCID: PMC9069318.
  7. Naik A, Thomas R, Sikhondze M, Babiker A, Lattab B, Qasem H, et al. The LDHC-STAT3 signaling network is a key regulator of basal-like breast cancer cell survival. Cancers (Basel). 2024;16(13):2451. doi: 10.3390/cancers16132451. PMID: 39001513; PMCID: PMC11240808.
  8. Tong L, Li J, Li Q, Wang X, Medikonda R, Zhao T, et al. ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma. Theranostics. 2020;10(13):5943-56. doi: 10.7150/thno.41498. PMID: 32483429; PMCID: PMC7254983.
  9. Ahmad N, Chen L, Yuan Z, Ma X, Yang X, Wang Y, et al. Pyrimidine compounds BY4003 and BY4008 inhibit glioblastoma cells growth via modulating JAK3/STAT3 signaling pathway. Neurotherapeutics. 2024;21(5):e00431. doi: 10.1016/j.neurot.2024.e00431. PMID: 39153914; PMCID: PMC11579875.
  10. Mast JM, Tse D, Shee K, Lakshmi Kuppusamy M, Kmiec MM, Kálai T, et al. Diarylidenylpiperidones, H-4073 and HO-3867, induce G2/M cell-cycle arrest, apoptosis and inhibit STAT3 phosphorylation in human pancreatic cancer cells. Cell Biochem Biophys. 2019;77(2):109-19. doi: 10.1007/s12013-019-00873-6. PMID: 31089934.
  11. Rath KS, Naidu SK, Lata P, Bid HK, Rivera BK, McCann GA, et al. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res. 2014;74(8):2316-27. doi: 10.1158/0008-5472.CAN-13-2433. PMID: 24590057; PMCID: PMC4286190.
  12. Devor EJ, Schickling BM, Lapierre JR, Bender DP, Gonzalez-Bosquet J, Leslie KK. The synthetic curcumin analog HO-3867 rescues suppression of PLAC1 expression in ovarian cancer cells. Pharmaceuticals (Basel). 2021;14(9):942. doi: 10.3390/ph14090942. PMID: 34577642; PMCID: PMC8465575.
  13. Chen CW, Hsieh MJ, Ju PC, Hsieh YH, Su CW, Chen YL, et al. Curcumin analog HO-3867 triggers apoptotic pathways through activating JNK1/2 signalling in human oral squamous cell carcinoma cells. J Cell Mol Med. 2022;26(8):2273-84. doi: 10.1111/jcmm.17248. PMID: 35191177; PMCID: PMC8995445.
  14. Hu Y, Zhao C, Zheng H, Lu K, Shi D, Liu Z, et al. A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. Anticancer Drugs. 2017;28(4):392-400. doi: 10.1097/CAD.0000000000000470. PMID: 28067673.
  15. Sanaei M, Kavoosi F. Effect of valproic acid on the class I histone deacetylase 1, 2 and 3, tumor suppressor genes p21WAF1/CIP1 and p53, and intrinsic mitochondrial apoptotic pathway, pro- (Bax, Bak, and Bim) and anti- (Bcl-2, Bcl-xL, and Mcl-1) apoptotic genes expression, cell viability, and apoptosis induction in hepatocellular carcinoma HepG2 cell line. Asian Pac J Cancer Prev. 2021;22(S1):89-95. doi: 10.31557/APJCP.2021.22.S1.89. PMID: 33576217.
  16. Sakaue T, Dorayappan KDP, Zingarelli R, Khadraoui W, Anbalagan M, Wallbillich J, et al. Obesity-induced extracellular vesicles proteins drive the endometrial cancer pathogenesis: therapeutic potential of HO-3867 and metformin. Oncogene. 2024;43(49):3586-97. doi: 10.1038/s41388-024-03182-2. Erratum in: Oncogene. 2026;45(34):3623-6. doi: 10.1038/s41388-026-03949-9. PMID: 39414985; PMCID: PMC11602708.
  17. Naeem A, Hu P, Yang M, Zhang J, Liu Y, Zhu W, et al. Natural products as anticancer agents: Current status and future perspectives. Molecules. 2022;27(23):8367. doi: 10.3390/molecules27238367. PMID: 36500466; PMCID: PMC9737905.
  18. Hsueh K, Ju P, Hsieh Y, Su S, Yeh C, Lin C, et al. HO-3867, a curcumin analog, elicits cell apoptosis and p38-mediated caspase activation in hepatocellular carcinoma. Environ Toxicol. 2024;39(2):794-802. doi: 10.1002/tox.23987. PMID: 37997413.
  19. Devor E J, Schickling B M, Lapierre J R, Bender D P, Gonzalez-Bosquet J, Leslie K K, et al. The Synthetic Curcumin Analog HO-3867 Rescues Suppression of PLAC1 Expression in Ovarian Cancer Cells. Pharmaceuticals (Basel). 2021;14(9):942. doi: 10.3390/pharmaceuticals14090942. PMID: 34577566; PMCID: PMC8465827.
  20. Das A, Kamran M, Ali N, et al. HO-3867 Induces ROS-Dependent Stress Response and Apoptotic Cell Death in Leishmania donovani. Front Cell Infect Microbiol. 2021;11:774899. doi: 10.3389/fcimb.2021.774899. PMID: 34976765; PMCID: PMC8718789.
آمار
تعداد مشاهده مقاله: 2
تعداد دریافت فایل اصل مقاله: 2


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب