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Yazdan nasab, Narges, Hormati Oughoulbaig, Amir, Asadi, Asadollah, Parandak, Seyedeh Zeinab. (1405). The Effect of Ginseng and Ginseng-Containing Supplements on Fatigue: A Systematic Review and Meta-Analysis. سامانه مدیریت نشریات علمی, 11(3), 417-426. doi: 10.30476/ijns.2026.108887.1577
Narges Yazdan nasab; Amir Hossein Hormati Oughoulbaig; Asadollah Asadi; Seyedeh Zeinab Parandak. "The Effect of Ginseng and Ginseng-Containing Supplements on Fatigue: A Systematic Review and Meta-Analysis". سامانه مدیریت نشریات علمی, 11, 3, 1405, 417-426. doi: 10.30476/ijns.2026.108887.1577
Yazdan nasab, Narges, Hormati Oughoulbaig, Amir, Asadi, Asadollah, Parandak, Seyedeh Zeinab. (1405). 'The Effect of Ginseng and Ginseng-Containing Supplements on Fatigue: A Systematic Review and Meta-Analysis', سامانه مدیریت نشریات علمی, 11(3), pp. 417-426. doi: 10.30476/ijns.2026.108887.1577
Yazdan nasab, Narges, Hormati Oughoulbaig, Amir, Asadi, Asadollah, Parandak, Seyedeh Zeinab. The Effect of Ginseng and Ginseng-Containing Supplements on Fatigue: A Systematic Review and Meta-Analysis. سامانه مدیریت نشریات علمی, 1405; 11(3): 417-426. doi: 10.30476/ijns.2026.108887.1577

The Effect of Ginseng and Ginseng-Containing Supplements on Fatigue: A Systematic Review and Meta-Analysis

International Journal of Nutrition Sciences
مقاله 3، دوره 11، شماره 3، آذر 2026، صفحه 417-426    اصل مقاله (1.95 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijns.2026.108887.1577
نویسندگان
Narges Yazdan nasab1؛ Amir Hossein Hormati Oughoulbaig2؛ Asadollah Asadi* 1؛ Seyedeh Zeinab Parandak2
1Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
2Department of Sport Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
چکیده
Background: Ginseng is widely used as an adaptogen to reduce fatigue, but evidence for its efficacy, as measured by the Visual Analog Scale (VAS), remains inconsistent. This systematic review and meta-analysis aimed to evaluate the effects of ginseng and ginseng-containing supplements on fatigue severity measured by VAS.
Methods: A comprehensive literature search was conducted in PubMed/Medline, Scopus, Google Scholar, WHO ICTRP, and ClinicalTrials.gov up to July 2025. Randomized controlled trials (RCTs) investigating the effect of Panax ginseng on VAS-measured fatigue were included. Data extraction and risk of bias assessment were performed independently by two reviewers. Statistical analysis was conducted using Stata 15, with a random-effects model to estimate pooled mean differences (MDs) and 95% confidence intervals (CIs). Heterogeneity was assessed using I² and Cochran’s Q statistics. Subgroup analysis was performed based on intervention duration.
Results: The pooled results showed a significant reduction in VAS fatigue scores in the ginseng group compared to placebo (MD=1.28, 95%CI: 0.69 to 1.87, p<0.001) and a substantial heterogeneity was observed (I²=89.3%, p<0.001). Subgroup analysis revealed significant improvements after 2–4 weeks of intervention (MD=1.65–1.80), while longer durations (8–12 weeks) showed no significant effects. Sensitivity analysis confirmed the robustness of the results, and no significant publication bias was detected.
Conclusion: Ginseng supplementation significantly reduced fatigue within short-term interventions (2–4 weeks), supporting its role as a natural adaptogen for fatigue management. However, high heterogeneity among studies highlights the need for further well-designed trials with standardized protocols.

تازه های تحقیق

Narges Yazdan nasab (Google Scholar)

Asadollah Asadi (Google Scholar)

کلیدواژه‌ها
Panax ginseng؛ Fatigue؛ Visual Analog Scale؛ Herbal medicine
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