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Colitis Cystica Profunda: A Benign Deceiver in the Era of Advanced Imaging | ||
| Iranian Journal of Colorectal Research | ||
| دوره 14، شماره 1، خرداد 2026 اصل مقاله (3.33 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.30476/acrr.2026.110491.1282 | ||
| نویسنده | ||
| Sajad Ahmad Salati* | ||
| Department of Surgery, College of Medicine, Qassim University, KSA | ||
| چکیده | ||
| Colitis cystica profunda (CCP) is a rare, benign colorectal disorder characterized by mucin-filled cysts located within the submucosa. Despite its non-neoplastic nature, CCP frequently mimics mucinous adenocarcinoma clinically, endoscopically, radiologically, and histologically, posing a significant diagnostic challenge that can lead to unnecessary radical surgery. This review synthesizes evidence from searches of PubMed, Embase, and Google Scholar up to December 2025 to provide a contemporary overview of the etiopathogenesis, diagnostic challenges, differential diagnosis, and management of CCP. Accurate diagnosis relies on demonstrating the submucosal location of mucin-filled cysts and excluding invasive malignancy through a multimodal assessment. Endoscopic ultrasonography and magnetic resonance imaging assist in defining lesion depth and maintaining diagnostic confidence, while histopathological identification of a specialized lamina propria rim surrounding displaced glands helps distinguish CCP from invasive adenocarcinoma. Current management emphasizes correcting underlying mechanical factors, such as rectal prolapse and chronic straining, rather than routine radical resection. Recognizing the characteristic features of CCP is essential to avoid misdiagnosis and to support evidence-based, organ-preserving management. | ||
تازه های تحقیق | ||
Sajad Ahmad Salati (Google Scholar) | ||
| کلیدواژهها | ||
| Colorectal Neoplasms؛ Colitis؛ Adenocarcinoma, Mucinous؛ Diagnosis, Differential | ||
| مراجع | ||
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