LinkedIn

 آمار

تعداد نشریات21
تعداد شماره‌ها1,297
تعداد مقالات11,876
تعداد مشاهده مقاله83,322,772
تعداد دریافت فایل اصل مقاله122,066,138
Elyasi, Mahshid, Bagherniya, Mohammad, Alikiaii, Babak, Zare, Morteza, Ahmadi, Afsane, Reisinejad, Zahra, Shokri, Shiva, Eftekhari, Mohammad Hassan. (1405). Effects of Synbiotic Supplementation on Biochemical, Coagulation, and Hematological Parameters in Intensive Care Unit Patients with Multiple Trauma and Traumatic Brain Injury. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijns.2026.112320.1709
Mahshid Elyasi; Mohammad Bagherniya; Babak Alikiaii; Morteza Zare; Afsane Ahmadi; Zahra Reisinejad; Shiva Shokri; Mohammad Hassan Eftekhari. "Effects of Synbiotic Supplementation on Biochemical, Coagulation, and Hematological Parameters in Intensive Care Unit Patients with Multiple Trauma and Traumatic Brain Injury". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/ijns.2026.112320.1709
Elyasi, Mahshid, Bagherniya, Mohammad, Alikiaii, Babak, Zare, Morteza, Ahmadi, Afsane, Reisinejad, Zahra, Shokri, Shiva, Eftekhari, Mohammad Hassan. (1405). 'Effects of Synbiotic Supplementation on Biochemical, Coagulation, and Hematological Parameters in Intensive Care Unit Patients with Multiple Trauma and Traumatic Brain Injury', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijns.2026.112320.1709
Elyasi, Mahshid, Bagherniya, Mohammad, Alikiaii, Babak, Zare, Morteza, Ahmadi, Afsane, Reisinejad, Zahra, Shokri, Shiva, Eftekhari, Mohammad Hassan. Effects of Synbiotic Supplementation on Biochemical, Coagulation, and Hematological Parameters in Intensive Care Unit Patients with Multiple Trauma and Traumatic Brain Injury. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/ijns.2026.112320.1709

Effects of Synbiotic Supplementation on Biochemical, Coagulation, and Hematological Parameters in Intensive Care Unit Patients with Multiple Trauma and Traumatic Brain Injury

International Journal of Nutrition Sciences
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 20 شهریور 1405    اصل مقاله (636.69 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/ijns.2026.112320.1709
نویسندگان
Mahshid Elyasi1؛ Mohammad Bagherniya2؛ Babak Alikiaii3؛ Morteza Zare4؛ Afsane Ahmadi5؛ Zahra Reisinejad3؛ Shiva Shokri1؛ Mohammad Hassan Eftekhari* 5
1Student Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
3Department of Anesthesiology, School of Medicine, Anesthesiology and Critical Care Research Center, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
4Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Synbiotic supplementation may support gastrointestinal and systemic homeostasis among intensive care unit (ICU) patients. This study evaluated the effects of short-term synbiotic supplementation on biochemical, renal, hepatic, coagulation, electrolyte, and hematological parameters in ICU-admitted patients with traumatic brain injury (TBI).
Methods: This double-blind, placebo-controlled randomized clinical trial enrolled 62 ICU patients with TBI (Glasgow Coma Scale 4-14) at Al-Zahra Medical Sciences Hospital, Isfahan, from December 2024 to June 2025. Participants were randomized 1:1 to receive synbiotics (3.6×109 CFU/day probiotics plus inulin, 20 g/day) or placebo (maltodextrin) via gavage for 1 week. Blood samples were collected at baseline and post-intervention to assess biochemical, electrolyte, coagulation, and hematological parameters.
Results: No significant between-group differences were observed in parameters, including fasting blood sugar, blood urea nitrogen, liver enzymes, coagulation indices, electrolytes, and blood cell counts. However, synbiotic supplementation led to significant within-group reductions in serum creatinine (p=0.001), sodium (p=0.002), and chloride (p<0.001), as well as neutrophil percentage (p=0.038), and a significant increase in platelet count (p=0.002).
Conclusion: Short-term synbiotic supplementation was associated with significant within-group improvements in laboratory parameters. However, between-group differences were not statistically significant, suggesting that larger and longer studies are needed to establish clinical relevance.

تازه های تحقیق

Mahshid Elyasi (Google Scholar)

Mohammad Hassan Eftekhari (Google Scholar)

کلیدواژه‌ها
Traumatic brain injury؛ Synbiotics؛ Intensive care unit؛ Liver function tests؛ Electrolytes
مراجع
  1. Blennow K, Brody DL, Kochanek PM, Levin H, McKee A, Ribbers GM, et al. Traumatic brain injuries. Nat Rev Dis Primers. 2016;2:16084. DOI: 10.1038/nrdp.2016.84. PMID: 27853132.
  2. Corrigan JD, Selassie AW, Orman JAL. The epidemiology of traumatic brain injury. J Head Trauma Rehabil. 2010;25:72-80. DOI: 10.1097/HTR.0b013e3181ccc8b4. PMID: 20234226.
  3. Ghajar J. Traumatic brain injury. Lancet. 2000;356:923-9. DOI: 10.1016/S0140-6736(00)02689-1. PMID: 11036909.
  4. Risdall JE, Menon DK. Traumatic brain injury. Philos Trans R Soc Lond B Biol Sci. 2011;366:241-50. DOI: 10.1098/rstb.2010.0230. PMID: 21149359.
  1. Coronado VG, McGuire LC, Faul M, et al. Traumatic brain injury epidemiology and public health issues. Brain Injury Medicine, 2nd Edition: Principles and Practice. 2012;84:84-100.
  2. Bruns Jr J, Hauser WA. The epidemiology of traumatic brain injury: a review. Epilepsia. 2003;44:2-10. DOI: 10.1046/j.1528-1157.44.s10.3.x. PMID: 14511388.
  3. Gardner RC, Dams-O'Connor K, Morrissey MR, Manley GT. Geriatric traumatic brain injury: epidemiology, outcomes, knowledge gaps, and future directions. J Neurotrauma. 2018;35:889-906. DOI: 10.1089/neu.2017.5371. PMID: 29212411.
  4. Thurman DJ, Alverson C, Dunn KA, et al. Traumatic brain injury in the United States: a public health perspective. J Head Trauma Rehabil. 1999;14:602-15. DOI: 10.1097/00001199-199912000-00009. PMID: 10671706.
  5. Summers CR, Ivins B, Schwab KA. Traumatic brain injury in the United States: an epidemiologic overview. Mt Sinai J Med. 2009;76:105-10. DOI: 10.1002/msj.20100. PMID: 19306375.
  6. Lashkarizadeh MM, Ghaedi A, Abolghasemi H, et al. Comparison of gauze packing, sponge-based, and hemostatic surgicel wound stasis dressings to treat hemorrhages from grade IV liver injuries: An experimental study. Heliyon. 2024;10:e39894. Doi:10.1016/j.heliyon.2024.e39894. PMID: 39539973.
  7. Borg J, Holm L, Cassidy JD, et al. Diagnostic procedures in mild traumatic brain injury: results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. J Rehabil Med. 2004;36:61-75. DOI: 10.1080/16501960410023822. PMID: 15083871.
  8. Cassidy JD, Cancelliere C, Carroll LJ, et al. Systematic review of self-reported prognosis in adults after mild traumatic brain injury: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis. Arch Phys Med Rehabil. 2014;95:S132-S51. DOI: 10.1016/j.apmr.2013.08.299. PMID: 24581902.
  9. Hashemi SS, Mahmoodi M|, Tohidinik H, et al. The Epidemiology of Burn and Lethal Area of Fifty Percentage (LA50) in Children in Shiraz, Southern Iran. World J Plast Surg. 2021;10:66-70. DOI: 10.29252/wjps.10.1.66. PMID: 33833956.
  10. Dixon KJ. Pathophysiology of traumatic brain injury. Phys Med Rehabil Clin N Am. 2017;28:215-25. DOI: 10.1016/j.pmr.2016.12.001. PMID: 28390509.
  11. Werner C, Engelhard K. Pathophysiology of traumatic brain injury. Br J Anaesth. 2007;99:4-9. doi: 10.1093/bja/aem131. PMID: 17573392.
  12. Elhaie M, Koozari A, Mozafari M, et al. The Role of MRI as a key evaluator of mesenchymal stem Cell Therapy in Multiple Sclerosis: A systematic review and meta-analysis. J Neuroradiol. 2025;52:101374. DOI: 10.1016/j.neurad.2025.101374. PMID: 40714636.
  13. Witteveen E, Wieske L, van der Poll T, et al. Increased early systemic inflammation in ICU-acquired weakness; a prospective observational cohort study. Crit Care Med. 2017;45:972-9. DOI: 10.1097/CCM.0000000000002408. PMID: 28350642.
  14. Rodney T, Osier N, Gill J. Pro-and anti-inflammatory biomarkers and traumatic brain injury outcomes: a review. Cytokine. 2018;110:248-56. DOI: 10.1016/j.cyto.2018.01.012. PMID: 29396048.
  15. Lustenberger T, Kern M, Relja B, et al. The effect of brain injury on the inflammatory response following severe trauma. Immunobiology. 2016;221:427-31. DOI: 10.1016/j.imbio.2015.11.011. PMID: 26688509.
  16. Aggarwal B. The gut-brain axis: exploring the bidirectional communication between the gut microbiome and the brain. J Forensic Sci Res. 2024;8:047-57.
  17. Louwies T, Johnson AC, Orock A, et al. The microbiota-gut-brain axis: an emerging role for the epigenome. Exp Biol Med (Maywood). 2020;245:138-45. DOI: 10.1177/1535370219891690. PMID: 31805777.
  18. Masoumi SJ, Mehrabani D, Saberifiroozi  M, et al. The effect of yogurt fortified with Lactobacillus acidophilus and Bifidobacterium sp. probiotic in patients with lactose intolerance. Food Sci Nutr. 2021;9:1704-1711. DOI: 10.1002/fsn3.2145. PMID: 33747481.
  19. Azad A, Ranjbaran AR, Zareshahrabadi Z, et al. Protective effects of the probiotic bacterium streptococcus thermophilus on candida albicans morphogenesis and a murine model of oral candidiasis. Iran J Med Sci. 2021;46:207-217. DOI: 10.30476/ijms.2020.82080.0. PMID: 34083853.
  20. Scholz-Ahrens KE, Schaafsma G, van den Heuvel EG, et al. Effects of prebiotics on mineral metabolism. Am J Clin Nutr. 2001;73:459s-64s. DOI: 10.1093/ajcn/73.2.459s. PMID: 11157358.
  21. Noshadi N, Sabet SS, Sanaie S, et al. The effects of seven-strain probiotic supplementation on cell adhesion molecules, oxidative stress and antioxidant parameters in patients with traumatic brain injury: a randomised controlled clinical trial. Br J Nutr. 2025;133:892-900. DOI: 10.1017/S0007114524003234. PMID: 39844647.
  22. Abbaszadeh SH, Yousefi M, Arefhosseini SR, et al. Effect of a seven-strain probiotic on dietary intake, inflammatory markers, and T-cells in severe traumatic brain injury patients: A randomized, double-blind, placebo-controlled trial. Sci Prog. 2024;107:00368504241259299. DOI: 10.1177/00368504241259299. PMID: 39196597.
  23. Pagkou D, Kogias E, Foroglou N, et al. Probiotics in traumatic brain injury: new insights into mechanisms and future perspectives. J Clin Med. 2024;13:4546. DOI: 10.3390/jcm13154546. PMID: 39124812.
  24. Vosoughian F, Rezanejad Z, Bahrami O, et al. Modulation of Gut Microbiota and Gut-Brain Axis as a Therapeutic approach in Traumatic brain injury: Implications for Neurological Outcomes. medRxiv. 2025. DOI:10.1101/2025.10.15.25338135.
  25. Mirzaeian S, Saraf-Bank S, Entezari MH, et al. Effects of synbiotic supplementation on microbiota-derived protein-bound uremic toxins, systemic inflammation, and biochemical parameters in patients on hemodialysis: A double-blind, placebo-controlled, randomized clinical trial. Nutrition. 2020;73:110713. DOI: 10.1016/j.nut.2019.110713. PMID: 32120316.
  26. Ducros V, Arnaud J, Tahiri M, et al. Influence of short-chain fructo-oligosaccharides (sc-FOS) on absorption of Cu, Zn, and Se in healthy postmenopausal women. J Am Coll Nutr. 2005;24:30-7. DOI: 10.1080/07315724.2005.10719440. PMID: 15670982.
  27. Rincón D, Vaquero J, Hernando A, et al. Oral probiotic VSL# 3 attenuates the circulatory disturbances of patients with cirrhosis and ascites. Liver Int. 2014;34:1504-12. DOI: 10.1111/liv.12539. PMID: 24661740.
  28. Firouzi S, Mohd-Yusof BN, Majid HA, et al. Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: a randomized controlled trial. BMC Complement Altern Med. 2015;15:433. DOI: 10.1186/s12906-015-0952-5. PMID: 26654906.
  29. Eslamparast T, Poustchi H, Zamani F, Sharafkhah M, Malekzadeh R, Hekmatdoost A. Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study. Am J Clin Nutr. 2014;99:535-42. DOI: 10.3945/ajcn.113.068890. PMID: 24401715.
34. Liu C, Yang L, Wei W, et al Efficacy of probiotics/synbiotics supplementation in patients with chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials. Front Nutr. 2024;11:1434613. DOI: 10.3389/fnut.2024.1434613. PMID: 39166132.

آمار
تعداد مشاهده مقاله: 1


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب