LinkedIn

 آمار

تعداد نشریات21
تعداد شماره‌ها1,294
تعداد مقالات11,825
تعداد مشاهده مقاله83,186,845
تعداد دریافت فایل اصل مقاله121,953,020
Jandari, Sajedeh, Bagheri Moghaddam, Ahmad, Sedaghat, Alireza, Hadizadeh, Melika, Kalali Nasrabadi, kimia, Mowdoudi, Samira, Hébert, James, Tabesh, Hamed, Safarian, Mohammad, Abbaspour, Mohammadreza, Ghayour-Mobarhan, Majid, Rezvani, Reza. (1405). Development of an Anti-inflammatory Oral Nutrition Supplement Formula in Critically Ill Patients Admitted to Intensive Care Unit. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijns.2026.106604.1453
Sajedeh Jandari; Ahmad Bagheri Moghaddam; Alireza Sedaghat; Melika Hadizadeh; kimia Kalali Nasrabadi; Samira Mowdoudi; James R. Hébert; Hamed Tabesh; Mohammad Safarian; Mohammadreza Abbaspour; Majid Ghayour-Mobarhan; Reza Rezvani. "Development of an Anti-inflammatory Oral Nutrition Supplement Formula in Critically Ill Patients Admitted to Intensive Care Unit". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/ijns.2026.106604.1453
Jandari, Sajedeh, Bagheri Moghaddam, Ahmad, Sedaghat, Alireza, Hadizadeh, Melika, Kalali Nasrabadi, kimia, Mowdoudi, Samira, Hébert, James, Tabesh, Hamed, Safarian, Mohammad, Abbaspour, Mohammadreza, Ghayour-Mobarhan, Majid, Rezvani, Reza. (1405). 'Development of an Anti-inflammatory Oral Nutrition Supplement Formula in Critically Ill Patients Admitted to Intensive Care Unit', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijns.2026.106604.1453
Jandari, Sajedeh, Bagheri Moghaddam, Ahmad, Sedaghat, Alireza, Hadizadeh, Melika, Kalali Nasrabadi, kimia, Mowdoudi, Samira, Hébert, James, Tabesh, Hamed, Safarian, Mohammad, Abbaspour, Mohammadreza, Ghayour-Mobarhan, Majid, Rezvani, Reza. Development of an Anti-inflammatory Oral Nutrition Supplement Formula in Critically Ill Patients Admitted to Intensive Care Unit. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/ijns.2026.106604.1453

Development of an Anti-inflammatory Oral Nutrition Supplement Formula in Critically Ill Patients Admitted to Intensive Care Unit

International Journal of Nutrition Sciences
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 01 شهریور 1405    اصل مقاله (1006.41 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/ijns.2026.106604.1453
نویسندگان
Sajedeh Jandari1، 2؛ Ahmad Bagheri Moghaddam3؛ Alireza Sedaghat3؛ Melika Hadizadeh2؛ kimia Kalali Nasrabadi2؛ Samira Mowdoudi1؛ James R. Hébert4، 5؛ Hamed Tabesh6؛ Mohammad Safarian1؛ Mohammadreza Abbaspour7؛ Majid Ghayour-Mobarhan8؛ Reza Rezvani* 1
1Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Nutrition, Varastegan Institute for Medical Sciences, Mashhad, Iran
3Service of Intensive Care Medicine, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
4Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA
5Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA
6Department of Medical Informatics, Mashhad University of Medical Sciences, Mashhad, Iran
7Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
8Assistant professor in the Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Critical illnesses such as sepsis and acute respiratory distress syndrome (ARDS) can lead to organ dysfunction and high mortality and present significant challenges in in intensive care units (ICUs). Current research highlights the importance of nutritional support in managing inflammation and immune response. This study developed a novel anti-inflammatory formula targeting inflammatory markers in ICU patients.
Methods: Seventy-four critically ill adult patients were randomly divided into two groups within 24-48 hours of ICU admission. Two treatment interventions were used; while the control group received the standard oral nutritional supplement (ONS) formula as two times gavage meal, and the intervention group received an anti-inflammatory formula with a low inflammatory profile in the same way as control group for 14 days. Data collection included demographic information and blood samples at baseline, day 7, and day 14.
Results: Nutritional intervention in modulating inflammation and immune response in critically ill patients, particularly those experiencing systemic inflammatory response syndrome (SIRS) or sepsis was verified.
Conclusion: This study considering the efficacy of low inflammatory index formulas and their effects on clinical outcomes in critically ill trauma patients.

تازه های تحقیق

Sajedeh Jandari (Google Scholar)

Reza Rezvani (Google Scholar)

کلیدواژه‌ها
Anti-inflammatory؛ Nutrition؛ Oral supplement؛ Intensive care unit؛ Iran
مراجع
  1. Lat TI, McGraw MK, White HD. Gender Differences in Critical Illness and Critical Care Research. Clin Chest Med. 2021;42:543-55. DOI: 10.1016/j.ccm.2021.04.012. PMID: 34353458.
  2. Santacroce E, D'Angerio M, Ciobanu AL, et al. Advances and Challenges in Sepsis Management: Modern Tools and Future Directions. Cells. 2024;13:439. DOI: 10.3390/cells13050439. PMID: 38474403.
  3. Lashkarizadeh MM, Ghaedi A, Abolghasemi H, et al. Comparison of gauze packing, sponge-based, and hemostatic surgicel wound stasis dressings to treat hemorrhages from grade IV liver injuries: An experimental study. Heliyon. 2024;10:e39894. DOI: 10.1016/j.heliyon.2024.e39894. PMID: 39539973.
  4. Moradi AM, Aj O, Paydar S, et al. The effect of blood loss in the presence and absence of severe tissue damage on hemodynamic and metabolic parameters in experimental rat model. Emerg (Tehran). 2014;3:150-154. PMID: 26495405.
  5. Mahan LK, Raymond JL. Krause's food & the nutrition care process-e-book: Elsevier Health Sciences; 2016.
  6. Rousseau A-F, Martindale R. Nutritional and metabolic modulation of inflammation in critically ill patients: a narrative review of rationale, evidence and grey areas. Ann Intensive Care. 2024;14:121. DOI: 10.1186/s13613-024-01350-x. PMID: 39088114.
  7. Mehrabani D, Vahedi M, Eftekhari MH, et al. Food avoidance in patients with ulcerative colitis: a review. Int J Nutr Sci. 2018;2:189-95.
  8. Moatari-Kazeruni M, Daryanoosh F, Mehrabani D. The Effect Of 8 Weeks Anaerobic Exercise And Omega 3 On Inflammatory Factors In Male Rat. J Sport Physiol. 2012;15:97-108.
  9. Hegazi RA, Wischmeyer PE. Clinical review: optimizing enteral nutrition for critically ill patients-a simple data-driven formula. Crit Care. 2011;15:234. DOI: 10.1186/cc10430. PMID: 22136305.
  10. Calder PC. Immunonutrition. BMJ. 2003;327:117-8. DOI: 10.1136/bmj.327.7407.117. PMID: 12869428.
  11. Calder PC. n− 3 Fatty acids, inflammation, and immunity—Relevance to postsurgical and critically III patients. Lipids. 2004;39:1147-61. DOI: 10.1007/s11745-004-1342-z. PMID: 15736910.
  12. McCarthy MS, Martindale RG. Immunonutrition in Critical Illness: What Is the Role? Nutr Clin Pract. 2018;33:348-58. DOI: 10.1002/ncp.10102. PMID: 29878555.
  13. Lopez-Delgado JC, Grau-Carmona T, Trujillano-Cabello J, et al. The Effect of Enteral Immunonutrition in the Intensive Care Unit: Does It Impact on Outcomes? Nutrients. 2022;14:1904. DOI: 10.3390/nu14091904. PMID: 35565870.
  14. Abunnaja S, Cuviello A, Sanchez JA. Enteral and parenteral nutrition in the perioperative period: state of the art. Nutrients. 2013;5:608-23. DOI: 10.3390/nu5020608. PMID: 23429491.
  15. Klek S, Sierzega M, Szybinski P, et al. Perioperative nutrition in malnourished surgical cancer patients–a prospective, randomized, controlled clinical trial. Clin Nutr. 2011;30:708-13. DOI: 10.1016/j.clnu.2011.07.007. PMID: 21820770.
  16. Marano L, Porfidia R, Pezzella M, et al. Clinical and immunological impact of early postoperative enteral immunonutrition after total gastrectomy in gastric cancer patients: a prospective randomized study. Ann Surg Oncol. 2013;20:3912-8. DOI: 10.1245/s10434-013-3088-1. PMID: 23838912.
  17. Shivappa N, Steck SE, Hurley TG, et al. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr. 2014;17:1689-96. DOI: 10.1017/S1368980013002115. PMID: 23941862.
  18. Jandari S, Rezvani R, Yousefian S, et al. The effect of low dietary inflammatory index score formula on inflammatory, metabolic, and clinical outcomes in critically ill traumatic brain injury patients: A single-blind randomized controlled pilot study. Food Sci Nutr. 2023;11:3365-75. DOI: 10.1002/fsn3.3326. PMID: 37324871.
  19. Chan AW, Tetzlaff JM, Gøtzsche PC, et al. SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ. 2013;346:e7586. DOI: 10.1136/bmj.e7586. PMID: 23303884.
  20. Pahlavani N, Sedaghat A, Ferns GA, et al. The Effects of Melatonin and Propolis on Markers of Inflammation, Oxidative Stress, Clinical Outcomes, and Survival Rate in Patients with Primary Sepsis Hospitalized in Intensive Care Unit: A Randomized Clinical Trial. Res Square. 2020. DOI: 10.21203/rs.3.rs-56718/v1.
  21. Yahyapoor F, Sedaghat A, Feizi A, et al. The effects of l-Carnitine supplementation on inflammatory markers, clinical status, and 28 days mortality in critically ill patients: A double-blind, randomized, placebo-controlled trial. Clin Nutr ESPEN. 2022;49:61-7. DOI: 10.1016/j.clnesp.2022.04.001. PMID: 35623869.
  22. Zahedi H, Hosseinzadeh‐Attar MJ, Shadnoush M, et al. Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients: A randomized double‐blind placebo‐controlled trial. Phytother Res. 2021;35:4605-15. DOI: 10.1002/ptr.7179. PMID: 34080237.
  23. Mehrabani D, Farjam M, Geramizadeh B, et al. The healing effect of curcumin on burn wounds in rat. World J Plast Surg. 2015;4:29-35. PMID: 25606474.
  24. Panjehshahin MR, Owji AA, Mehrabani D, et al. Effect Of Curcumin On Cholesterol Gall-Stone Induction In Rats. J Appl Anim Res. 2003;23:75-80. DOI: 10.1080/09712119.2003.9706771.
  25. Rabbani-Haghighi N, Naghsh N, Mehrabani D. the protective effect of curcuma longa in thioacetamide-induced hepatic injury in rat. Global J Pharmacol. 2013;7:203-207. DOI: 10.5829/idosi.gjp.2013.7.2.74203.
  26. Kreymann K, Berger M, Deutz Ne, et al. ESPEN guidelines on enteral nutrition: intensive care. Clin Nutr. 2006;25:210-23. DOI: 10.1016/j.clnu.2006.01.021. PMID: 16697087.
  27. Oh HJ, An JN, Oh S, et al. VolumE maNagement Under body composition monitoring in critically ill patientS on CRRT: study protocol for a randomized controlled trial (VENUS trial). Trials. 2018;19:681. DOI: 10.1186/s13063-018-3056-y. PMID: 30541593.
  28. Rabb H, Griffin MD, McKay DB, et al. Inflammation in AKI: current understanding, key questions, and knowledge gaps. J Am Soc Nephrol. 2016;27:371-9. DOI: 10.1681/ASN.2015030261. PMID: 26561643.
  29. Alizadeh H, Daryanoosh F, Mehrabani D. Evaluating Inflammatory Index Changes And Muscle Injuries In Male Mice After 8 Weeks Of Aerobic Exercise And Omega-3 Consumption. J Sport Biosci. 2012;10:77-94. DOI: 10.22059/jsb.2012.21999.
  30. Malekzadeh S, Edalatmanesh MA, Mehrabani D, et al. Dental Pulp Stem Cells Transplantation Improves Passive Avoidance Memory and Neuroinflammation in Trimethyltin-Induced Alzheimer’s Disease Rat Model. Galen Med J. 2021;10:e2254. DOI: 10.31661/gmj.v10i.2254.
  31. Leng SX, McElhaney JE, Walston JD, et al. ELISA and multiplex technologies for cytokine measurement in inflammation and aging research. J Gerontol A Biol Sci Med Sci. 2008;63:879-84. DOI: 10.1093/gerona/63.8.879. PMID: 18772478.
  32. Goudarzi Z, Hoseini SE, Mehrabani D, et al. Change in blood chemistry, pro-inflammatory cytokines, and apoptotic genes following methamphetamine use in experimental rats. Periódico Tchê Química. 2020;17:1147-1159.
  33. Marik PE, Taeb AM. SIRS, qSOFA and new sepsis definition. J Thorac Dis. 2017;9:943-5. DOI: 10.21037/jtd.2017.03.125. PMID: 28523143.
  34. Reignier J, Rice TW, Arabi YM, et al. Nutritional Support in the ICU. BMJ. 2025;388:e077979. DOI: 10.1136/bmj-2023-077979. PMID: 39746713.
  35. Barker LA, Gray C, Wilson L, et al. Preoperative immunonutrition and its effect on postoperative outcomes in well-nourished and malnourished gastrointestinal surgery patients: A randomised controlled trial. Eur J Clin Nutr. 2015;67:802-7. DOI: 10.1038/ejcn.2013.117. PMID: 23801093.
  36. Falewee M, Schilf A, Boufflers E, et al. Reduced infections with perioperative immunonutrition in head and neck cancer: exploratory results of a multicenter, prospective, randomized, double-blind study. Clin Nutr. 2014;33:776-84. DOI: 10.1016/j.clnu.2013.10.006. PMID: 24182765.
  37. Yeh DD. Fueling recovery: evidence-based ICU nutrition and immunonutrition strategies in 2026. Trauma Surg Acute Care Open. 2026;11:e002284. DOI: 10.1136/tsaco-2026-002284. PMID: 42094750.
آمار
تعداد مشاهده مقاله: 6
تعداد دریافت فایل اصل مقاله: 3


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب