LinkedIn

 آمار

تعداد نشریات21
تعداد شماره‌ها1,293
تعداد مقالات11,808
تعداد مشاهده مقاله83,143,220
تعداد دریافت فایل اصل مقاله121,898,431
Hussein, Teeba Alaa, Rasool, Khetam Habeeb. (1405). Evaluation of Inflammatory Cytokines and Vitamin D3 Serum Levels in Patients with Tuberculosis in Baghdad, Iraq. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijns.2026.107042.1475
Teeba Alaa Hussein; Khetam Habeeb Rasool. "Evaluation of Inflammatory Cytokines and Vitamin D3 Serum Levels in Patients with Tuberculosis in Baghdad, Iraq". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/ijns.2026.107042.1475
Hussein, Teeba Alaa, Rasool, Khetam Habeeb. (1405). 'Evaluation of Inflammatory Cytokines and Vitamin D3 Serum Levels in Patients with Tuberculosis in Baghdad, Iraq', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijns.2026.107042.1475
Hussein, Teeba Alaa, Rasool, Khetam Habeeb. Evaluation of Inflammatory Cytokines and Vitamin D3 Serum Levels in Patients with Tuberculosis in Baghdad, Iraq. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/ijns.2026.107042.1475

Evaluation of Inflammatory Cytokines and Vitamin D3 Serum Levels in Patients with Tuberculosis in Baghdad, Iraq

International Journal of Nutrition Sciences
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 27 مرداد 1405    اصل مقاله (827.92 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/ijns.2026.107042.1475
نویسندگان
Teeba Alaa Hussein* ؛ Khetam Habeeb Rasool
Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
چکیده
Background: Tuberculosis (TB) due to Mycobacterium tuberculosis infection is a public health issue frequently connected with cytokine storm. Vitamin D3 deficiency was shown to increase the susceptibility to TB. This study assessed the serum levels of inflammatory cytokines and vitamin D3 in Iraqi patients infected to TB.
Methods: A total of 3 mL of blood was collected from 72 TB patients and 72 healthy controls to evaluate the interleukin-2 (IL-2), IL-10, and IL-17 levels by Enzyme-Linked Immunosorbent Assay (ELISA), and the vitamin D3 level using auto-analyzer.
Results: A significant increase in IL-2 (p<0.0001), IL-10 (p<0.0001), and IL-17 (p<0.05) in TB patients was noticed compared to control group. A significant decrease in vitamin D3 was observed in TB patients compared to control group (p<0.02). Among TB patients a significant increase was seen in IL-2 (p<0.002), IL-10 (p<0.05), and non-significant increase in IL-17 (p<0.13). A significant decrease in vitamin D3 (p<0.05) was demonstrated among drug resist patients compared to drug sensitive patients within TB group.
Conclusion: IL-2, IL-10, and IL-17 serum levels were illustrated to be useful immunodiagnostic markers between TB-infected patients and TB-uninfected individuals. Vitamin D3 was demonstrated to have supportive role in TB patients.
کلیدواژه‌ها
Tuberculosis؛ IL-2؛ IL-10؛ IL-17؛ Vitamin D3
مراجع
  1. Rahlwes KC, Dias BR, Campos PC, et al. Pathogenicity and virulence of Mycobacterium tuberculosis. Virulence. 2023;14:2150449. DOI: 10.1080/21505594.2022.2150449. PMID: 36419223.
  2. Goudarzi Z, Hoseini SE, Mehrabani D, et al. Change in blood chemistry, pro-inflammatory cytokines, and apoptotic genes following methamphetamine use in experimental rats. Periódico Tchê Química. 2020;17:1147-1159.‏ DOI: 10.52571/ptq.v17.n36.2020.1163_periodico36_pgs_1147_1159.pdf.
  3. Jassim AS, Ali EN, Auda IG, et al. Role of some Immunological and non-Immunological Parameters in Prognosis and diagnosis of Systemic lupus erythematosus in Iraqi women patients. Al-Mustansiriyah J Sci. 2023;34:29-36.‏ DOI: https://doi.org/10.23851/mjs.v34i4.1363.
  4. Lissoni P, Messina G, Pelizzoni F, et al. The fascination of cytokine immunological science. J Infectiol Epidemiol. 2020;3.‏
  5. Zhang R, Zhao Y, Chen X, et al. Low-dose IL-2 therapy in autoimmune diseases: an update review. Int Rev Immunol. 2024;43: 113-137. DOI: 10.1080/08830185.2023.2274574. PMID: 37882232.
  6. Li Y, Li X, Geng X, et al. The IL-2A receptor pathway and its role in lymphocyte differentiation and function. Cytokine Growth Factor Rev. 2022;67:66-79.‏ DOI: 10.1016/j.cytogfr.2022.06.004. PMID: 35803834.
  7. Soongsathitanon J, Homjan T, Pongcharoen S. Characteristic features of in vitro differentiation of human naïve CD4+ T cells to induced regulatory T cells (iTreg) and T helper (Th) 17 cells: Sharing of lineage-specific markers. Heliyon. 2024;10:e31394.‏ DOI: 10.1016/j.heliyon.2024.e31394. PMID: 38807879.
  8. Khanna H, Gupta S, and Sheikh Y. Cell-Mediated Immune Response Against Mycobacterium tuberculosis and Its Potential Therapeutic Impact. J Interferon Cytokine Res. 2024;44:244-259.‏ DOI: 10.1089/jir.2024.0030. PMID: 38607324.
  9. Liu C, Chu D, Kalantar‐Zadeh K, et al. Cytokines: from clinical significance to quantification. Adv Sci. 2021;8:e2004433.‏ DOI: 10.1002/advs.202004433. PMID: 34114369.
  10. Martinez-Espinosa I, Serrato JA, Ortiz-Quintero B. Role of IL-10-producing natural killer cells in the regulatory mechanisms of inflammation during systemic infection. Biomolecules. 2021;12:4.‏ DOI: 10.3390/biom12010004. PMID: 35053151.
  11. Arango Duque G, Descoteaux A. Macrophage cytokines: involvement in immunity and infectious diseases. Front Immunol. 2014;5:491.‏ DOI: 10.3389/fimmu.2014.00491.PMID: 25339958
  12. Shibabaw T, Teferi B, Ayelign B. The role of Th-17 cells and IL-17 in the metastatic spread of breast cancer: As a means of prognosis and therapeutic target. Front Immunol. 2023;14:1094823.‏ DOI:10.3389/fimmu.2023.1094823. PMID: 36993955.
  13. McGeachy MJ, Cua DJ, Gaffen SL. The IL-17 Family of Cytokines in Health and Disease. Immunity. 2019;50: 892–906. DOI:10.1016/j.immuni.2019.03.021. PMID: 30995505.
  14. Hult C, Mattila JT, Gideon HP, et al. Neutrophil dynamics affect mycobacterium tuberculosis granuloma outcomes and dissemination. Front Immunol. 2021;12:712457.‏ DOI: 10.3389/fimmu.2021.712457. PMID: 34675916.
  15. Mehrabani D, Vahedi M, Eftekhari MH, et al. Food Avoidance in Patients with Ulcerative Colitis: A Review. Int J Nutr Sci. 2017;2:189-195.
  16. Sanlier N, Guney-Coskun M. Vitamin D, the immune system, and its relationship with diseases. Egyptian Pediatric Association Gazette. 2022;70:39.
  17. Nouri-Vaskeh M, Sadeghifard S, Saleh P, et al.. Vitamin D Deficiency among Patients with Tuberculosis: a Cross-Sectional Study in Iranian-Azari Population. Tanaffos. 2019;18:11-17. PMID: 31423135
  18. Mamadapur VK, Nagaraju S, Prabhu MM. Comparative Study of Vitamin D Levels in Newly Diagnosed Tuberculosis and a Normal Population. Medicina. 2024;60:685.‏ DOI: 10.3390/medicina60050685. PMID: 38792867.
  19. Ghaseminejad-Raeini A, Ghaderi A, Sharafi A, et al. Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review. Front Immunol. 2023;14:950465.‏ doi: 10.3389/fimmu.2023.950465. PMID: 37520529.
  20. Xu L, Cui G, Jia H, et al. Decreased IL-17 during treatment of sputum smear-positive pulmonary tuberculosis due to increased regulatory T cells and IL-10. J Transl Med. 2016;14:179. DOI: 10.1186/s12967-016-0909-6. PMID: 27311307.
  21. Rekha RS, Mily A, Sultana T, et al. Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D 3 as host directed therapy. BMC Infect Dis. 2018;18:303.‏ DOI: 10.1186/s12879-018-3203-9. PMID: 29973153.
  22. Suwandi GS, Sugiri YJ, Astuti TW, et al. Association of Interleukin-2 (IL-2) Levels With Acid-Fast Bacillus (AFB) Sputum Conversion In Drug-Resistant Pulmonary Tuberculosis Patient. Respiratory Sci. 2022;3:1-13.‏ DOI: DOI:10.36497/respirsci.v3i1.52.
  23. da Silva Graça Amoras E, de Morais TG, do Nascimento Ferreira R, et al. Association of cytokine gene polymorphisms and their impact on active and latent tuberculosis in Brazil’s Amazon region. Biomolecules. 2023;13:1541.‏ DOI: 10.3390/biom13101541. PMID: 37892223.
  24. Nisa A, Kipper FC, Panigrahy D, et al. Different modalities of host cell death and their impact on Mycobacterium tuberculosis infection. Am J Physiol Cell Physiol. 2022;323:C1444-C1474.‏ DOI: 10.1152/ajpcell.00246.2022. PMID: 36189975.
  25. Davarpanah MA, Rafiee GH, Mehrabani D. The Prevalence Of M. Tuberculosis Infection And Disease In HIV Positive Individuals In Shiraz, Southern Iran. Iran Red Crescent Med J. 2009;11:199-202.‏
  26. Singer M, Elsayed AM, Husseiny MI. Regulatory T-cells: The Face-off of the Immune Balance. Front Biosci (Landmark Ed). 2024;9:377.‏ DOI: 10.31083/j.fbl2911377. PMID: 39614434.
  27. Clifford V, Tebruegge M, Zufferey C, et al. Cytokine biomarkers for the diagnosis of tuberculosis infection and disease in adults in a low prevalence setting. Tuberculosis. 2019;114:91-102.‏ DOI: 10.1016/j.tube.2018.08.011. PMID: 30711163.
  28. Sampath P, Rajamanickam A, Thiruvengadam K, et al.. Cytokine upsurge among drug-resistant tuberculosis endorse the signatures of hyper inflammation and disease severity. Sci Rep. 2023;13:785. DOI:10.1038/s41598-023-27895-8. DOI: 10.1038/s41598-023-27895-8. PMID: 36646786.
  29. Alfatlawi WRO, Khudhair MK, Ali JA. Detection and role of some interleukins and tumor necrotic factor alpha among patients with tuberculosis. Med J Babylon. 2024;21:878-883. DOI: 10.4103/MJBL.MJBL_273_24. ‏
  30. Cocco N, Gargioni G, Gilpin C, et al. WHO consolidated guidelines on drug-resistant tuberculosis treatment. World Health Organization.‏
  31. Parsa F, Hoseini SE, Mehrabani D, et al. The effect of Cannabis sativa on memory, apoptotic genes and inflammatory cytokines in rat. Acad J Health Sci Med Balear. 2021;36:96-101.‏
  32. Olubunmi OA, Omosigho PO, Olaniyan MF. A review of pro-inflammatory and anti-inflammatory roles of cytokines in tuberculosis disease management. Sokoto J Med Lab Sci. 2024;9:248-257.‏ DOI: 10.4314/sokjmls.v9i2.29
  33. Hem R, Neha F, Kumar A, et al. evaluating vitamin-d insufficiency in patients with pulmonary tuberculosis: a case-control study. J Populat Therap Clin Pharmacol. 2024;31: 2867-2872. DOI: 10.53555/jptcp.v31i6.7124.
  34. Jebur RS, ALkhafaji DAH, Mohammed A, et al. Prevalence of Vitamin D Deficiency among Iraqi People. South East Eur J Public Health. 2024;245-251. DOI:10.70135/seejph.vi.1063.
  35. Jabal SK, Mohammed LY, Mankh AA. Association of Vitamin D level with Tuberculosis in Iraqi patients. Al-Nisour J Med Sci. 2020;2.
  36. Salim S, Ghassan K, Al-Temimi AA. Prevalence of vitamin D Deficiency among Population in Iraq. Int J Med Sci Clin Res Stud. 2023;3:731-4.‏ DOI: 10.47191/ijmscrs/v3-i4-29.
  37. Shepherd N, Alasdair L. Biological Differences Between the Sexes ans Susceptibility to Tuberculosis. J Infect Dis. 2014;209:S100-S106. DOI: 10.1093/infdis/jiu147. PMID: 24966189.
  38. Horton KC, MacPherson P, Houben RM, et al. Sex differences in tuberculosis burden and notifications in low-and middle-income countries: a systematic review and meta-analysis. PLoS Med. 2016;13:e1002119.‏‏ DOI: 10.1371/journal.pmed.1002119.PMID: 27598345.
  39. Jimenez-Corona ME, Garcia-Garcia L, DeRiemer K, et al. Gender differentials of pulmonary tuberculosis transmission and reactivation in an endemic area. Thorax. 2006;61:348-353.‏ DOI: 10.1136/thx.2005.049452. PMID: 16449260.
  40. Rao S. Tuberculosis and patient gender: An analysis and its implications in tuberculosis control. Lung India. 2009;26:46-47.‏ DOI: 10.4103/0970-2113.48897. PMID: 20440394.
آمار
تعداد مشاهده مقاله: 5
تعداد دریافت فایل اصل مقاله: 1


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب