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Raeissadat, Seyed Ahmad, Rayegani, Seyed Mansoor, Keshavarzi, Elahe, Mahdi Kaghazi, Amir Hossein, Nazari Nodoushan, Ali. (1405). Hyaluronic Acid in Spinal Disorders: A Narrative Review of Hot Spots and Research Perspectives. سامانه مدیریت نشریات علمی, 51(9), 608-616. doi: 10.30476/ijms.2025.107196.4155
Seyed Ahmad Raeissadat; Seyed Mansoor Rayegani; Elahe Keshavarzi; Amir Hossein Mahdi Kaghazi; Ali Nazari Nodoushan. "Hyaluronic Acid in Spinal Disorders: A Narrative Review of Hot Spots and Research Perspectives". سامانه مدیریت نشریات علمی, 51, 9, 1405, 608-616. doi: 10.30476/ijms.2025.107196.4155
Raeissadat, Seyed Ahmad, Rayegani, Seyed Mansoor, Keshavarzi, Elahe, Mahdi Kaghazi, Amir Hossein, Nazari Nodoushan, Ali. (1405). 'Hyaluronic Acid in Spinal Disorders: A Narrative Review of Hot Spots and Research Perspectives', سامانه مدیریت نشریات علمی, 51(9), pp. 608-616. doi: 10.30476/ijms.2025.107196.4155
Raeissadat, Seyed Ahmad, Rayegani, Seyed Mansoor, Keshavarzi, Elahe, Mahdi Kaghazi, Amir Hossein, Nazari Nodoushan, Ali. Hyaluronic Acid in Spinal Disorders: A Narrative Review of Hot Spots and Research Perspectives. سامانه مدیریت نشریات علمی, 1405; 51(9): 608-616. doi: 10.30476/ijms.2025.107196.4155

Hyaluronic Acid in Spinal Disorders: A Narrative Review of Hot Spots and Research Perspectives

Iranian Journal of Medical Sciences
مقاله 1، دوره 51، شماره 9، آذر 2026، صفحه 608-616    اصل مقاله (312.09 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2025.107196.4155
نویسندگان
Seyed Ahmad Raeissadat1؛ Seyed Mansoor Rayegani2؛ Elahe Keshavarzi* 3؛ Amir Hossein Mahdi Kaghazi3؛ Ali Nazari Nodoushan3
1Clinical Research Development Center, Shahid Modarres Educational Hospital, Department of Physical Medicine and Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2Department of Physical Medicine and Rehabilitation, Physical Medicine and Rehabilitation Research Center, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Department of Physical Medicine and Rehabilitation, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Hyaluronic acid (HA), a cell behavior modulator with anti-aging, anti-inflammatory, and immunomodulatory properties, is a member of the glycosaminoglycan family. In orthopedics, HA has been utilized for its chondroprotective, anti-inflammatory, immunomodulatory, and cushioning effects, owing to its extreme lubricity and hydrophilicity. HA has been investigated for various diagnostic and therapeutic applications in spinal diseases. 
This narrative review aimed to clarify that HA may serve as a biomarker in spinal diseases and as a therapeutic agent in several applications, such as tissue engineering for intervertebral disc degeneration, management of spinal pain, prevention of postoperative epidural fibrosis, and minimally invasive treatment of vertebral compression fractures. 
Although the efficacy of HA as a viable alternative or adjunct to existing therapies for various spinal conditions has been investigated, further experimental and clinical studies are required to explore regulatory considerations, refine clinical applications, and develop potential interdisciplinary management strategies before general recommendations can be established.

تازه های تحقیق

Seyed Ahmad, Raeissadat (Google Scholar)
Elahe Keshavarzi (Google Scholar)

کلیدواژه‌ها
Epidural fibrosis؛ Hyaluronic acid؛ Intervertebral disc؛ Pain؛ Spinal fracture
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آمار
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