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Sankar, Divyashree, Sukumaran, Gheena. (1406). A Comparative Study of Moderately and Well-Differentiated Oral Squamous Cell Carcinoma: Clinicopathological, Immunohistochemical analysis and Quality of Life Outcomes. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2026.110691.2408
Divyashree Sankar; Gheena Sukumaran. "A Comparative Study of Moderately and Well-Differentiated Oral Squamous Cell Carcinoma: Clinicopathological, Immunohistochemical analysis and Quality of Life Outcomes". سامانه مدیریت نشریات علمی, , , 1406, -. doi: 10.30476/mejc.2026.110691.2408
Sankar, Divyashree, Sukumaran, Gheena. (1406). 'A Comparative Study of Moderately and Well-Differentiated Oral Squamous Cell Carcinoma: Clinicopathological, Immunohistochemical analysis and Quality of Life Outcomes', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2026.110691.2408
Sankar, Divyashree, Sukumaran, Gheena. A Comparative Study of Moderately and Well-Differentiated Oral Squamous Cell Carcinoma: Clinicopathological, Immunohistochemical analysis and Quality of Life Outcomes. سامانه مدیریت نشریات علمی, 1406; (): -. doi: 10.30476/mejc.2026.110691.2408

A Comparative Study of Moderately and Well-Differentiated Oral Squamous Cell Carcinoma: Clinicopathological, Immunohistochemical analysis and Quality of Life Outcomes

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 فروردین 1406    اصل مقاله (1.63 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2026.110691.2408
نویسندگان
Divyashree Sankar؛ Gheena Sukumaran*
Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Chennai, Tamil Nadu, India
چکیده
Background: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy with variable prognosis depending on histopathological differentiation. The present study aimed to comparatively analyse clinicopathological features, immunohistochemical profiles, and quality of life in moderately-differentiated squamous cell carcinoma (MDSCC) and well-differentiated squamous cell carcinoma (WDSCC).
Method: This retrospective study aimed to compare the clinicopathological characteristics, immunohistochemical expression of epidermal growth factor receptor (EGFR) and tumour protein 63 (p63) and quality of life in MDSCC and WDSCC. A total number of 75 cases from each group were analysed for demographic, clinical, and pathological parameters, while immunohistochemical expression of EGFR and p63 was evaluated in 20 tissue samples (10 per group). Postoperative quality of life was assessed using physical, emotional, and functional indices. Statistical analysis was performed using SPSS version 26.0. Descriptive statistics, Student’s t-test, and Kaplan–Meier survival analysis were applied, with a P-value <0.05 considered to be statistically significant.
Results: MDSCC showed significantly greater tumour thickness, advanced stage, higher incidence of lymph node positivity, Extranodal extension, and microinvasion compared with WDSCC. WDSCC exhibited higher rates of bone invasion. Immunohistochemical analysis revealed significantly higher proportions of EGFR and p63-positive cells in WDSCC. Postoperative functional impairments variably affected speech, swallowing, and social, emotional well-being. Survival analysis indicated a better prognosis in WDSCC.
Conclusion: MDSCC exhibits a more aggressive clinicopathological profile, whereas WDSCC is associated with higher immunohistochemical marker expression, better quality of life, and improved survival rates.

تازه های تحقیق

Gheena Sukumaran (google scholar)

کلیدواژه‌ها
Oral squamous cell carcinoma؛ Human؛ Health؛ Mortality؛ Quality of life
مراجع
  1. Wéber A, Vignat J, Shah R, Morgan E, Laversanne M, Nagy P, et al. Global burden of bladder cancer mortality in 2020 and 2040 according to GLOBOCAN estimates. World J Urol. 2024;42:237. doi: 10.1007/s00345-024-04949-8. PMID: 38625417; PMCID: PMC11021283
  2. Tran CM, Kuroshima T, Oikawa Y, Michi Y, Kayamori K, Harada H. Clinicopathological and immunohistochemical characteristics of pigmented oral squamous cell carcinoma. Oncol Lett. 2021;21:339. doi: 10.3892/ol.2021.12600. PMID: 33692871; PMCID: PMC7933752.
  3. Wang S, Zheng Z. Advances in oral exfoliative cytology: From cancer diagnosis to systemic disease detection. Diagn Cytopathol. 2024;52:697-706. doi: 10.1002/dc.25400. PMID: 39219248.
  4. Safi AF, Kauke M, Grandoch A, Nickenig HJ, Drebber U, Zöller J, et al. Clinicopathological parameters affecting nodal yields in patients with oral squamous cell carcinoma receiving selective neck dissection. J Craniomaxillofac Surg. 2017;45:2092-6. doi: 10.1016/j.jcms.2017.08.020. PMID: 29033003.
  5. Sharma G, Sharma N, Joshi N, Nag BP. Clinicopathological, morphological and ki-67 proliferative index in oral squamous cell carcinoma in a tertiary care teaching hospital. J Diagn Pathol Oncol. 2019;4(1):1-8. doi: 18231/2581-3706.2019.0001.
  6. Kijowska J, Grzegorczyk J, Gliwa K, Jędras A, Sitarz M. Epidemiology, diagnostics, and therapy of oral cancer-update review. Cancers (Basel). 2024;16. doi: 10.3390/cancers16183156. PMID: 39335128; PMCID: PMC11430737.
  7. Tan Y, Wang Z, Xu M, Li B, Huang Z, Qin S, et al. Oral squamous cell carcinomas: state of the field and emerging directions. Int J Oral Sci. 2023;15:44. doi: 10.1038/s41368-023-00249-w. PMID: 37736748; PMCID: PMC10517027.
  8. Linsen SS, Gellrich NC, Krüskemper G. Age- and localization-dependent functional and psychosocial impairments and health related quality of life six months after OSCC therapy. Oral Oncol. 2018;81:61–8. doi: 10.1016/j.oraloncology.2018.04.011. PMID: 29884415.
  9. Meier JK, Schuderer JG, Zeman F, Klingelhöffer C, Hullmann M, Spanier G, et al. Health-related quality of life: a retrospective study on local vs. microvascular reconstruction in patients with oral cancer. BMC Oral Health. 2019;19:62. doi: 10.1186/s12903-019-0760-2. PMID: 31029131; PMCID: PMC6487048.
  10. Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, et al. Premalignant and malignant oral mucosal lesions: Clinical and pathological findings. J Am Acad Dermatol. 2019;81:59-71. doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325.
  11. Odell E, Kujan O, Warnakulasuriya S, Sloan P. Oral epithelial dysplasia: Recognition, grading and clinical significance. Oral Dis. 2021;27:1947-76. doi: 10.1111/odi.13993. PMID: 34418233.
  12. Mirhashemi M, Saghravanian N, Ghazi N, Abdoljavadi A. Histomorphometric analysis of oral squamous cell carcinoma, apparently normal adjacent mucosa and epithelial dysplasia. Indian J Otolaryngol Head Neck Surg. 2024;76(6):5478-85. doi: 10.1007/s12070-023-04315-5. PMID: 38157395.
  13. Mneimneh WS, Xu B, Ghossein C, Alzumaili B, Sethi S, Ganly I, et al. Clinicopathologic characteristics of young patients with oral squamous cell carcinoma. Head Neck Pathol. 2021;15:1099-108. doi: 10.1007/s12105-021-01320-w. PMID: 33797696; PMCID: PMC8633158
  14. He L, Wan M, Yang X, Meng H. Distant metastasis of oral squamous cell carcinoma: immune escape mechanism and new perspectives on treatment. Discov Oncol. 2025;16:257. doi: 10.1007/s12672-025-01997-3. PMID: 40024975; PMCID: PMC11872995
  15. Oikawa Y, Fukuda M, Noguchi Y, Ito K, Igarashi H, Takano H. Clinicopathological study of invasion patterns and late cervical lymph node metastasis in pT1/T2 oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 2025;54:1011-8. doi: 10.1016/j.ijom.2025.06.010. PMID: 40533378.
  16. Sawazaki-Calone I, Rangel A, Bueno AG, Morais CF, Nagai HM, Kunz RP, et al. The prognostic value of histopathological grading systems in oral squamous cell carcinomas. Oral Dis. 2015;21:755-61. doi: 10.1111/odi.12343. PMID: 25825335
  17. Morais HGF, Carlan LM, de Barros JM, Mafra RP, de Morais EF, da Silveira ÉJD, et al. Prognostic value of histopathological grading systems in lip and tongue squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2023:S2212-4403(23)00591-6. doi: 10.1016/j.oooo.2023.07.049. PMID: 39492302.
  18. Thomas B, Stedman M, Davies L. Grade as a prognostic factor in oral squamous cell carcinoma: a population-based analysis of the data. 2014;124:688–94. doi: 10.1002/lary.24357. PMID: 23945976.
  19. Khan SM, Prakash N, Mokashi RR, Khan S, Gajdhar VS, Manva MZ. Histopathological grades of oral squamous cell carcinoma a prognostic indicator: hospital-based study. Int J Med Res Heal Sci. 2022; 11(3):17-22.
  20. Cívico-Ortega JL, González-Ruiz I, Ramos-García P, Cruz-Granados D, Samayoa-Descamps V, González-Moles M. Prognostic and clinicopathological significance of epidermal growth factor receptor (EGFR) expression in oral squamous cell carcinoma: Systematic review and meta-analysis. Int J Mol Sci. 2023;24. doi: 10.3390/ijms241511888. PMID: 37569265; PMCID: PMC10419199.
  21. Kimura I, Kitahara H, Ooi K, Kato K, Noguchi N, Yoshizawa K, et al. Loss of epidermal growth factor receptor expression in oral squamous cell carcinoma is associated with invasiveness and epithelial-mesenchymal transition. Oncol Lett. 2016; 11:201-7. doi: 10.3892/ol.2015.3833. PMID: 26870189; PMCID: PMC4727181.
  22. Gonfloni S, Caputo V, Iannizzotto V. P63 in health and cancer. Int J Dev Biol. 2015;59:87-93. doi: 10.1387/ijdb.150045sg. PMID: 26374530.
  23. Pansini PF, do Valle IB, Damasceno TCD, de Abreu PM, Có ACG, López RVM, et al. Differential expression of potential biomarkers of oral squamous cell carcinoma development. Head Neck Pathol. 2021;15:1127-36. doi: 10.1007/s12105-021-01322-8. PMID: 33840043; PMCID: PMC8633043.
  24. Moses MA, George AL, Sakakibara N, Mahmood K, Ponnamperuma RM, King KE, et al. Molecular mechanisms of p63-mediated squamous cancer pathogenesis. Int J Mol Sci. 2019;20. doi: 10.3390/ijms20143590. PMID: 31340447; PMCID: PMC6678256.
  25. Bryne M, Koppang HS, Lilleng R, Kjaerheim A. Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value. J Pathol. 1992;166:375-81. doi: 10.1002/path.1711660409. PMID: 1517891.
  26. Arumuganainar D, Krishna Naik V, Ramadoss R, Balasundaram A, Victor DJ. Evaluation of CD44 antigen in type 2 diabetic patients with periodontitis: An immunohistochemical study. Dent Med Probl. 2024;61(2):225-31. doi: 10.17219/dmp/156225. PMID: 38567731.
  27. Fedchenko N, Reifenrath J. Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue - a review. Diagn Pathol. 2014;9:221. doi: 10.1186/s13000-014-0221-9. PMID: 25432701; PMCID: PMC4260254.
  28. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of head and neck tumours. 4th Lyon, France: International Agency for Research on Cancer; 2017.p.85.
  29. Yasin MM, Abbas Z, Hafeez A. Correlation of histopathological patterns of OSCC patients with tumor site and habits. BMC Oral Health. 2022;22:305. doi: 10.1186/s12903-022-02336-6. PMID: 35870917; PMCID: PMC9308193.
  30. Singh MP, Kumar V, Agarwal A, Kumar R, Bhatt ML, Misra S. Clinico-epidemiological study of oral squamous cell carcinoma: A tertiary care centre study in North India. J Oral Biol Craniofac Res. 2016;6:31-4. doi: 10.1016/j.jobcr.2015.11.002. PMID: 26937366; PMCID: PMC4756063
  31. Tranby EP, Heaton LJ, Tomar SL, Kelly AL, Fager GL, Backley M, et al. Oral cancer prevalence, mortality, and costs in medicaid and commercial insurance claims data. Cancer Epidemiol Biomarkers Prev. 2022;31:1849-57. doi: 10.1158/1055-9965.Epi-22-0114. PMID: 35732291; PMCID: PMC9437560
  32. Foy JP, Bertolus C, Boutolleau D, Agut H, Gessain A, Herceg Z, et al. Arguments to support a viral origin of oral squamous cell carcinoma in non-smoker and non-drinker patients. Front Oncol. 2020;10:822. doi: 10.3389/fonc.2020.00822. PMID: 32528893; PMCID: PMC7253757.
  33. Koo K, Mouradov D, Angel CM, Iseli TA, Wiesenfeld D, McCullough MJ, et al. Genomic signature of oral squamous cell carcinomas from non-smoking non-drinking patients. Cancers (Basel). 2021;13. doi: 10.3390/cancers13051029. PMID: 33804510; PMCID: PMC7957667.
  34. Mrosk F, Krom V, Doll C, Mödl L, Kreutzer K, Voss J, et al. Prediction of nodal disease in oral squamous cell carcinoma of the tongue: histopathological risk assessment with the focus on depth of invasion. Clin Oral Investig. 2024;28:466. doi: 10.1007/s00784-024-05863-4. PMID: 39105864; PMCID: PMC12287162.
  35. Viswanatha SC, Hedne N, Hasan S. Correlation between histological grading, LVI and PNI of carcinoma oral tongue to lymph node metastasis. Int J Otorhinolaryngol Head Neck Surg. 2019;5(1):159-64. doi:10.18203/issn.2454-5929.ijohns20185306.
  36. Kosgallana S, Jayasekara P, Abeysinghe P, Hjermstad M, Lalloo R. Translation and validation of Sinhala version of modified EORTC QLQ-OH15 in oral cancer patients who receive radiotherapy with or without chemotherapy in Sri Lanka. BMC Oral Health. 2022;22(1):359. doi:1007/s12663-025-02867-9.
  37. Taylor K, Singer S. Long-term quality of life in head and neck cancer patients: A systematic review. Der Onkologe. 2019;25(Suppl 2):125-31.
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