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Hamdy, Omar, Eldesouky, Rehab, Elsaid, Ahmed, Gerges, Elissia, Elsakti, Eyad, Belal, Kareem, Elbadrawy, Mohamed. (1406). Merkel Cell Carcinoma of the Skin: An Exceptionally Rare Entity with Unique Locality-Related Characteristics. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2026.110574.2402
Omar Hamdy; Rehab T Eldesouky; Ahmed S Elsaid; Elissia F Gerges; Eyad M Elsakti; Kareem K Belal; Mohamed Elbadrawy. "Merkel Cell Carcinoma of the Skin: An Exceptionally Rare Entity with Unique Locality-Related Characteristics". سامانه مدیریت نشریات علمی, , , 1406, -. doi: 10.30476/mejc.2026.110574.2402
Hamdy, Omar, Eldesouky, Rehab, Elsaid, Ahmed, Gerges, Elissia, Elsakti, Eyad, Belal, Kareem, Elbadrawy, Mohamed. (1406). 'Merkel Cell Carcinoma of the Skin: An Exceptionally Rare Entity with Unique Locality-Related Characteristics', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2026.110574.2402
Hamdy, Omar, Eldesouky, Rehab, Elsaid, Ahmed, Gerges, Elissia, Elsakti, Eyad, Belal, Kareem, Elbadrawy, Mohamed. Merkel Cell Carcinoma of the Skin: An Exceptionally Rare Entity with Unique Locality-Related Characteristics. سامانه مدیریت نشریات علمی, 1406; (): -. doi: 10.30476/mejc.2026.110574.2402

Merkel Cell Carcinoma of the Skin: An Exceptionally Rare Entity with Unique Locality-Related Characteristics

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 فروردین 1406    اصل مقاله (850 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2026.110574.2402
نویسندگان
Omar Hamdy* 1؛ Rehab T Eldesouky2؛ Ahmed S Elsaid3؛ Elissia F Gerges3؛ Eyad M Elsakti3؛ Kareem K Belal3؛ Mohamed Elbadrawy1
1Surgical Oncology Department, Oncology Center, Mansoura University, Mansoura, Egypt
2Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
3Intern, Mansoura University Hospitals, Mansoura, Egypt
چکیده
Background: Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine tumor, which is often misdiagnosed, resulting in most cases presenting with early metastasis. The present study aimed to highlight the incidence, clinical and diagnostic features, pathological characteristics, treatment, and outcomes of MCC.
Method: This is a retrospective single-center cohort study that included MCC patients who referred to our center between January 2008 and December 2024. Continuous variables were expressed as median values with interquartile ranges or mean values with standard deviation. Categorical variables were presented as frequencies and percentages. Statistical significance was set at P < 0.05.
Results: A total number of nine patients were included (three males, six females). The mean age at diagnosis was 66.3 ± 6.2 years. The lower limb was the most common tumor location (eight patients), and the mean tumor diameter was 54 ± 28 mm. Of these, six patients (66.7%) had clinically positive lymph nodes, and three (33.3%) had distant metastasis at presentation. Only one patient did not undergo surgery for the primary tumor. Also, four patients (44.4%) underwent regional lymphadenectomy. Adjuvant radiotherapy and chemotherapy were administered to 3 (33.3%) and 2 (22.2%) patients, respectively. During follow-up, one patient developed local recurrence, and two patients developed distant metastasis. Eventually, three patients died (33.3%), while six patients (66.7%) were lost to follow-up. The mean disease-free survival value was 4.6 ± 4.1 months, while the mean overall survival was 9.6 ± 9.1 months.
Conclusion: MCC exhibited distinct characteristics in our locality, particularly in tumor location and size. Early diagnosis and radical surgical intervention may improve outcomes.

تازه های تحقیق

Omar Hamdy (google scholar)

کلیدواژه‌ها
Merkel cell carcinoma؛ Neuroendocrine؛ Skin neoplasms؛ Prognosis
مراجع
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