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Pourfarzad, Kambiz, Soori, Rahman, Hamedchaman, Nader, Riahy, Simin. (1405). Inflammasome Suppression via Combined Training Modulates Downstream Cytokines (Interleukin-1β/Caspase-1) and Improves Insulin Resistance in Diabetic Rats. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2026.107912.4254
Kambiz Pourfarzad; Rahman Soori; Nader Hamedchaman; Simin Riahy. "Inflammasome Suppression via Combined Training Modulates Downstream Cytokines (Interleukin-1β/Caspase-1) and Improves Insulin Resistance in Diabetic Rats". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/ijms.2026.107912.4254
Pourfarzad, Kambiz, Soori, Rahman, Hamedchaman, Nader, Riahy, Simin. (1405). 'Inflammasome Suppression via Combined Training Modulates Downstream Cytokines (Interleukin-1β/Caspase-1) and Improves Insulin Resistance in Diabetic Rats', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2026.107912.4254
Pourfarzad, Kambiz, Soori, Rahman, Hamedchaman, Nader, Riahy, Simin. Inflammasome Suppression via Combined Training Modulates Downstream Cytokines (Interleukin-1β/Caspase-1) and Improves Insulin Resistance in Diabetic Rats. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/ijms.2026.107912.4254

Inflammasome Suppression via Combined Training Modulates Downstream Cytokines (Interleukin-1β/Caspase-1) and Improves Insulin Resistance in Diabetic Rats

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 07 مرداد 1405    اصل مقاله (659.57 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2026.107912.4254
نویسندگان
Kambiz Pourfarzad1؛ Rahman Soori2؛ Nader Hamedchaman3؛ Simin Riahy* 1
1Clinical Biomechanics and Ergonomics Center, Aja University of Medical Sciences, Tehran, Iran
2Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran
3Department of Exercise Physiology, Faculty of Sports Sciences, Shomal University, Amol, Iran
چکیده
Background: Diabetic Cardiomyopathy (DCM) is connected to prolonged systemic glucose metabolism and/or hyperinsulinemia-induced cardiac metaflammation. This study aims to investigate the effects of combined endurance and resistance training on the protein levels of nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3 (NLRP3), caspase-1, and interleukin -1β (IL-1β) in the myocardium of male rats with type 2 diabetes. 
Methods: In this experimental study, 24 male Wistar rats (8 weeks old, 260±20 g) were randomly divided into three groups: (n=8/groups): Normal Control (NC), Diabetes Control (DC), and Diabetes+Combined Training (DCT). After type 2 diabetes induction, the training group performed the combined training for 8 weeks, five sessions/week, in spring 2024 at AJA University of Medical Sciences. Approximately 48 hours following the end of the training protocol, blood samples and myocardium tissue were taken for subsequent assessment of inflammatory and biochemical markers. Group comparisons were achieved using one-way ANOVA, followed by the Tukey post hoc test using SPSS (version 22).
Results: Chronic implementation of combined training significantly downregulated final weight (P=0.033), protein levels of NLRP3, Caspase-1, and IL-1β (P=0.03, 0.001 and 0.019, respectively) in the cardiac tissue as well as modulation the homeostatic model assessment for insulin resistance (HOMA-IR: P=0.039) via attenuation of serum glucose and insulin levels (P=0.032 and 0.07) of the training group compared to the diabetic group. 
Conclusion: The modality of combined training (endurance+resistance) can reduce the risk factors associated with DCM in the myocardium of type 2 diabetic rats.

تازه های تحقیق

Kambiz Pourfarzad (Google Scholar) 
Simin Riahy (Google Scholar)

کلیدواژه‌ها
Diabetic cardiomyopathies؛ Interleukin؛ Cytokines؛ Caspase؛ Exercise
مراجع
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