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Gholami, Ahmad, Barzegar, Alireza, Ireji, Aida, Mohagheghzadeh, Abdolali, Ghasemi, Younes. (1405). The Role of Sulfur-Rich Phytochemical Coronas in the Synergistic Green Synthesis of Potent Silver Nanobiocides using Endemic Ferula Species. سامانه مدیریت نشریات علمی, 12(2), -. doi: 10.30476/tips.2026.111623.1359
Ahmad Gholami; Alireza Barzegar; Aida Ireji; Abdolali Mohagheghzadeh; Younes Ghasemi. "The Role of Sulfur-Rich Phytochemical Coronas in the Synergistic Green Synthesis of Potent Silver Nanobiocides using Endemic Ferula Species". سامانه مدیریت نشریات علمی, 12, 2, 1405, -. doi: 10.30476/tips.2026.111623.1359
Gholami, Ahmad, Barzegar, Alireza, Ireji, Aida, Mohagheghzadeh, Abdolali, Ghasemi, Younes. (1405). 'The Role of Sulfur-Rich Phytochemical Coronas in the Synergistic Green Synthesis of Potent Silver Nanobiocides using Endemic Ferula Species', سامانه مدیریت نشریات علمی, 12(2), pp. -. doi: 10.30476/tips.2026.111623.1359
Gholami, Ahmad, Barzegar, Alireza, Ireji, Aida, Mohagheghzadeh, Abdolali, Ghasemi, Younes. The Role of Sulfur-Rich Phytochemical Coronas in the Synergistic Green Synthesis of Potent Silver Nanobiocides using Endemic Ferula Species. سامانه مدیریت نشریات علمی, 1405; 12(2): -. doi: 10.30476/tips.2026.111623.1359

The Role of Sulfur-Rich Phytochemical Coronas in the Synergistic Green Synthesis of Potent Silver Nanobiocides using Endemic Ferula Species

Trends in Pharmaceutical Sciences and Technologies
دوره 12، شماره 2، شهریور 2026
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2026.111623.1359
نویسندگان
Ahmad Gholami* 1؛ Alireza Barzegar2؛ Aida Ireji3؛ Abdolali Mohagheghzadeh4؛ Younes Ghasemi2
1Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
The rising prevalence of multidrug-resistant (MDR) pathogens has heightened the need for sustainable, high-potency biocides. This work describes an aqueous root extract-based synergistic hybrid approach for green synthesis of silver nanoparticles (AgNPs) from two endemic Iranian species, Ferula assa-foetida and Ferula persica. Here, we established a precise morphological control framework using sodium citrate (NaC) as a co-reductant, in which increasing the citrate ratio effectively adjusted nanoparticle dimensions from 129 to 42 nm. UV-Vis, XRD, FESEM, and DLS were used to comprehensively characterize the formation of crystalline silver cores encapsulated within a robust sulfur-rich biomolecular corona. FTIR and EDS analysis confirmed a phytochemical-specific silver-sulfur (Ag-S) interface. The F. persica-mediated nanoparticles exhibited excellent colloidal stability, with zeta potential values ranging from -40 to -60 mV.
In antimicrobial assays, biogenic AgNPs showed significantly improved inhibitory profiles compared to chemically synthesized AgNPs. The Per/NaC 1/10 variant was found to be the most effective candidate with a remarkable Minimum Inhibitory Concentration (MIC) of 1 µg/mL against Staphylococcus aureus and 10 µg/mL against other bacterial strains. The nanoparticles exhibited broad-spectrum antibacterial activity; however, relative resistance to Candida albicans was observed, underscoring the influence of cell wall architecture on nano-bio interactions. The results highlight the importance of Ferula species as effective bio-templates for nanomanufacturing and provide a standardized route for developing next-generation biocompatible antimicrobial agents from endemic flora.
کلیدواژه‌ها
Green synthesis؛ Ferula persica؛ Ferula assa-foetida؛ Silver nanoparticles؛ Antimicrobial resistance؛ Bio-molecular corona
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تعداد مشاهده مقاله: 5


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