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Aalipour Hafshejani, Zahra, Yousefi Darani, Morteza, Aghebati, Mohammad, Shirzadi, Alireza. (1405). A Narrative Review on Targeting Neurokinin-1 Receptor (NK1R) System: A New Strategy for Breast Cancer Treatment. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/mejc.2026.109106.2353
Zahra Aalipour Hafshejani; Morteza Yousefi Darani; Mohammad Aghebati; Alireza Shirzadi. "A Narrative Review on Targeting Neurokinin-1 Receptor (NK1R) System: A New Strategy for Breast Cancer Treatment". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/mejc.2026.109106.2353
Aalipour Hafshejani, Zahra, Yousefi Darani, Morteza, Aghebati, Mohammad, Shirzadi, Alireza. (1405). 'A Narrative Review on Targeting Neurokinin-1 Receptor (NK1R) System: A New Strategy for Breast Cancer Treatment', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/mejc.2026.109106.2353
Aalipour Hafshejani, Zahra, Yousefi Darani, Morteza, Aghebati, Mohammad, Shirzadi, Alireza. A Narrative Review on Targeting Neurokinin-1 Receptor (NK1R) System: A New Strategy for Breast Cancer Treatment. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/mejc.2026.109106.2353

A Narrative Review on Targeting Neurokinin-1 Receptor (NK1R) System: A New Strategy for Breast Cancer Treatment

Middle East Journal of Cancer
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 11 دی 1405    اصل مقاله (723.37 K)
نوع مقاله: Review Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2026.109106.2353
نویسندگان
Zahra Aalipour Hafshejani1؛ Morteza Yousefi Darani* 2؛ Mohammad Aghebati2؛ Alireza Shirzadi3
1Department of Medical Laboratory Sciences, School of Paramedical Sciences, Zanjan University of Medical Sciences, Zanjan, Iran.
2Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3Department of Surgery, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
چکیده
Breast cancer is among the leading causes of cancer-related death worldwide, with its incidence steadily increasing. While multiple factors contribute to its development, understanding the interplay of molecular and cellular pathways is essential for effective therapeutic strategies. Among these, the tachykinin family—particularly the neurokinin-1 receptor (NK1R)—has emerged as a significant player in breast cancer progression. Substance P, a key agonist of NK1R, and the proliferative marker Ki-67, have both been implicated in tumor development. The purpose of this narrative review was to examine recent findings suggesting that NK1R antagonists not only exert antiproliferative and antitumor effects but may also mitigate chemotherapy-induced side effects, such as nausea. These observations clarify existing gaps related to the connection between NK1R, substance P, and Ki-67, and the level of confidence in the drug efficacy of breast cancer.
کلیدواژه‌ها
Breast neoplasms؛ Neurokinin-1 receptor (NK1R)؛ Substance P؛ Ki-67؛ Targeted therapy
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