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Habibi, Danial, Teymoori, Farshad, Haghighatdoost, Fahimeh, Tehrani Fateh, Sahand, Masjoudi, Sajedeh, Saeidian, Amir Hossein, Soleymani Taloubaghi, Alireza, Rafiei, Taha, Rahmati, Soheil, Rafiei, Mohammad, Farhadnejad, Hossein, Mirtavoos-Mahyari, Hanifeh, Hakonarson, Hakon, Azizi, Fereidoun, Hedayati, Mehdi, Daneshpour, Maryam Sadat, Mansourian, Marjan, Akbarzadeh, Mahdi. (1405). High Serum Monounsaturated Fatty Acids Levels May Increase Risk of Cardiovascular Disease: A Mendelian Randomization Study. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2026.107801.4239
Danial Habibi; Farshad Teymoori; Fahimeh Haghighatdoost; Sahand Tehrani Fateh; Sajedeh Masjoudi; Amir Hossein Saeidian; Alireza Soleymani Taloubaghi; Taha Rafiei; Soheil Rahmati; Mohammad Rafiei; Hossein Farhadnejad; Hanifeh Mirtavoos-Mahyari; Hakon Hakonarson; Fereidoun Azizi; Mehdi Hedayati; Maryam Sadat Daneshpour; Marjan Mansourian; Mahdi Akbarzadeh. "High Serum Monounsaturated Fatty Acids Levels May Increase Risk of Cardiovascular Disease: A Mendelian Randomization Study". سامانه مدیریت نشریات علمی, , , 1405, -. doi: 10.30476/ijms.2026.107801.4239
Habibi, Danial, Teymoori, Farshad, Haghighatdoost, Fahimeh, Tehrani Fateh, Sahand, Masjoudi, Sajedeh, Saeidian, Amir Hossein, Soleymani Taloubaghi, Alireza, Rafiei, Taha, Rahmati, Soheil, Rafiei, Mohammad, Farhadnejad, Hossein, Mirtavoos-Mahyari, Hanifeh, Hakonarson, Hakon, Azizi, Fereidoun, Hedayati, Mehdi, Daneshpour, Maryam Sadat, Mansourian, Marjan, Akbarzadeh, Mahdi. (1405). 'High Serum Monounsaturated Fatty Acids Levels May Increase Risk of Cardiovascular Disease: A Mendelian Randomization Study', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2026.107801.4239
Habibi, Danial, Teymoori, Farshad, Haghighatdoost, Fahimeh, Tehrani Fateh, Sahand, Masjoudi, Sajedeh, Saeidian, Amir Hossein, Soleymani Taloubaghi, Alireza, Rafiei, Taha, Rahmati, Soheil, Rafiei, Mohammad, Farhadnejad, Hossein, Mirtavoos-Mahyari, Hanifeh, Hakonarson, Hakon, Azizi, Fereidoun, Hedayati, Mehdi, Daneshpour, Maryam Sadat, Mansourian, Marjan, Akbarzadeh, Mahdi. High Serum Monounsaturated Fatty Acids Levels May Increase Risk of Cardiovascular Disease: A Mendelian Randomization Study. سامانه مدیریت نشریات علمی, 1405; (): -. doi: 10.30476/ijms.2026.107801.4239

High Serum Monounsaturated Fatty Acids Levels May Increase Risk of Cardiovascular Disease: A Mendelian Randomization Study

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 27 تیر 1405    اصل مقاله (2.01 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2026.107801.4239
نویسندگان
Danial Habibi1؛ Farshad Teymoori2، 3؛ Fahimeh Haghighatdoost4؛ Sahand Tehrani Fateh5؛ Sajedeh Masjoudi6؛ Amir Hossein Saeidian7؛ Alireza Soleymani Taloubaghi8؛ Taha Rafiei9؛ Soheil Rahmati10؛ Mohammad Rafiei11؛ Hossein Farhadnejad12؛ Hanifeh Mirtavoos-Mahyari13؛ Hakon Hakonarson7، 14، 15؛ Fereidoun Azizi16؛ Mehdi Hedayati6؛ Maryam Sadat Daneshpour6؛ Marjan Mansourian17؛ Mahdi Akbarzadeh* 6
1Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
2Nutritional Sciences Research Center, Iran University of Medical Sciences, Tehran, Iran
3Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
4Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
5School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7Center for Applied Genomics, The Children’s Hospital of Philadelphia, Abramson Research Building, Suite 1016I, 3615 Civic Center Boulevard, Philadelphia, PA, 19104-4318, USA
8Data Science and AI Applications, Graduate School of Engineering Science and Technology, National Yunlin University of Science and Technology, Douliu, Taiwan
9School of Medicine, Arak University of Medical Sciences, Arak, Iran
10Student Research Committee, Ramsar Campus, Mazandaran University of Medical Sciences, Ramsar, Iran
11Department of Biostatistics, School of Medicine, Arak University of Medical Sciences, Arak, Iran
12Nutrition and Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
13Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
14Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
15Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
16Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciaences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
17Epidemiology and Biostatistics Department, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Background: Monounsaturated fatty acids (MUFAs) are dietary and circulating fats that may influence cardiovascular health. However, their causal role in cardiovascular diseases (CVDs) remains unclear due to conflicting observational evidence. This study aimed to determine the causal relationship of high serum MUFAs with the risk of various CVDs using the Mendelian randomization (MR) design. 
Methods: The summary statistics dataset related to serum MUFAs was used from the published genome-wide association study (GWAS) of European descent in UK Biobank participants (n=114,999). Genetic variants underlying angina, atherosclerotic, ischemic heart disease (IHD), myocardial infarction (MI), and hypertension events were ascertained using a GWAS dataset of 461,880 (case=14,828, control=447,052), 463,010 (case=12,171, control=450,839), 361,194 (case=20,857, control=340,337), 462,933 (case=10,616, control=452,317), and 461,880 (case=124,227, control=337,653) European descent participants from the UK Biobank, respectively. We investigated potential association relationships between MUFAs and these outcomes using generalized summary Mendelian randomization (GSMR) and two-sample Mendelian randomization (TSMR). TSMR was employed to validate associations identified by GSMR. The results were reported as odds ratios (ORs) with 95% confidence intervals (CIs). 
Results: GSMR results showed that MUFAs were associated with angina (OR=1.007, 95%CI:1.005–1.009; P<0.001), atherosclerotic (OR=1.006, 95%CI:1.004–1.008; P<0.001), IHD (OR=1.006, 95%CI:1.003–1.009; P<0.001), MI (OR=1.003, 95%CI:1.001–1.005; P<0.001), and hypertension (OR=1.003, 95%CI:0.998–1.008; P<0.001). Besides, TSMR results indicated that MUFAs were associated with angina (OR=1.012, 95%CI:1.010–1.015), atherosclerotic (OR=1.009, 95%CI:1.006–1.011; P<0.001), IHD (OR=1.015, 95%CI:1.010–1.019; P<0.001), MI (OR=1.007, 95%CI:1.004–1.009; P<0.001), and hypertension (OR=1.021, 95%CI:1.011–1.031; P<0.001). These findings remained consistent when utilizing different MR methods and sensitivity analyses.
Conclusion: The current MR study indicated that higher levels of MUFAs might be associated with an increased risk of CVD events.

تازه های تحقیق

Danial Habibi (Google Scholar)
Mahdi Akbarzadeh (Google Scholar) 

کلیدواژه‌ها
Monounsaturated fatty acids؛ Cardiovascular diseases؛ Mendelian randomization analysis؛ Angina pectoris؛ Hypertension
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